| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0361-9230(01)00773-0 |
| P698 | PubMed publication ID | 12031282 |
| P50 | author | Ole Isacson | Q67215582 |
| P2093 | author name string | Ole Isacson | |
| P2860 | cites work | Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis | Q22242250 |
| GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons | Q24336322 | ||
| Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue | Q24523651 | ||
| The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals | Q24645277 | ||
| Embryonic stem cell lines derived from human blastocysts | Q27861010 | ||
| Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux | Q28270468 | ||
| Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family | Q28295196 | ||
| Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo | Q28306009 | ||
| Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model | Q28344741 | ||
| Chronic systemic pesticide exposure reproduces features of Parkinson's disease | Q29614763 | ||
| Transplantation of embryonic dopamine neurons for severe Parkinson's disease | Q29617304 | ||
| Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats | Q33745707 | ||
| Development of a self-inactivating lentivirus vector. | Q33784841 | ||
| Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion | Q33939425 | ||
| Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult | Q33964044 | ||
| Pathoanatomy of Parkinson's disease | Q34035667 | ||
| Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease | Q44808814 | ||
| Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system | Q44902306 | ||
| Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine | Q44905114 | ||
| Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination | Q44907561 | ||
| Basal ganglia disease | Q45303735 | ||
| Drug inducible transgene expression in brain using a herpes simplex virus vector | Q45755731 | ||
| Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. | Q45756120 | ||
| Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors | Q45756988 | ||
| Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity | Q45762593 | ||
| Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters | Q45764253 | ||
| Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo | Q45772275 | ||
| Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. | Q45876510 | ||
| Gene therapy -- promises, problems and prospects | Q45883584 | ||
| Tetracycline-responsive gene expression in mouse brain after amplicon-mediated gene transfer | Q45884065 | ||
| Immune parameters affecting adenoviral vector gene therapy in the brain. | Q45887138 | ||
| Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. | Q46172163 | ||
| Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle trans | Q46504121 | ||
| Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs | Q48140006 | ||
| Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine | Q48165295 | ||
| Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. | Q48196753 | ||
| Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. | Q48198394 | ||
| Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures | Q48225542 | ||
| Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons--I. Effects in vitro. | Q48229447 | ||
| Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss | Q48262632 | ||
| Lipid peroxidation as cause of nigral cell death in Parkinson's disease | Q48299872 | ||
| Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. | Q48353766 | ||
| Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture | Q48387075 | ||
| Herpes simplex virus type 1-based amplicon vector systems | Q34070145 | ||
| Embryonic stem cells go dopaminergic | Q34087216 | ||
| Vertebrate embryonic cells will become nerve cells unless told otherwise | Q34415315 | ||
| Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia | Q35160653 | ||
| Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo | Q35754302 | ||
| Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector | Q35757133 | ||
| Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo | Q36406386 | ||
| Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. | Q36412788 | ||
| Coexpression of neurotrophins and their receptors in neurons of the central nervous system | Q36427306 | ||
| Parkinson's disease: pathophysiology | Q36495393 | ||
| Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. | Q36561684 | ||
| Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity | Q36614722 | ||
| Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo | Q37319917 | ||
| A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Q37343442 | ||
| Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. | Q37390129 | ||
| What, if anything, is a neurotrophic factor? | Q38201339 | ||
| Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient | Q39434658 | ||
| Mechanisms of neurotrophic factor protection against calcium- and free radical-mediated excitotoxic injury: implications for treating neurodegenerative disorders | Q40801575 | ||
| The neurotrophic factor concept: a reexamination. | Q40825310 | ||
| Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein | Q40842217 | ||
| Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease | Q40846012 | ||
| Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain | Q41100334 | ||
| Structural and functional heterogeneity of integrated recombinant AAV genomes | Q41118391 | ||
| NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis | Q41131864 | ||
| A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor | Q41141528 | ||
| Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists | Q41154685 | ||
| Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium. | Q41257274 | ||
| Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. | Q41345669 | ||
| Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression | Q41355829 | ||
| Fetal nigral transplantation as a therapy for Parkinson's disease | Q41367101 | ||
| GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo | Q41368638 | ||
| Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain | Q41379201 | ||
| MPTP, MPP+ and mitochondrial function | Q41382377 | ||
| Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. | Q41397008 | ||
| Transforming growth factor-beta promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity | Q41424070 | ||
| Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo | Q41428400 | ||
| TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons | Q41431348 | ||
| Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease | Q41450672 | ||
| Recombinant adenovirus: a gene transfer vector for study and treatment of CNS diseases | Q41450717 | ||
| A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease | Q41540972 | ||
| Neural transplantation studies reveal the brain's capacity for continuous reconstruction. | Q41623996 | ||
| New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors | Q41634721 | ||
| Mitochondrial complex I deficiency in Parkinson's disease | Q41821730 | ||
| Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain | Q42280576 | ||
| Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system | Q42458072 | ||
| Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum | Q42480727 | ||
| Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigrostriatal pathway using a nonreplicating herpes simplex vector | Q42517893 | ||
| Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores | Q42799708 | ||
| Regulation of gene expression in vivo following transduction by two separate rAAV vectors | Q42827352 | ||
| Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase | Q43185222 | ||
| Protection from 1-methyl-4-phenylpyridinium (MPP+) toxicity and stimulation of regrowth of MPP(+)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF | Q44115340 | ||
| Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. | Q44156744 | ||
| Brain Peroxidase and Catalase in Parkinson Disease | Q44295221 | ||
| Neural induction by the secreted polypeptide noggin | Q44628705 | ||
| Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system | Q48459449 | ||
| Glutathione peroxidase activity in Parkinson's disease brain | Q48462475 | ||
| Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine | Q48477579 | ||
| Glutamate receptors in the substantia nigra of Parkinson's disease brains | Q48529351 | ||
| Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in ventral midbrain regions containing dopaminergic neurons | Q48530861 | ||
| Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. | Q48546607 | ||
| The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia | Q48641595 | ||
| Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice | Q48655550 | ||
| An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain | Q48723498 | ||
| BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra | Q48767968 | ||
| Parkinson's disease: interpretations of transplantation study are erroneous. | Q48872040 | ||
| Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration | Q49095981 | ||
| The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. | Q52880163 | ||
| Is Alzheimer disease caused by lack of nerve growth factor? | Q53309643 | ||
| A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain | Q56427932 | ||
| Parkin is associated with actin filaments in neuronal and nonneural cells | Q58856664 | ||
| Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia | Q59054547 | ||
| Adenovirus gene transfer causes inflammation in the brain | Q64383186 | ||
| Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease | Q64383353 | ||
| Mitochondrial oxidative phosphorylation defects in Parkinson's disease | Q68060626 | ||
| Abnormalities of the electron transport chain in idiopathic Parkinson's disease | Q69361952 | ||
| Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer | Q69439268 | ||
| The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve | Q71511614 | ||
| Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions | Q71638153 | ||
| Intrastriatal Infusions of Brain-Derived Neurotrophic Factor: Retrograde Transport and Colocalization with Dopamine Containing Substantia Nigra Neurons in Rat | Q71650088 | ||
| Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons | Q71748788 | ||
| In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]NT-3 | Q71986609 | ||
| Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A | Q73206046 | ||
| P433 | issue | 6 | |
| P921 | main subject | Parkinson's disease | Q11085 |
| P304 | page(s) | 839-846 | |
| P577 | publication date | 2002-04-01 | |
| P1433 | published in | Brain Research Bulletin | Q4955784 |
| P1476 | title | Models of repair mechanisms for future treatment modalities of Parkinson's disease | |
| P478 | volume | 57 |
| Q46610659 | Bcl-x is required for proper development of the mouse substantia nigra. |
| Q35810593 | Cell transplantation for Parkinson's disease: present status |
| Q36012093 | Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease |
| Q36161877 | Environmental toxins and alpha-synuclein in Parkinson's disease |
| Q36919403 | Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention |
| Q35116171 | Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics |
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