A synopsis on the role of tyrosine hydroxylase in Parkinson's disease

scientific article

A synopsis on the role of tyrosine hydroxylase in Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2174/187152712800792785
P932PMC publication ID4978221
P698PubMed publication ID22483313

P50authorShams TabrezQ38323793
P2093author name stringAdel M Abuzenadah
Ghazi A Damanhouri
Nigel H Greig
Mohammad A Kamal
Shazi Shakil
Qamre Alam
Nasimudeen R Jabir
P2860cites workTyrosine hydroxylase and regulation of dopamine synthesisQ21710723
Parkinson's disease, pesticides, and glutathione transferase polymorphismsQ22004263
Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegansQ22251257
Glucagon-like peptide analogues for type 2 diabetes mellitusQ24235918
A role for alpha-synuclein in the regulation of dopamine biosynthesisQ24293727
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingQ24313304
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neuronsQ24336322
PGC-1α, a potential therapeutic target for early intervention in Parkinson's diseaseQ24597726
Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathwayQ24630617
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's diseaseQ24647189
Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylasesQ24648367
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodiesQ24653247
Glutamate and neurotrophic factors in neuronal plasticity and diseaseQ24653626
Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseasesQ27740782
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
Alpha-synuclein in Lewy bodiesQ27860680
A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles.Q27863413
Prospects for new restorative and neuroprotective treatments in Parkinson's diseaseQ28138668
alpha-Synuclein shares physical and functional homology with 14-3-3 proteinsQ28139698
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson diseaseQ28187904
Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegenerationQ28237641
Tyrosine hydroxylase and Parkinson's diseaseQ28273702
Tyrosine hydroxylaseQ28279680
Dopaminergic neuron-specific oxidative stress caused by dopamine itselfQ28285905
Biotechnology: Crossing the barrierQ28291058
The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideumQ44498627
Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotectionQ44937132
The prevalence of Parkinson's disease in an Arab population, Wadi Ara, Israel.Q45153652
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlationsQ45302799
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.Q45756120
Catalpol ameliorates beta amyloid-induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors.Q45918637
PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's diseaseQ46107948
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatmentQ46198761
In vitro phosphorylation of bovine adrenal chromaffin cell tyrosine hydroxylase by endogenous protein kinasesQ46202705
Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's diseaseQ46456058
Dopamine mimics the cardioprotective effect of ischemic preconditioning via activation of alpha1-adrenoceptors in the isolated rat heart.Q46460126
Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopaQ46578408
Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout miceQ46624242
Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's diseaseQ46691979
Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice.Q46698423
Estradiol increases tyrosine hydroxylase activity of the A15 nucleus dopaminergic neurons during long days in the ewe.Q48135889
Direct plasmid mediated transfection of adult murine brain cells in vivo using cationic liposomesQ48174573
Alpha-synuclein expression in substantia nigra and cortex in Parkinson's diseaseQ48198986
The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twinsQ48216713
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in miceQ43083221
The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects.Q43107113
9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's diseaseQ43111584
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylaseQ43185222
Responsiveness of motor and nonmotor symptoms of Parkinson disease to dopaminergic therapyQ43269023
Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamineQ43509401
Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent associationQ43612897
Nitration and inactivation of tyrosine hydroxylase by peroxynitriteQ43759048
A new splicing variant for human tyrosine hydroxylase in the adrenal medullaQ43767721
Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrainQ44295080
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.Q44442300
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia miceQ44493207
Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cellsQ48224712
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron lossQ48253717
Biochemical pathophysiology of Parkinson's disease.Q48258284
Particle bombardment-mediated gene transfer and expression in rat brain tissuesQ48317110
Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion.Q48388817
Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigraQ48452025
Mechanisms of MPTP toxicityQ48456918
Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic cultureQ48492176
Changes in tyrosine hydroxylase mRNA levels in medullary A1 and A2 neurons and locus coeruleus following castration and estrogen replacement in ratsQ48502064
Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.Q48546607
Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomesQ48766810
Change of tyrosine hydroxylase in the parkinsonian brain and in the brain of MPTP-treated mice as revealed by homospecific activityQ49046577
Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adultsQ49088676
Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's diseaseQ49153506
The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.Q51011184
Rosiglitazone decreases peroxisome proliferator receptor-γ levels in microglia and inhibits TNF-α production: new evidences on neuroprotection in a progressive Parkinson's disease model.Q52299253
Environmental antecedents of young-onset Parkinson's disease.Q52543483
Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.Q53439907
Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease.Q55044523
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumoursQ61761032
Reduced expression of the G209A alpha-synuclein allele in familial Parkinsonism.Q64855052
Activation and multiple-site phosphorylation of tyrosine hydroxylase in perfused rat adrenal glandsQ67512776
Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 yearQ68772556
beta-Carbolinium cations, endogenous MPP+ analogs, in the lumbar cerebrospinal fluid of patients with Parkinson's diseaseQ71631171
Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral applicationQ72226093
Parkinson's disease, environment and genesQ77599271
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive elementQ79838827
S100beta and fibroblast growth factor-2 are present in cultured Schwann cells and may exert paracrine actions on the peripheral nerve injuryQ82711679
Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicityQ83409927
Nonprofit disease groups earmark grants for drug repositioningQ84911156
Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseasesQ36330960
Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration--lessons from in vivo studies in mice and rats.Q36375506
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminalQ36455215
Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokinesQ36528609
Novel pharmacological targets for the treatment of Parkinson's diseaseQ36610996
Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cellsQ36700077
The role of stem cells in Parkinson's diseaseQ36716075
Multiple hit hypotheses for dopamine neuron loss in Parkinson's diseaseQ36785396
New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsyQ36803304
The role of anti-inflammatory agents in Parkinson's diseaseQ36938295
Message in a bottle: long-range retrograde signaling in the nervous systemQ37009283
Glutamate in dopamine neurons: synaptic versus diffuse transmissionQ37016446
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and ParkinsonismQ37078997
Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-αQ37109350
CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice.Q37121244
Pharmacological enhancement of neuronal survivalQ37146138
Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian ratsQ37162724
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive elementQ37166339
Paraquat and maneb induced neurotoxicityQ37208604
Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndromeQ37319535
Cell replacement therapy for Parkinson's diseaseQ37325157
Mendelian forms of Parkinson's diseaseQ37376999
Neuroprotective actions of sex steroids in Parkinson's diseaseQ37467662
Glutathione--a review on its role and significance in Parkinson's diseaseQ37525862
Inflammation in transgenic mouse models of neurodegenerative disordersQ37626195
Neurotrophic factor therapy for Parkinson’s diseaseQ37796025
The Role of GLP-1 in Neuronal Activity and NeurodegenerationQ37811420
GDNF and protection of adult central catecholaminergic neuronsQ37847791
Oxidation chemistry of catecholamines and neuronal degeneration: an updateQ37861824
Drug repositioning for orphan diseasesQ37866927
Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?Q37878285
Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug?Q37886152
A systematic review of the worldwide prevalence and incidence of Parkinson's disease.Q37893133
Genetic mutations and functions of PINK1.Q37904442
Allosteric regulation of phenylalanine hydroxylaseQ37946639
What genetics tells us about the causes and mechanisms of Parkinson's diseaseQ37947563
Initial motor symptoms of Parkinson diseaseQ37951820
In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardmentQ36299641
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug developmentQ36318080
Behind the rosiglitazone controversyQ37960108
Novel GLP-1 receptor agonists for diabetesQ37960149
Noninsulin treatment of type 2 diabetes mellitus in geriatric patients: a reviewQ37964088
Upcoming treatments in Parkinson's disease, including gene therapyQ37968070
Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcriptionQ38356055
Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cellsQ38473449
Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's diseaseQ38493912
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's diseaseQ39124093
Tyrosine hydroxylase. Activation by protein phosphorylation and end product inhibitionQ39175516
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterinQ39382909
Occupational exposures to metals as risk factors for Parkinson's diseaseQ39441603
Problems with long-term levodopa therapy for Parkinson's diseaseQ39487689
Alpha-synuclein functions as a negative regulator for expression of tyrosine hydroxylaseQ39508265
Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout miceQ39601884
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.Q39615697
Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatumQ39745332
Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults.Q39789685
Efficacy of Tyrosine Hydroxylase gene modified neural stem cells derived from bone marrow on Parkinson's disease--a rat model studyQ39861102
Absolute requirement of GDNF for adult catecholaminergic neuron survivalQ39974507
9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic cultureQ40072661
Dopamine release modifies intracellular calcium levels in tyrosine hydroxylase-transfected C6 cellsQ40097012
Effect of alpha-synuclein on the promoter activity of tyrosine hydroxylase geneQ40115210
The therapeutic effects of tyrosine hydroxylase gene transfected hematopoetic stem cells in a rat model of Parkinson's diseaseQ40181263
The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.Q40227332
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseQ40326219
Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cellsQ40395753
Long-term therapeutic effects on parkinsonian rats of intrastriatal co-grafts with genetically engineered fibroblasts expressing tyrosine hydroxylase and glial cell line-derived neurotrophic factorQ40397682
Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF.Q40519699
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cellsQ40748616
Evidence for mitochondrial dysfunction in Parkinson's disease--a critical appraisalQ40758643
Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situQ40772649
Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's diseaseQ40861090
Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson modelQ40941898
Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectorsQ40988268
Role of serine-19 phosphorylation in regulating tyrosine hydroxylase studied with site- and phosphospecific antibodies and site-directed mutagenesis.Q41006603
Intricate regulation of tyrosine hydroxylase activity and gene expressionQ41078672
Oxidative stress and antioxidant therapy in Parkinson's diseaseQ41130535
Oxidative stress and the pathogenesis of Parkinson's diseaseQ41262986
Epidemiologic study of Parkinson's disease in Hong KongQ41328143
Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites.Q41573867
Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's diseaseQ41917715
Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.Q42057712
Stimulation of endogenous L-dopa biosynthesis--a new principle for the therapy of Parkinson's disease. The clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH).Q42194018
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathwaysQ42502612
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.Q42524942
Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degenerationQ42685088
Discovery of an antiparkinsonian drug: zonisamideQ42726839
Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's diseaseQ43010410
MDR1, the blood-brain barrier transporter, is associated with Parkinson's disease in ethnic ChineseQ43073721
Tyrosine hydroxylase phosphorylation: regulation and consequencesQ28295531
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialQ28296434
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivoQ28306009
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trialQ28307713
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelQ28344741
Preventing levodopa-induced dyskinesiasQ28376608
Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleusQ28573001
Isoosmotic isolation of rat brain synaptic vesicles, some of which contain tyrosine hydroxylaseQ28582981
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disordersQ29614754
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Drug repositioning: identifying and developing new uses for existing drugsQ29614779
Biology of incretins: GLP-1 and GIPQ29617302
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer DiseaseQ30451794
Is NADH effective in the treatment of Parkinson's disease?Q30472795
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.Q30476321
Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicinesQ30478476
Localized striatal delivery of GDNF as a treatment for Parkinson diseaseQ31038741
The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safetyQ32133943
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.Q33292522
Parkinson's disease: current and future challengesQ33337881
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic interventionQ33663970
The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and PosiphenQ33790013
Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries.Q33832927
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesisQ33840243
Molecular basis of levodopa-induced dyskinesias.Q33890260
The aromatic amino acid hydroxylases.Q33900991
Chaperone-like activity of synucleinsQ33903337
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.Q33925878
Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant FormsQ33957484
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.Q34010256
Variability and validity of polymorphism association studies in Parkinson's diseaseQ34011134
Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cellsQ34028497
Approach to ex vivo gene therapy in the treatment of Parkinson's diseaseQ34031071
14-3-3 proteins: regulation of subcellular localization by molecular interferenceQ34127838
Pharmacogenomics of neurodegenerative diseasesQ34137788
Synucleinopathies: clinical and pathological implicationsQ34140347
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutantsQ34148293
Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotypeQ34158749
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.Q34167980
A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's diseaseQ34209755
Parkinson's disease--redox mechanismsQ34263075
Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literatureQ34273182
Dopamine neurons release transmitter via a flickering fusion poreQ34301975
Pesticides and risk of Parkinson disease: a population-based case-control studyQ34383364
Recent advances in the genetics and pathogenesis of Parkinson diseaseQ34502910
Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of CaliforniaQ34605203
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.Q34646166
Environmental factors in Parkinson's diseaseQ34995010
Catecholamine metabolism: an update on key biosynthetic enzymes and vesicular monoamine transportersQ35001393
Dopamine in crayfish and other crustaceans: distribution in the central nervous system and physiological functionsQ35050005
The glucagon-like peptides: a double-edged therapeutic sword?Q35181801
The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeysQ35196195
Gene therapy progress and prospects: Parkinson's diseaseQ35206326
Reactive oxygen species and the central nervous systemQ35389986
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cellsQ35492403
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's diseaseQ35552497
The human tyrosine hydroxylase geneQ35574200
Insulin and neurodegenerative disease: shared and specific mechanismsQ35674377
Reactive oxygen species as mediators of signal transduction in ischemic preconditioningQ35693492
Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathyQ35748345
Alpha-synuclein and the pathogenesis of Parkinson's diseaseQ35795168
Toxin models of mitochondrial dysfunction in Parkinson's disease.Q35799141
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?Q35800096
The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expressionQ36012226
Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implicationsQ36102771
Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disordersQ36166654
Structural changes in alpha-synuclein affect its chaperone-like activity in vitroQ36281848
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)395-409
P577publication date2012-06-01
P1433published inCNS and Neurological DisordersQ15724632
P1476titleA synopsis on the role of tyrosine hydroxylase in Parkinson's disease
P478volume11

Reverse relations

cites work (P2860)
Q90348452"New methods of assessing autonomic disorders in Parkinson disease patients: skin-galvanic reaction"
Q47891276A Single Neonatal Exposure to BMAA in a Rat Model Produces Neuropathology Consistent with Neurodegenerative Diseases
Q42173539An exploratory evaluation of tyrosine hydroxylase inhibition in planaria as a model for parkinsonism
Q34800195An overview on the correlation of neurological disorders with cardiovascular disease
Q38700215Beyond muscles: The untapped potential of creatine
Q38269376Cannabinoids: new promising agents in the treatment of neurological diseases
Q89452010Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum
Q64055243Effect of Majun Baladur on life span, climbing ability, oxidative stress and dopaminergic neurons in the transgenic model of Parkinson's disease
Q42178747Effects of Nogo-A Silencing on TNF-α and IL-6 Secretion and TH Downregulation in Lipopolysaccharide-Stimulated PC12 Cells
Q27304699Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.
Q33722420Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease
Q92051615Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Q37066046Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor
Q91722847Multigenerational metabolic profiling in the Michigan PBB registry
Q47905973Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson's Disease Are Related to Its Anti-Inflammatory Effects
Q35808114Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease.
Q58799123Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain
Q36154563Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson's Disease
Q90038947Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury
Q38854898Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss
Q38805550Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.
Q26771824The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress
Q33872721The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats.
Q30832756Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.
Q60048467Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice
Q35623461Valproic Acid Neuroprotection in the 6-OHDA Model of Parkinson's Disease Is Possibly Related to Its Anti-Inflammatory and HDAC Inhibitory Properties
Q89684847[Association of microRNA expression before and after drug therapy with clinical symptoms in children with attention deficit hyperactivity disorder]

Search more.