Design of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis

scientific article (publication date: 15 March 2011)

Design of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...617881A
P356DOI10.1371/JOURNAL.PONE.0017881
P932PMC publication ID3058040
P698PubMed publication ID21423632
P5875ResearchGate publication ID50597144

P50authorBalik DzhambazovQ43169725
Tsvetelina BatsalovaQ59696138
P2093author name stringRikard Holmdahl
Anna Linusson
C David Andersson
Jan Kihlberg
Ida E Andersson
P2860cites workPeptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structuresQ27622749
Structural and functional consequences of altering a peptide MHC anchor residueQ27629883
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X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen IIQ27746792
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Comparison of consensus scoring strategies for evaluating computational models of protein-ligand complexesQ28292827
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisQ28306666
A critical assessment of docking programs and scoring functionsQ29616761
Statistical molecular design of peptoid librariesQ30643663
Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritisQ30878890
Improving structure-based virtual screening by multivariate analysis of scoring dataQ30885875
Detailed analysis of scoring functions for virtual screeningQ30985789
Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritisQ31089923
MUC1-derived glycopeptide libraries with improved MHC anchors are strong antigens and prime mouse T cells for proliferative responses to lysates of human breast cancer tissueQ31144055
Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coliQ31147826
Evaluation and application of multiple scoring functions for a virtual screening experimentQ33209809
Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritisQ33281660
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Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice.Q35605653
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsivenessQ36009049
Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlatesQ36345534
Consensus scoring for protein-ligand interactionsQ36458866
Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.Q36498837
Modeling the structure of bound peptide ligands to major histocompatibility complexQ36519420
Deciphering common failures in molecular docking of ligand-protein complexes.Q38305525
Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151.Q40450058
Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis.Q40480825
Radically altered T cell receptor signaling in glycopeptide-specific T cell hybridoma induced by antigen with minimal differences in the glycan groupQ40763215
Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility moleculesQ40945287
Characterization of a peptide analog of a determinant of type II collagen that suppresses collagen-induced arthritis.Q41005128
Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen-induced arthritisQ41173522
Modification of peptide interaction with MHC creates TCR partial agonistsQ42045156
T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk.Q42086872
Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263-275) epitope: an MHC anchor variant peptide for immune modulationQ42963596
Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins.Q43058987
Glycopeptide specificity of helper T cells obtained in mouse models for rheumatoid arthritisQ44237847
Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides.Q45181052
Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55.Q45213685
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonistsQ46121537
Ligand recognition by alpha beta T cell receptorsQ46222293
Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II moleculesQ46902180
Probing molecular interactions within class II MHC Aq/glycopeptide/T-cell receptor complexes associated with collagen-induced arthritisQ46943892
Structural mining: self-consistent design on flexible protein-peptide docking and transferable binding affinity potentialQ47239403
A detailed comparison of current docking and scoring methods on systems of pharmaceutical relevanceQ47307422
Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis.Q48028246
Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator.Q50893484
Comparative performance assessment of the conformational model generators omega and catalyst: a large-scale survey on the retrieval of protein-bound ligand conformations.Q51936967
Predicting binding affinities of protein ligands from three-dimensional models: application to peptide binding to class I major histocompatibility proteins.Q52135209
Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.Q53678858
The Collinearity Problem in Linear Regression. The Partial Least Squares (PLS) Approach to Generalized InversesQ56454402
PLS-regression: a basic tool of chemometricsQ56454404
Principal component analysisQ56763826
Analysis of key parameters for molecular dynamics of pMHC moleculesQ58616537
Immunisation against heterologous type II collagen induces arthritis in miceQ59053172
A New Concept for Multidimensional Selection of Ligand Conformations (MultiSelect) and Multidimensional Scoring (MultiScore) of Protein−Ligand Binding AffinitiesQ62648697
Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selectionQ67539006
A synthetic peptide analogue of a determinant of type II collagen prevents the onset of collagen-induced arthritisQ70682099
Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritisQ72049171
Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401Q72332685
The structural basis of MHC control of collagen-induced arthritis; binding of the immunodominant type II collagen 256-270 glycopeptide to H-2Aq and H-2Ap moleculesQ74375742
High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signalingQ77769114
Major histocompatibility complex class II binding characteristics of peptoid-peptide hybridsQ77892128
Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic miceQ78667423
Modeling ligand-receptor interaction for some MHC class II HLA-DR4 peptide mimetic inhibitors using several molecular docking and 3D QSAR techniquesQ81253747
Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritisQ83953115
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCII259-273Q27131830
Gly-Ile-Ala-Gly-Phe(4-F)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131831
Gly-Ile-Ala-Gly-Tyr-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131832
Gly-Ile-Ala-Gly-Ala(thiazol-4-yl)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131834
Gly-Hle-Ala-Gly-Phe(4-F)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131835
Gly-Hle-Ala-Gly-Cha-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131836
Gly-Hle-Ala-Gly-Ala(thiazol-4-yl)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131837
Gly-Cpa-Ala-Gly-Phe(3-Me)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131838
Gly-Cpa-Ala-Gly-Cha-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131839
Gly-Cpa-Ala-Gly-Ala(4-Py)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131840
Gly-Chg-Ala-Gly-Phe(3-Me)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131841
Gly-Chg-Ala-Gly-Tyr-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131842
Gly-Chg-Ala-Gly-Ala(4-Py)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131843
Gly-Ala(thiazol-4-yl)-Ala-Gly-Phe-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131844
Gly-Ala(thiazol-4-yl)-Ala-Gly-Phe(3-Me)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131847
Gly-Ala(thiazol-4-yl)-Ala-Gly-Ala(4-Py)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131848
Gly-Gln-Ala-Gly-Ala(thiazol-4-yl)-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131849
Gly-Gln-Ala-Gly-Phe-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131850
Gly-Gln-Ala-Gly-Tyr-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131851
Gly-Aic-Ala-Gly-Cha-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131852
Gly-Aic-Ala-Gly-Phe-Lys(5-GalO)-Gly-Glu-Gln-Gly-Pro-Lys-Gly-Glu-ThrQ27131853
P304page(s)e17881
P577publication date2011-03-15
P1433published inPLOS OneQ564954
P1476titleDesign of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis
P478volume6

Reverse relations

cites work (P2860)
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