Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe

scientific article published on 3 March 2011

Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1036353434
P356DOI10.1038/GT.2011.13
P698PubMed publication ID21368898
P5875ResearchGate publication ID50267780

P2093author name stringB A Bunnell
J P Dufour
D S Strayer
E Marusich
J Fisher-Perkins
J-P Louboutin
P2860cites workProtecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectorsQ45871733
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Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeysQ48325968
Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineagesQ48425921
Using gene delivery to protect HIV-susceptible CNS cells: inhibiting HIV replication in microglia.Q48687135
Transfer of a foreign gene into the brain using adenovirus vectorsQ64377820
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Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeysQ82240782
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Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler miceQ33261656
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Gene therapy using SV40-derived vectors: what does the future hold?Q33755140
Beyond the olfactory bulb: an odotopic map in the forebrain.Q34234461
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Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease.Q37181003
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vectorQ37251114
Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brainQ37398172
Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeysQ37399627
Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's diseaseQ39863620
Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosisQ40251050
Gene therapy for human alpha1-antitrypsin deficiency in an animal model using SV40-derived vectorsQ40504864
Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteinsQ40583034
Inhibition of HIV-1 in the central nervous system by IFN-alpha2 delivered by an SV40 vector.Q40625143
Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.Q40723341
A replication-deficient rSV40 mediates liver-directed gene transfer and a long-term amelioration of jaundice in gunn ratsQ40845754
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of β-glucuronidaseQ41102578
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.Q42463227
Efficient CNS gene delivery by intravenous injectionQ42856452
X-linked vacuolated myopathy : TNF-alpha and IFN-gamma expression in muscle fibers with MHC class I on sarcolemmaQ42856618
Lentiviral gene transfer to the nonhuman primate brainQ44028201
Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer.Q44267005
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatumQ44631221
Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transferQ44747875
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemQ45007196
Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle.Q45270141
Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoproteinQ45399638
Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brainQ45418748
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.Q45756120
Gene transfer to rodent brain with recombinant adenoviral vectors: effects of infusion parameters, infectious titer, and virus concentration on transduction volumeQ45757267
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vectorQ45769447
Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleusQ45861874
Inhibiting AIDS in the central nervous system: gene delivery to protect neurons from HIV.Q45862705
Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice.Q45864505
Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectorsQ45867412
Efficient gene transfer to hematopoietic progenitor cells using SV40-derived vectorsQ45868429
P433issue7
P304page(s)682-691
P577publication date2011-03-03
P1433published inGene TherapyQ15763095
P1476titleGene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe
P478volume18

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cites work (P2860)
Q52623530Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications.
Q54210508Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40.
Q57300366Effect of dsDNA on the Assembly Pathway and Mechanical Strength of SV40 VP1 Virus-like Particles
Q36450108Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
Q38695385Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies.
Q45870327Intracisternal rSV40 administration provides effective pan-CNS transgene expression
Q96135637Revealing in real-time a multistep assembly mechanism for SV40 virus-like particles
Q26829535Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes
Q27023715The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?

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