Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy

scientific article published in February 2001

Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1041065347
P356DOI10.1038/84448
P698PubMed publication ID11175734

P2093author name stringLundberg C
Mulligan RC
Jungles SJ
P2860cites workSubventricular zone astrocytes are neural stem cells in the adult mammalian brainQ28137965
Serum immunoreactive-leptin concentrations in normal-weight and obese humansQ29617230
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjectsQ29617231
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptinQ33735882
Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in ratsQ33745707
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin actionQ34289416
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistanceQ34386993
Selective and rapid uptake of adeno-associated virus type 2 in brainQ34471578
Identification of a neural stem cell in the adult mammalian central nervous systemQ34492720
An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgeneQ36163092
Physiological response to long-term peripheral and central leptin infusion in lean and obese miceQ36564953
The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.Q39540612
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent miceQ44678756
Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.Q45756120
Recombinant adeno-associated virus for muscle directed gene therapyQ45764433
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vectorQ45769447
Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trialQ47254016
P433issue2
P921main subjectvector-borne diseaseQ2083837
P304page(s)169-172
P577publication date2001-02-01
P1433published inNature BiotechnologyQ1893837
P1476titleDirect delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy
P478volume19

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Q47342408Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases
Q34997896Gene therapy for the central nervous system in the lysosomal storage disorders
Q38361454Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses
Q36236088Leptin: structure, function and biology
Q47103932Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Q45340200Overexpression of CART in the PVN increases food intake and weight gain in rats
Q36512376Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome
Q34769911Potential new methods for antiepileptic drug delivery
Q95643265Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies
Q36448393Treatment of human disease by adeno-associated viral gene transfer

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