| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NM0497-421 |
| P698 | PubMed publication ID | 9095176 |
| P50 | author | Solomon Halbert Snyder | Q1681665 |
| P2093 | author name string | T M Dawson | |
| G S Hamilton | |||
| J P Steiner | |||
| M A Connolly | |||
| L Hester | |||
| H L Valentine | |||
| P2860 | cites work | A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase | Q72082900 |
| The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury | Q84063617 | ||
| Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence | Q22001507 | ||
| A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase | Q24296311 | ||
| A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin | Q28238996 | ||
| A mammalian protein targeted by G1-arresting rapamycin-receptor complex | Q28243712 | ||
| Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes | Q28277749 | ||
| RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs | Q28286431 | ||
| Cyclophilin: a specific cytosolic binding protein for cyclosporin A | Q29620548 | ||
| Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin | Q33911404 | ||
| Kidney transplantation under FK 506 | Q34302082 | ||
| Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand | Q34569267 | ||
| Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia | Q35160653 | ||
| Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models | Q36030904 | ||
| Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? | Q36229942 | ||
| The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin | Q36231731 | ||
| Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands | Q36617985 | ||
| A Putative Sirolimus (Rapamycin) Effector Protein | Q38305182 | ||
| Immunophilins and nervous system | Q40429841 | ||
| CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomized cholinergic neurons after transplantation into the septum. | Q41317097 | ||
| Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay | Q42116501 | ||
| Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections | Q42525515 | ||
| Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. | Q46628726 | ||
| Nerve growth factor administration protects against experimental diabetic sensory neuropathy | Q48190313 | ||
| High brain densities of the immunophilin FKBP colocalized with calcineurin | Q48445337 | ||
| Nerve growth factor prevents experimental cisplatin neuropathy | Q68068322 | ||
| The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve | Q71511614 | ||
| Neuronal regeneration enhances the expression of the immunophilin FKBP-12 | Q71689229 | ||
| P433 | issue | 4 | |
| P921 | main subject | sirolimus | Q32089 |
| cyclosporine | Q367700 | ||
| P304 | page(s) | 421-428 | |
| P577 | publication date | 1997-04-01 | |
| P1433 | published in | Nature Medicine | Q1633234 |
| P1476 | title | Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A | |
| P478 | volume | 3 |
| Q78444401 | 3-Normeridamycin: A Potent Non-Immunosuppressive Immunophilin Ligand is Neuroprotective in Dopaminergic Neurons |
| Q34293913 | A calcium-initiated signaling pathway propagated through calcineurin and cAMP response element-binding protein activates proenkephalin gene transcription after depolarization |
| Q48467202 | A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration |
| Q35136262 | A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus |
| Q48273676 | Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo |
| Q48481767 | Binding capacity of FK506 binding protein after 2-hour hemispheric ischemia in gerbil brain |
| Q36423536 | Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities |
| Q73635011 | Biochemical characterization of the minor immunophilins |
| Q37768655 | Biosynthesis of rapamycin and its regulation: past achievements and recent progress |
| Q33500614 | Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals |
| Q44225298 | Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity |
| Q33923323 | Brain ischemia and reperfusion: molecular mechanisms of neuronal injury |
| Q34120215 | Calcineurin determines toxic versus beneficial responses to α-synuclein |
| Q38871364 | Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach |
| Q34236648 | Calcineurin inhibitors and the generalization of the presenting protein strategy |
| Q48291182 | Cellular activation in neuroregeneration |
| Q86055488 | Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production |
| Q60395558 | Chemistry and Pharmacology of Rapamycin and Its Derivatives |
| Q48315550 | Chronic cyclosporine-A injection in rats with damaged blood-brain barrier does not impair retention of passive avoidance |
| Q41622539 | Clinical and molecular aspects of motoneurone diseases: animal models, neurotrophic factors and Bcl-2 oncoprotein |
| Q48502049 | Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons |
| Q28582105 | Cyclophilin C-associated protein and cyclophilin C mRNA are upregulated in penumbral neurons and microglia after focal cerebral ischemia |
| Q43580847 | Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord |
| Q48436702 | Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. |
| Q43581358 | Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. |
| Q36370618 | Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease |
| Q73448107 | Cyclosporine-A enhances choline acetyltransferase immunoreactivity in the septal region of adult rats |
| Q52176259 | Cyclosporine-A reduces spontaneous place preference in adult rats. |
| Q27642434 | Design and Structure-Based Study of New Potential FKBP12 Inhibitors |
| Q33846578 | Development of pharmacological agents for targeting neurotrophins and their receptors |
| Q42468133 | Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells |
| Q44026113 | Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis |
| Q48286368 | Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia |
| Q33918132 | Effect Of combining FK506 and neurotrophins on neurite branching and elongation |
| Q44515303 | Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons |
| Q40794403 | Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells |
| Q43856191 | Effects of immunophilin ligands on hydrogen peroxide-induced apoptosis in C6 glioma cells |
| Q52567159 | Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle. |
| Q33195912 | Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. |
| Q48474182 | Effects of repeated cyclosporin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain |
| Q41032257 | Experience with nerve allograft transplantation |
| Q43656855 | FK506 ameliorates the discrimination learning impairment due to preventing the rarefaction of white matter induced by chronic cerebral hypoperfusion in rats |
| Q41697821 | FK506 and the role of immunophilins in nerve regeneration |
| Q28580429 | FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury |
| Q44574725 | FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers |
| Q38489415 | FK506-Binding Proteins and Their Diverse Functions |
| Q47304900 | FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome |
| Q44462466 | FKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain |
| Q24336083 | FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines |
| Q34463962 | FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle |
| Q35130192 | Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist, Cereport. |
| Q44687922 | Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice |
| Q42931990 | GPI-1046 Increases Presenilin-1 Expression and Restores NMDA Channel Activity |
| Q41726588 | Generation and evaluation of putative neuroregenerative drugs. Part 1: virtual point mutations to the polyketide rapamycin |
| Q92813735 | Glial Cells-The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment |
| Q44643288 | High-Throughput Fluorescence Polarization Method for Identification of FKBP12 Ligands |
| Q35620197 | Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci |
| Q36158083 | Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line |
| Q43759209 | Immunophilin ligand FK506 is neuroprotective for penile innervation |
| Q77206295 | Immunophilins in the nervous system |
| Q40653555 | Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain |
| Q31885597 | Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells |
| Q34120728 | Improving the survival of grafted embryonic dopamine neurons in rodent models of Parkinson's disease |
| Q44345666 | In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions |
| Q77534788 | Increase of nerve regeneration capacity by new neurotrophic pyrimidine derivative MS-430 |
| Q48415816 | Inhibition of arachidonic acid release by cytosolic phospholipase A2 is involved in the antiapoptotic effect of FK506 and cyclosporin a on astrocytes exposed to simulated ischemia in vitro. |
| Q34362275 | Lipidomic assessment of plasma and placenta of women with early-onset preeclampsia. |
| Q48399636 | MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy |
| Q34039264 | Manipulation of polyketide biosynthesis for new drug discovery. |
| Q34657654 | Models of repair mechanisms for future treatment modalities of Parkinson's disease. |
| Q33772181 | Molecular Dissection of Cyclosporin A's Neuroprotective Effect Reveals Potential Therapeutics for Ischemic Brain Injury |
| Q40534149 | Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells |
| Q35748218 | Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses. |
| Q24685127 | Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton |
| Q41659803 | Neural roles of immunophilins and their ligands |
| Q34731427 | Neural transplantation for treatment of Parkinson's disease. |
| Q36422300 | Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats |
| Q44142404 | Neuroprotective actions of FK506 and cyclosporin A on motor neuron survival following neonatal axotomy |
| Q26747508 | Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives |
| Q80059259 | Neuroprotective and antiretroviral effects of the immunophilin ligand GPI 1046 |
| Q43779453 | Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: therapeutic time window for FK506 in transient focal ischemia |
| Q44703026 | Neuroprotective effects of FK-506, L-carnitine and azathioprine on spinal cord ischemia-reperfusion injury. |
| Q39753504 | Neuroprotective effects of Tacrolimus (FK-506) and Cyclosporin (CsA) in oxidative injury |
| Q35794547 | Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection |
| Q37506492 | Pathogenesis-targeted, disease-modifying therapies in Parkinson disease |
| Q48406783 | Peptidyl-prolyl-cis/trans-isomerase activity may be necessary for memory formation. |
| Q34126600 | Peripheral nerve and neuromuscular allotransplantation: current status |
| Q53429895 | Pin1 mediates Aβ42-induced dendritic spine loss. |
| Q48091798 | Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia |
| Q36014895 | Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells |
| Q48298706 | Prostaglandin E2 stimulates amyloid precursor protein gene expression: inhibition by immunosuppressants |
| Q74305641 | Proteomic analysis of proteins in PC12 cells before and after treatment with nerve growth factor: increased levels of a 43-kDa chromogranin B-derived fragment during neuronal differentiation |
| Q28286510 | Rapalogs and mTOR inhibitors as anti-aging therapeutics |
| Q73964528 | Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca(2+) signaling mechanism in rat hippocampal CA1 neurons |
| Q34096079 | Rapamycin promotes Schwann cell migration and nerve growth factor secretion. |
| Q37514713 | Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease |
| Q73964524 | Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression |
| Q35108317 | Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes |
| Q36025501 | Reinnervation of the tibialis anterior following sciatic nerve crush injury: a confocal microscopic study in transgenic mice |
| Q73551300 | Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity |
| Q43786596 | Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins |
| Q31885807 | Serum withdrawal causes apoptosis in SHSY 5Y cells. |
| Q40642190 | Single HSV-amplicon vector mediates drug-induced gene expression via dimerizer system. |
| Q30876845 | Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands |
| Q27626637 | Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics |
| Q35781266 | Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury |
| Q44614215 | Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands |
| Q48087966 | Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice |
| Q27002488 | Targeting glutamate uptake to treat alcohol use disorders |
| Q37302453 | Targets for neuroprotection in Parkinson's disease |
| Q41817669 | The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility |
| Q47128799 | The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats |
| Q37220915 | The effects of cold preservation and subimmunosuppressive doses of FK506 on axonal regeneration in murine peripheral nerve isografts |
| Q73437043 | The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle |
| Q43823404 | The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons |
| Q34814876 | The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development |
| Q43901301 | The neuroimmunophilin GPI-1046 partially protects against 3-acetylpyridine toxicity in the rat. |
| Q24299896 | The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability |
| Q43512589 | The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats |
| Q33589586 | Treatment modality affects allograft-derived Schwann cell phenotype and myelinating capacity |
| Q30704138 | Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors |
| Q22009168 | muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo |
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