Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

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Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen is …
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P356DOI10.1016/S1473-3099(16)30385-1
P698PubMed publication ID28159534

P50authorLisa NgQ22279398
Ali ZaidQ47098735
Lara HerreroQ47504472
Suresh MahalingamQ55190793
Alain KohlQ60956090
Jonathan J MinerQ66738963
Adam TaylorQ84145121
Deborah J. LenschowQ85543822
Felicity J BurtQ88887992
Penny A RuddQ115653680
Andres MeritsQ24546306
P2093author name stringWeiqiang Chen
Esther Schnettler
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A226V strains of Chikungunya virus, Réunion Island, 2010.Q42953154
First cases of autochthonous dengue fever and chikungunya fever in France: from bad dream to reality!Q43001209
Betulin-derived compounds as inhibitors of alphavirus replicationQ43259109
Subunit vaccine formulations based on recombinant envelope proteins of Chikungunya virus elicit balanced Th1/Th2 response and virus-neutralizing antibodies in miceQ43658672
A destructive arthropathy following Chikungunya virus arthritis--a possible associationQ44164039
Development of an attenuated strain of chikungunya virus for use in vaccine productionQ44523303
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replicationQ44849183
Morbidity and impaired quality of life 30 months after chikungunya infection: comparative cohort of infected and uninfected French military policemen in Reunion IslandQ44849348
Interleukin 6, RANKL, and osteoprotegerin expression by chikungunya virus-infected human osteoblastsQ44849436
Emergence and potential for spread of Chikungunya virus in BrazilQ24288877
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophagesQ24288996
Chikungunya, an epidemic arbovirosisQ24291001
Chikungunya virus infectionQ24497757
Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationshipsQ24570057
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signalingQ24594497
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shockQ24598171
Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoffQ24606603
Four cases of acute flaccid paralysis associated with chikungunya virus infectionQ24616926
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase IIQ24619991
Chikungunya infection in travelersQ24628887
A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infectionQ24631774
Chikungunya: epidemiologyQ24701719
New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference PathwaysQ24701745
Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Q24701750
Early Events in Chikungunya Virus Infection-From Virus Cell Binding to Membrane FusionQ24701760
Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infectionQ24701763
Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityQ24701782
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritisQ24701793
Alphavirus RNA synthesis and non-structural protein functionsQ24701805
Viral infections in travellers from tropical AfricaQ27477517
Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virusQ27487330
The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding PocketQ27488798
Chikungunya Virus, Cameroon, 2006Q27489543
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severityQ28476579
NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 proteinQ28479203
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from diseaseQ28533408
Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor libraryQ28534763
A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritisQ34703785
Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolatesQ34926408
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunityQ34927480
Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapesQ34977748
Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forcesQ34979371
Prophylaxis and therapy for Chikungunya virus infectionQ34990306
Discovery of mosquito saliva microRNAs during CHIKV infectionQ35000969
Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody responseQ35023852
Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolutionQ35140421
BST2/tetherin inhibition of alphavirus exitQ35544442
A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus InfectionQ35641902
A Rodent Model of Chikungunya Virus Infection in RAG1 -/- Mice, with Features of Persistence, for Vaccine Safety EvaluationQ35675871
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya VirusQ35850197
Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritisQ36114846
A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine designQ36171996
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and EgressQ36318652
Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasmQ36332866
Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine developmentQ36397446
A chimeric vesiculo/alphavirus is an effective alphavirus vaccineQ36506753
Chikungunya and the eye: a reviewQ36707161
Nonstructural protein 2 (nsP2) of Chikungunya virus (CHIKV) enhances protective immunity mediated by a CHIKV envelope protein expressing DNA VaccineQ36837548
Molecular Characterization of Chikungunya Virus, Philippines, 2011-2013Q36884925
A polarized cell model for Chikungunya virus infection: entry and egress of virus occurs at the apical domain of polarized cellsQ28539957
Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infectionQ28539964
Infection with chikungunya virus in Italy: an outbreak in a temperate regionQ29346487
An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical featuresQ29620004
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replicationQ30009234
The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BPQ30009448
Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infectionQ30009987
SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replicationQ30010201
Chikungunya in the AmericasQ30080031
US Military contributions to the global response to pandemic chikungunyaQ30224145
A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primatesQ30398956
Production of virus-derived ping-pong-dependent piRNA-like small RNAs in the mosquito somaQ31045021
Tracking the re-emergence of epidemic chikungunya virus in IndonesiaQ31146393
In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combinationQ33195882
Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patientsQ33375141
Mother-to-child transmission of Chikungunya virus infectionQ33376362
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodiesQ33517926
Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.Q33684369
Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cellsQ33744635
Epidemiology, clinical manifestations, and diagnosis of Chikungunya fever: lessons learned from the re-emerging epidemicQ33796693
BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1)Q33861091
Neurocognitive outcome of children exposed to perinatal mother-to-child Chikungunya virus infection: the CHIMERE cohort study on Reunion IslandQ33916134
Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replicationQ33945559
Co-circulation of Dengue and Chikungunya Viruses, Al Hudaydah, Yemen, 2012.Q33951110
Guillain-Barré syndrome complicating a Chikungunya virus infectionQ34008392
Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006.Q34013185
Acute Arboviral Infections in Guinea, West Africa, 2006Q34024894
Species-specific impact of the autophagy machinery on Chikungunya virus infectionQ34036496
Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imagingQ34099818
Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergenceQ34102716
Arthritogenic alphaviruses--an overviewQ34273343
A pathogenic role for CD4+ T cells during Chikungunya virus infection in miceQ34315384
Comparative pathogenesis of epidemic and enzootic Chikungunya viruses in a pregnant Rhesus macaque modelQ34341822
Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune responseQ34378105
Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 miceQ34394530
Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse modelQ37065242
Chikungunya fever outbreak, Bhutan, 2012Q37261986
Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritisQ37331952
Antiviral treatment of chikungunya virus infectionQ37411581
Next generation sequencing reveals regulation of distinct Aedes microRNAs during chikungunya virus developmentQ37464859
Atypical manifestations of chikungunya infectionQ37588903
A novel poxvirus-based vaccine, MVA-CHIKV, is highly immunogenic and protects mice against chikungunya infection.Q37643733
Arbovirus vaccines; opportunities for the baculovirus-insect cell expression systemQ37904374
Beyond RNAi: antiviral defense strategies in Drosophila and mosquitoQ38028736
Chikungunya virus: an update on antiviral development and challengesQ38107673
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.Q38415017
Chikungunya: Evolutionary history and recent epidemic spreadQ38483795
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virusQ38895828
The occurrence of Chikungunya virus in Uganda. I. Isolation from mosquitoesQ38899220
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviralQ38982527
Seroprevalence of dengue, chikungunya and Sindbis virus infections in German aid workersQ38983563
Use of human monoclonal antibodies to treat Chikungunya virus infectionQ39012242
Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.Q39037522
Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against chikungunya virusQ39299364
An imported case of Chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countriesQ39358394
Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trialQ39382188
Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral componentQ39410121
Epidemic resurgence of Chikungunya virus in democratic Republic of the Congo: identification of a new central African strainQ39693095
Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults.Q39757948
Chikungunya outbreak in Montpellier, France, September to October 2014.Q40156908
Chikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein responseQ40182946
Chikungunya outbreak in the Caribbean region, December 2013 to March 2014, and the significance for EuropeQ40210825
Emergence of chikungunya fever on the French side of Saint Martin island, October to December 2013.Q40210836
Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine/chemokine levels during acute Chikungunya virus infectionQ40217985
Chikungunya virus-like particles are more immunogenic in a lethal AG129 mouse model compared to glycoprotein E1 or E2 subunitsQ40232449
Cytokine levels in patients with chikungunya virus infectionQ40243475
A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virusQ40245153
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieriQ40275796
Cluster of chikungunya virus infection in travelers returning from Senegal, 2006.Q40382482
An outbreak of yellow fever with concurrent chikungunya virus transmission in South Kordofan, Sudan, 2005.Q40418405
Seroprevalence of Chikungunya virus (CHIKV) infection on Lamu Island, Kenya, October 2004.Q40427692
Circulation of Chikungunya virus in Gabon, 2006-2007.Q40429258
Chikungunya fever as a risk factor for endemic Burkitt's lymphoma in MalawiQ40607929
Seroprevalence of five arboviruses in Zebu cattle in the Central African RepublicQ40675363
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trialQ42199381
Chikungunya virus capsid protein contains nuclear import and export signalsQ42273688
The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signalingQ42283124
Chikungunya disease outbreak, Reunion Island.Q42616934
P433issue4
P921main subjectchikungunyaQ243257
pathogenesisQ372016
Chikungunya virusQ15794049
emerging pathogenQ108429945
P304page(s)e107-e117
P577publication date2017-01-31
P1433published inLancet Infectious DiseasesQ15724248
P1476titleChikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
P478volume17

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