| scholarly article | Q13442814 |
| P2093 | author name string | L K Cohen | |
| S K Spratt | |||
| R O Snyder | |||
| R J Mandel | |||
| S E Leff | |||
| K G Rendahl | |||
| P2860 | cites work | Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme | Q24317596 |
| Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors | Q24682739 | ||
| Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) | Q28202629 | ||
| Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis | Q49156811 | ||
| Amphetamine induces excess release of striatal acetylcholine in vivo that is independent of nigrostriatal dopamine. | Q51627326 | ||
| Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease | Q64383353 | ||
| Tyrosine hydroxylase cofactor (tetrahydrobiopterin) in parkinsonism | Q64763391 | ||
| Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism | Q64785711 | ||
| The decarboxylation of DOPA in the parkinsonian brain: in vivo studies on an animal model | Q64814733 | ||
| The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes | Q70136807 | ||
| 1 Production of antibodies by inoculation into lymph nodes | Q70264885 | ||
| The site of dopamine formation in rat striatum after L-dopa administration | Q70692345 | ||
| Diminished decarboxylation of L-DOPA in rat striatum after intrastriatal injections of kainic acid | Q71220298 | ||
| Decarboxylation of exogenous L-DOPA in rat striatum after lesions of the dopaminergic nigrostriatal neurons: the role of striatal capillaries | Q71291733 | ||
| Aromatic L-amino acid decarboxylase immunoreactive cells in the rat striatum: a possible site for the conversion of exogenous L-DOPA to dopamine | Q71377846 | ||
| Neural Transplantation | Q71796889 | ||
| Behavioral effects and gene delivery in a rat model of Parkinson's disease | Q71967787 | ||
| Production of reagent antibodies | Q72153598 | ||
| Rotation and striatal c-fos expression after repeated, daily treatment with selective dopamine receptor agonists and levodopa | Q72335381 | ||
| Use of a new fluorogenic phosphatase substrate in immunohistochemical applications | Q72412405 | ||
| Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat | Q72534294 | ||
| Tetrahydrobiopterin uptake into rat brain synaptosomes, cultured PC12 cells, and rat striatum | Q72610139 | ||
| Chronic continuous and intermittent L-3,4-dihydroxyphenylalanine treatments differentially affect basal ganglia function in 6-hydroxydopamine lesioned rats--an autoradiographic study using [3H]flunitrazepam | Q72776573 | ||
| The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson's disease | Q72784582 | ||
| Estimation of nuclear population from microtome sections | Q82126847 | ||
| Hydroxylase Cofactor Activity in Cerebrospinal Fluid of Normal Subjects and Patients with Parkinson's Disease | Q28326297 | ||
| NeuN, a neuronal specific nuclear protein in vertebrates | Q28510657 | ||
| In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector | Q29547503 | ||
| Suppression of dyskinesias in advanced Parkinson's disease. I. Continuous intravenous levodopa shifts dose response for production of dyskinesias but not for relief of parkinsonism in patients with advanced Parkinson's disease | Q30467172 | ||
| Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats | Q33745707 | ||
| Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease | Q34320662 | ||
| Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells | Q35228018 | ||
| Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy | Q35232341 | ||
| Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. | Q35891440 | ||
| Neural transplantation — an experimental tool with clinical possibilities | Q36705207 | ||
| Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression | Q36830429 | ||
| Rationale for continuous dopaminomimetic therapy of Parkinson's disease | Q38726345 | ||
| Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease | Q39111166 | ||
| The regional distribution of hydroxylase cofactor in rat brain | Q39248773 | ||
| Clinical application of cell transplantation and neurotrophic factors in CNS disorders | Q39481317 | ||
| The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. | Q39540612 | ||
| Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. | Q39644710 | ||
| Grafting genetically modified cells to the brain: possibilities for the future | Q39694407 | ||
| Nonaminergic striatal neurons convert exogenous l-dopa to dopamine in parkinsonism | Q40123863 | ||
| Motor response complications and the function of striatal efferent systems | Q40792411 | ||
| A defective herpes simplex virus vector system for gene delivery into the brain: comparison with alternative gene delivery systems and usefulness for gene therapy. | Q41207845 | ||
| Adeno-associated virus vectors for gene therapy of neurodegenerative disorders | Q41207868 | ||
| Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA | Q41649774 | ||
| Biopterin in human brain and urine from controls and parkinsonian patients: Application of a new radioimmunoassay | Q42241168 | ||
| Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain | Q42280576 | ||
| Endogenous release of neuronal serotonin and 5-hydroxyindoleacetic acid in the caudate-putamen of the rat as revealed by intracerebral dialysis coupled to high-performance liquid chromatography with fluorimetric detection. | Q42489395 | ||
| In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex | Q42800196 | ||
| In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase | Q42828882 | ||
| Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase | Q43185222 | ||
| Continuous and intermittent levodopa differentially affect rotation induced by D-1 and D-2 dopamine agonists | Q43586953 | ||
| Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors | Q43716886 | ||
| Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats | Q43982583 | ||
| Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector | Q45769447 | ||
| Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism | Q45830933 | ||
| Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts | Q45877347 | ||
| Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer | Q45879174 | ||
| Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro | Q48091122 | ||
| Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease | Q48405890 | ||
| Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease | Q48405897 | ||
| Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum | Q48594848 | ||
| Catecholamine-related enzymes and the biopterin cofactor in Parkinson's disease and related extrapyramidal diseases | Q48697219 | ||
| Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra | Q48713669 | ||
| Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism | Q48838774 | ||
| Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. | Q48876521 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Parkinson's disease | Q11085 |
| P1104 | number of pages | 14 | |
| P304 | page(s) | 4271-4284 | |
| P577 | publication date | 1998-06-01 | |
| P1433 | published in | Journal of Neuroscience | Q1709864 |
| P1476 | title | Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease | |
| P478 | volume | 18 |
| Q36006011 | A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. |
| Q36458373 | A rat model of human immunodeficiency virus 1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors |
| Q28830946 | A synopsis on the role of tyrosine hydroxylase in Parkinson's disease |
| Q29616120 | A third-generation lentivirus vector with a conditional packaging system |
| Q61976265 | AAV for disorders of the CNS |
| Q45885520 | AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL. |
| Q92069614 | Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation |
| Q35216667 | Adeno-associated viral vectors for Parkinson's disease |
| Q35216648 | Adeno-associated viral vectors. |
| Q40994121 | Adeno-associated virus expression systems for gene transfer |
| Q45740016 | Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system |
| Q33958498 | Adeno-associated virus vectors: activity and applications in the CNS. |
| Q44420155 | Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease |
| Q34656049 | Advances in gene therapy for movement disorders. |
| Q34987177 | Application of adeno-associated viral vectors in behavioral research |
| Q34003138 | Cellular transplants as sources for therapeutic agents |
| Q34193457 | Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain |
| Q36969314 | Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behaviora |
| Q36989384 | Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease |
| Q35582092 | Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease |
| Q36969304 | Correction of a Rat Model of Parkinson's Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type 1 Vector |
| Q36085361 | Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease |
| Q44205892 | Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin. |
| Q41848062 | Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis |
| Q45222289 | Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy |
| Q28504725 | Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice |
| Q42856452 | Efficient CNS gene delivery by intravenous injection |
| Q45408947 | Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector. |
| Q37696495 | Future of cell and gene therapies for Parkinson's disease |
| Q34179305 | Gene delivery and gene therapy with herpes simplex virus-based vectors |
| Q36450108 | Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases |
| Q34446012 | Gene therapy against neurological insults: sparing neurons versus sparing function |
| Q34997896 | Gene therapy for the central nervous system in the lysosomal storage disorders |
| Q38166648 | Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications |
| Q33837123 | Gene therapy in the CNS. |
| Q33899454 | Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors. |
| Q45081316 | Gene transfer to the cerebellum |
| Q45867822 | Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe |
| Q26851517 | Gene-based therapy of Parkinson's Disease: Translation from animal model to human clinical trial employing convection enhanced delivery |
| Q44235491 | Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer |
| Q35216671 | Herpes simplex virus vectors for Parkinson's disease |
| Q31023442 | Human gene therapy and imaging in neurological diseases |
| Q36498773 | Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions |
| Q45869654 | Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain |
| Q45870327 | Intracisternal rSV40 administration provides effective pan-CNS transgene expression |
| Q37131550 | Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice |
| Q37265519 | Large animal models of neurological disorders for gene therapy |
| Q36364923 | Lentiviral vectors for use in the central nervous system. |
| Q45869731 | Long-Term Neuronal Effects and Disposition of Ectopic preproNGF Gene Transfer into the Rat Septum |
| Q35734505 | Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson's disease. |
| Q40874496 | Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. |
| Q43535625 | Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease |
| Q35550669 | Metabolic Engineering: Advances in Modeling and Intervention in Health and Disease |
| Q43614803 | Mitosis and apoptosis in postnatal auditory system of the C3H/He strain |
| Q34657654 | Models of repair mechanisms for future treatment modalities of Parkinson's disease. |
| Q35563389 | Molecular biology and gene therapy in the treatment of chronic pain. |
| Q78571001 | Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat |
| Q33802664 | Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction |
| Q36335033 | Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity |
| Q43940212 | Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. |
| Q45883004 | Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy. |
| Q38964909 | Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration |
| Q34070162 | Production of recombinant adeno-associated virus |
| Q37140794 | Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors |
| Q34987192 | Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain |
| Q45871733 | Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors |
| Q45007196 | Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system |
| Q36368045 | Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. |
| Q35111738 | Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. |
| Q34987182 | Recombinant adeno-associated virus vector design and gene expression in the mammalian brain |
| Q34361466 | Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders |
| Q42827352 | Regulation of gene expression in vivo following transduction by two separate rAAV vectors |
| Q31045537 | Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer |
| Q28576511 | Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage |
| Q36707975 | Simple Purification of Adeno-Associated Virus-DJ for Liver-Specific Gene Expression |
| Q45867412 | Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors |
| Q45236560 | Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion |
| Q42571006 | Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease |
| Q39737653 | The degenerating substantia nigra as a susceptible region for gene transfer-mediated inflammation. |
| Q39617892 | The vesicular glutamate transporter-1 upstream promoter and first intron each support glutamatergic-specific expression in rat postrhinal cortex |
| Q45868778 | Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. |
| Q34105795 | Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model |
| Q45890373 | Towards gene therapy for the central nervous system |
| Q36448393 | Treatment of human disease by adeno-associated viral gene transfer |
| Q45857411 | Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase enhance dopamine delivery after L-3, 4-dihydroxyphenylalanine administration in Parkinsonian rats. |
| Q64381642 | Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice |
| Q56947120 | Viral vector-mediated gene therapy for Parkinson's disease |
| Q40369273 | Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease |
| Q39611260 | Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector |
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