| scholarly article | Q13442814 |
| P2093 | author name string | J. R. Ortaldo | |
| S. Gupta | |||
| Y. Q. Chen | |||
| C. M. Bacon | |||
| D. Kaplan | |||
| D. S. Finbloom | |||
| J. A. Johnston | |||
| J. D. Giri | |||
| K. Shibuya | |||
| R. C. Rees | |||
| P2860 | cites work | Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12 | Q24306559 |
| Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor | Q24313035 | ||
| Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes | Q24313200 | ||
| Identification and purification of human Stat proteins activated in response to interleukin-2 | Q24314547 | ||
| Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4 | Q24323130 | ||
| Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor | Q24323232 | ||
| Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15 | Q24595192 | ||
| Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins | Q27860890 | ||
| A protein tyrosine kinase in the interferon alpha/beta signaling pathway | Q28116574 | ||
| Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors | Q28235378 | ||
| Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID | Q28241595 | ||
| Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells | Q28244421 | ||
| An interleukin-4-induced transcription factor: IL-4 Stat | Q28248059 | ||
| Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes | Q28295404 | ||
| Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 | Q28637521 | ||
| Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein | Q28646517 | ||
| Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation | Q30450222 | ||
| Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission | Q34229092 | ||
| Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. | Q34329668 | ||
| Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors | Q35599721 | ||
| Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. | Q36277342 | ||
| Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor | Q36363861 | ||
| Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases | Q36745947 | ||
| Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. | Q37627335 | ||
| Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements | Q37644830 | ||
| Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. | Q38301684 | ||
| The mammary factor MPBF is a prolactin‐induced transcriptional regulator which binds to STAT factor recognition sites | Q38305266 | ||
| Jaks and Stats in signaling by the cytokine receptor superfamily | Q40506662 | ||
| Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription | Q40793223 | ||
| Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways | Q40874268 | ||
| Gene transfer of the interleukin (IL)-2 receptor beta chain into an IL-7-dependent pre-B cell line permits IL-2-driven proliferation: tyrosine phosphorylation of Shc is induced by IL-2 but not IL-7. | Q41443318 | ||
| Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors | Q42692057 | ||
| Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans | Q45874932 | ||
| The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. | Q50335906 | ||
| Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor | Q68007089 | ||
| Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes | Q71665305 | ||
| Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation | Q72135919 | ||
| Tyrosine phosphorylation of DNA binding proteins by multiple cytokines | Q72936922 | ||
| P433 | issue | 19 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | interleukins | Q194908 |
| phosphorylation | Q242736 | ||
| P304 | page(s) | 8705–8709 | |
| P577 | publication date | 1995-09-12 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 | |
| P478 | volume | 92 |
| Q34486338 | A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function |
| Q26823326 | A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis |
| Q40532205 | A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. |
| Q24338958 | A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons |
| Q36477217 | A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation |
| Q34714685 | A specific immune transcriptomic profile discriminates chronic kidney disease patients in predialysis from hemodialyzed patients |
| Q28543980 | A systems model of phosphorylation for inflammatory signaling events |
| Q36768723 | Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation |
| Q42827073 | Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells |
| Q40939460 | Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation |
| Q40020509 | Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons |
| Q78377103 | Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma |
| Q37130282 | Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels |
| Q22254246 | Altered natural killer cell differentiation in CD34+ progenitors from chronic myeloid leukemia patients |
| Q28212401 | Alternate signalling pathways from the interleukin-2 receptor |
| Q35681527 | Antibodies in the prevention of renal allograft rejection |
| Q37347718 | Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients |
| Q40970070 | Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells |
| Q45113910 | Biology of the interleukin-2 receptor |
| Q40691071 | Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils |
| Q34605017 | Cell death mechanisms induced by cytotoxic lymphocytes |
| Q36741326 | Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes |
| Q41058422 | Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex |
| Q35082617 | Combined stimulation of IL-2 and 4-1BB receptors augments the antitumor activity of E7 DNA vaccines by increasing Ag-specific CTL responses |
| Q33961743 | Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains |
| Q35085222 | Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells |
| Q42741704 | Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. |
| Q27648832 | Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation |
| Q41865091 | Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models |
| Q41667279 | Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2. |
| Q36562956 | Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. |
| Q24682863 | Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV) |
| Q35227733 | Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro |
| Q41196737 | Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line |
| Q33731594 | Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity |
| Q47113855 | Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling |
| Q99594209 | Dynamic Roles for IL-2-STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations |
| Q40645100 | Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. |
| Q45094789 | Endogenous IL-15 sustains recruitment of IL-2Rbeta and common gamma and IL-2-mediated chemokine production in normal and inflamed human gingival fibroblasts |
| Q49376152 | Epigenetic Maintenance of Acquired Gene Expression Programs during Memory CD8 T Cell Homeostasis. |
| Q50207787 | Erythropoietin Rescues Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via the EPO-R/JAK2/STAT5/PI3K/Akt/GSK-3β Pathway |
| Q35906417 | Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation |
| Q34172690 | Essential role of interleukin-15 receptor in normal anxiety behavior |
| Q28585244 | Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier |
| Q41176633 | Formation of STAT5-containing DNA binding complexes in response to colony-stimulating factor-1 and platelet-derived growth factor |
| Q38019210 | Functions of IL-15 in anti-viral immunity: multiplicity and variety |
| Q42670498 | GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines |
| Q33928557 | Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems |
| Q35859357 | Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma |
| Q28115484 | Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation |
| Q38348283 | Human CD94 Gene Expression: Dual Promoters Differing in Responsiveness to IL-2 or IL-15 |
| Q35920922 | Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site |
| Q40951638 | Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells |
| Q33788829 | IL-15: a central regulator of celiac disease immunopathology |
| Q40976868 | IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels |
| Q28214975 | IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells |
| Q22254639 | IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21 |
| Q44394226 | IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells |
| Q42451040 | IL-2 and IL-15 manifest opposing effects on activation of nuclear factor of activated T cells |
| Q39022984 | IL-2 enhances cervical cancer cells proliferation and JAK3/STAT5 phosphorylation at low doses, while at high doses IL-2 has opposite effects. |
| Q35661491 | IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells. |
| Q58040379 | IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines |
| Q24307467 | IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response |
| Q45288811 | IL-7 downregulates IL-7Rα expression in human CD8 T cells by two independent mechanisms |
| Q50292586 | IL15 binds IL2RB:JAK1 and IL2RG:JAK3 |
| Q50292590 | IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 |
| Q50292592 | IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 |
| Q50292587 | IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 |
| Q57599600 | IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells |
| Q28252347 | Identification of an interleukin-15alpha receptor-binding site on human interleukin-15 |
| Q43828214 | Immune reconstitution after autologous peripheral blood progenitor cell transplantation: effect of interleukin-15 on T-cell survival and effector functions |
| Q41103002 | Immunodeficiencies caused by genetic defects in protein kinases |
| Q73297943 | Impaired NK cell differentiation of blood-derived CD34+ progenitors from patients with myeloid metaplasia with myelofibrosis |
| Q45861858 | Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance. |
| Q36366827 | In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction |
| Q54310181 | Increased serum levels of interleukin-15 correlate with negative prognostic factors in extranodal NK/T cell lymphoma. |
| Q38346668 | Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells: differential association of Sp1-DNA complexes with Stats |
| Q42857041 | Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal |
| Q37417482 | Integration of cytokine and heterologous receptor signaling pathways |
| Q77354075 | Interleukin (IL)-15 induces survival and proliferation of the growth factor-dependent acute myeloid leukemia M-07e through the IL-2 receptor beta/gamma |
| Q39479140 | Interleukin-15 affects differentiation and apoptosis in adipocytes: implications in obesity. |
| Q38264072 | Interleukin-15 in the treatment of cancer |
| Q71118255 | Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells |
| Q41048144 | Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues |
| Q38359029 | Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. |
| Q41722182 | Interleukin-2, interleukin-15, and their receptors |
| Q40270054 | Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells |
| Q33668794 | Interleukin-7: physiological roles and mechanisms of action |
| Q30409845 | Intravenous injection of a foamy virus vector to correct canine SCID-X1. |
| Q41109029 | Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. |
| Q82917953 | Jak3 contributes to the activation of ALK and Stat3 in ALK(+) anaplastic large cell lymphoma |
| Q28637960 | Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation |
| Q42705157 | Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis |
| Q42034976 | Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen |
| Q28750048 | Lymphoma and myeloma cell resistance to cytotoxic agents and ionizing radiations is not affected by exposure to anti-IL-6 antibody |
| Q81425145 | Massive interleukin-12-induced interferon-gamma production by interleukin-15-stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor |
| Q40649521 | Mast Cells Express Novel Functional IL-15 Receptor α Isoforms |
| Q89994527 | Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations |
| Q38204960 | Molecular pathways: interleukin-15 signaling in health and in cancer |
| Q48596563 | Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity |
| Q40023023 | Mutational analysis of acute-phase response factor/Stat3 activation and dimerization |
| Q41976595 | NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia |
| Q35828667 | Nonredundant roles for Stat5a/b in directly regulating Foxp3 |
| Q33623266 | Novel human interleukin-15 agonists |
| Q37372247 | Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes. |
| Q37873399 | Opportunistic invasive fungal pathogen Macrophomina phaseolina prognosis from immunocompromised humans to potential mitogenic RBL with an exceptional and novel antitumor and cytotoxic effect. |
| Q50532765 | Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice. |
| Q38934681 | Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells |
| Q73925270 | Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F |
| Q26747008 | Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer |
| Q37354449 | Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity |
| Q57371171 | Possible mechanism for the alpha subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction |
| Q50292572 | Recruited STAT5 is phosphorylated |
| Q34533098 | Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation |
| Q28085758 | Role of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoire |
| Q28236871 | STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction |
| Q42521886 | STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells |
| Q91692831 | Sepsis: Inflammation Is a Necessary Evil |
| Q47998022 | Severe combined immune deficiencies due to defects of the common gamma chain-JAK3 signaling pathway |
| Q50927988 | Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes. |
| Q41261282 | Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast. |
| Q52717934 | Signaling and Function of Interleukin-2 in T Lymphocytes. |
| Q38425096 | Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics |
| Q28507187 | Stat5 expression is critical for mast cell development and survival |
| Q28140287 | Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation |
| Q34253065 | Stat5a/b are essential for normal lymphoid development and differentiation |
| Q36750028 | Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin |
| Q34567937 | T lymphocyte activation--an inside overview. |
| Q36259774 | TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent |
| Q50737780 | TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. |
| Q54626776 | TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. |
| Q51766789 | The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
| Q34102456 | The IL-15R alpha chain signals through association with Syk in human B cells |
| Q37190531 | The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling |
| Q40995235 | The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain |
| Q35129712 | The role of CD95 in the regulation of peripheral T-cell apoptosis |
| Q36824184 | The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes |
| Q28088784 | The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy |
| Q77485579 | The use of antibodies against the IL-2 receptor in transplantation |
| Q41085823 | Transcriptional inhibition by Stat5. Differential activities at growth-related versus differentiation-specific promoters |
| Q61649466 | Transcriptional network profile on synovial fluid T cells in psoriatic arthritis |
| Q33889476 | Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes |
| Q35750908 | Vaccine-delivered HIV envelope inhibits CD4(+) T-cell activation, a mechanism for poor HIV vaccine responses |
| Q28483641 | n-Butylidenephthalide (BP) maintains stem cell pluripotency by activating Jak2/Stat3 pathway and increases the efficiency of iPS cells generation |
| Q50292595 | p-Y-STAT3 binds p-STAT5 |
| Q28343389 | p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes |
Search more.