Animal models of brain maldevelopment induced by cycad plant genotoxins

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Animal models of brain maldevelopment induced by cycad plant genotoxins is …
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scholarly articleQ13442814

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P356DOI10.1002/BDRC.21052
P3181OpenCitations bibliographic resource ID1507471
P932PMC publication ID4183057
P698PubMed publication ID24339036
P5875ResearchGate publication ID259336651

P2093author name stringHolly Moore
Peter S Spencer
Glen E Kisby
P2860cites workRethinking schizophreniaQ22251086
Short exposure to methylazoxymethanol causes a long-term inhibition of axonal outgrowth from cultured embryonic rat hippocampal neuronsQ23778323
The neurodevelopmental hypothesis of schizophrenia, revisitedQ24658343
Diminished experience-dependent neuroanatomical plasticity: evidence for an improved biomarker of subtle neurotoxic damage to the developing rat brainQ24815614
Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?Q26824755
The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked mannerQ27335106
Genotoxicants target distinct molecular networks in neonatal neuronsQ28392440
Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortexQ28580588
Neurogenesis in the adult is involved in the formation of trace memoriesQ29622890
Models of neurodevelopmental abnormalities in schizophreniaQ30457462
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophreniaQ30465716
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophreniaQ30478274
DNA repair modulates the vulnerability of the developing brain to alkylating agentsQ30488029
Damage and repair of nerve cell DNA in toxic stressQ30759422
Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).Q30858523
Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific regionQ33563145
Central nervous system neuronal migrationQ33593457
The molecular pathology of schizophrenia--focus on histone and DNA modificationsQ34236086
Patterns of Neurologic Diseases on GuamQ67215737
A survey of acute toxicity of cycads and mortality rate from cancer in the Miyako Islands, OkinawaQ68622841
Decomposition of methylazoxymethanol, the aglycone of cycasin, in D 2 OQ69170508
Hepatic and spinal lesions in goats chronically intoxicated with cycasinQ69759538
FOOD PRACTICES IN ALS FOCI IN JAPAN, THE MARIANAS, AND NEW GUINEAQ77097941
STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN. ISOLATION, BIOLOGICAL, AND CHEMICAL PROPERTIESQ78544325
Seizure Disorders in a Guamanian VillageQ78982983
Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage (Version 6)Q80841833
Altered spontaneous synaptic inhibition in an animal model of cerebral heterotopiasQ83331614
Animal models of drug-resistant epilepsyQ84933550
Chemical toxins that cause seizuresQ85240690
Azoxyglycoside contents in seeds of several cycad species and various parts of Japanese cycad.Q104388252
The magical and medicinal usage of Stangeria eriopus in South AfricaQ34326229
Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanolQ34582417
Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in uteroQ34604780
A cohort study of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam and RotaQ34692379
Long-lasting and transgenerational effects of an environmental enrichment on memory formationQ34758103
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteinsQ36570190
The MAM rodent model of schizophreniaQ36849520
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memoryQ37069063
Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumorsQ37476708
Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in ratsQ37831162
Does α-amino-β-methylaminopropionic acid (BMAA) play a role in neurodegeneration?Q37948045
Are developmental dysplastic lesions epileptogenic?Q38011832
Neuroanatomical and functional alterations resulting from early postnatal cerebellar insults in rodentsQ41290257
Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanolQ41336676
Microencephalic rats as a model for cognitive disordersQ41933631
Improved learning in microencephalic ratsQ41936979
Quantitative changes with age in the DNA content of methylazoxymethanol-induced microencephalic rat brainQ41938302
Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype.Q42110799
Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitroQ42147299
Similarities between the biochemical actions of cycasin and dimethylnitrosamineQ42172396
Western Pacific ALS-PDC: a prototypical neurodegenerative disorder linked to DNA damage and aberrant proteogenesis?Q42272424
O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesisQ43116085
Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flourQ44048562
Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbensQ44938375
Content of the neurotoxins cycasin (methylazoxymethanol -D-glucoside) and BNLAA ( -N-methylamino-L-alanine) in cycad flour prepared by Guam ChamorrosQ44940139
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.Q45983039
Molecular networks perturbed in a developmental animal model of brain injuryQ46443482
Proliferating progenitor cells: a required cellular element for induction of ischemic tolerance in the brainQ46718848
Cycad use and motor neurone disease in Kii peninsula of JapanQ47389914
The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia?Q47641740
A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating.Q48087950
Transport of cycasin by the intestinal Na+/glucose cotransporterQ48089519
Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam.Q48161371
Prenatal methylazoxymethanol treatment in rats produces brain abnormalities with morphological similarities to human developmental brain dysgenesesQ48284950
Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat.Q48421003
Transplacentally induced neuronal migration disorders: an animal model for the study of the epilepsiesQ48503694
Na+-dependent and phlorizin-inhibitable transport of glucose and cycasin in brain endothelial cells.Q48547011
Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.Q48942924
Structural abnormalities revealed by magnetic resonance imaging in rats prenatally exposed to methylazoxymethanol acetate parallel cerebral pathology in schizophreniaQ50442482
Functional effects of methylazoxymethanol-induced cerebellar hypoplasia in rats.Q50996935
Motor neuron disease on Guam: geographic and familial occurrence, 1956-85.Q50999191
Studies on Methylazoxymethanol: Methylation of Nucleic Acids in the Fetal Rat BrainQ51159002
Postnatal methylazoxymethanol: sensitive periods and regional selectivity of effects.Q52213285
Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primatesQ53576592
The pathogenesis of amyotrophic lateral sclerosis.Q54253622
The experimental pathology of cycad toxicity with special reference to oncogenic effects.Q54436419
Toxicity of cycadsQ56093624
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectembryologyQ131683
P304page(s)247-55
P577publication date2013-12-01
P1433published inBirth Defects Research Part C: Embryo Today ReviewsQ15757886
P1476titleAnimal models of brain maldevelopment induced by cycad plant genotoxins
P478volume99

Reverse relations

cites work (P2860)
Q40957607Accrued somatic mutations (nucleic acid changes) trigger ALS: 2005-2015 update
Q67496222Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia.
Q67496287Adolescent social isolation affects parvalbumin expression in the medial prefrontal cortex in the MAM-E17 model of schizophrenia.
Q50997278Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model.
Q44877586The neurodevelopmental toxicity of heavy metals: A fish perspective.
Q37025492Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.

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