scholarly article | Q13442814 |
review article | Q7318358 |
P356 | DOI | 10.1016/S0074-7742(03)01010-9 |
P698 | PubMed publication ID | 12968539 |
P2093 | author name string | David S Latchman | |
P2860 | cites work | Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Q22254584 |
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 | ||
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons | Q24336322 | ||
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies | Q24653247 | ||
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease | Q64383353 | ||
The genetics of Parkinson's disease | Q64782384 | ||
Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro | Q73683636 | ||
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 | ||
Alpha-synuclein in Lewy bodies | Q27860680 | ||
Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) | Q28202629 | ||
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system | Q28594502 | ||
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease | Q29547175 | ||
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders | Q29614754 | ||
Association between early-onset Parkinson's disease and mutations in the parkin gene | Q29615733 | ||
A Drosophila model of Parkinson's disease | Q29617052 | ||
Transplantation of embryonic dopamine neurons for severe Parkinson's disease | Q29617304 | ||
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma | Q33905047 | ||
Gene delivery and gene therapy with herpes simplex virus-based vectors | Q34179305 | ||
Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse | Q34308944 | ||
Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence | Q34779144 | ||
Human gene therapy comes of age. | Q36220668 | ||
Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo | Q36457858 | ||
Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. | Q36561684 | ||
Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression | Q36827546 | ||
Herpes simplex virus type 1 ICP27 is an essential regulatory protein. | Q36904843 | ||
Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription | Q38310979 | ||
Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor | Q38336118 | ||
An inquiry into the mechanisms of herpes simplex virus latency | Q39159400 | ||
Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease | Q39519102 | ||
Equine herpesvirus 1 gene 12 can substitute for vmw65 in the growth of herpes simplex virus (HSV) type 1, allowing the generation of optimized cell lines for the propagation of HSV vectors with multiple immediate-early gene defects | Q39550929 | ||
Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system | Q39591444 | ||
Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration | Q40805293 | ||
Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo | Q40814855 | ||
Genetic dissection of familial Parkinson's disease | Q40837761 | ||
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease | Q40929764 | ||
High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5. | Q40954651 | ||
Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector | Q40973614 | ||
Gene transfer to neurons using herpes simplex virus-based vectors | Q41132657 | ||
Prospects for gene therapy in Parkinson's disease | Q41159915 | ||
Biology of glial cell line-derived neurotrophic factor (GDNF): implications for the use of GDNF to treat Parkinson's disease | Q41169846 | ||
Therapeutic potentials for glial cell line-derived neurotrophic factor (GDNF) based upon pharmacological activities in the CNS. | Q41186665 | ||
Fetal nigral transplantation as a therapy for Parkinson's disease | Q41367101 | ||
Potential use of herpes simplex virus (HSV) vectors for gene therapy of neurological disorders | Q41543685 | ||
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain | Q42280576 | ||
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase | Q43185222 | ||
Pathways of viral gene expression during acute neuronal infection with HSV-1 | Q44933537 | ||
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. | Q45756120 | ||
Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts | Q45877347 | ||
Intracerebral recombinant HSV-1 vector does not reactivate latent HSV-1. | Q45885582 | ||
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons | Q46135759 | ||
Induction of midbrain dopaminergic neurons by Sonic hedgehog | Q46258125 | ||
The ubiquitin pathway in Parkinson's disease | Q48015939 | ||
Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. | Q54647282 | ||
Synucleins in synaptic plasticity and neurodegenerative disorders | Q62055336 | ||
P921 | main subject | Parkinson's disease | Q11085 |
vector-borne disease | Q2083837 | ||
P304 | page(s) | 223-241 | |
P577 | publication date | 2003-01-01 | |
P1433 | published in | International Review of Neurobiology | Q15754273 |
P1476 | title | Herpes simplex virus vectors for Parkinson's disease | |
P478 | volume | 55 |