Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination

scientific article (publication date: 6 April 2016)

Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4486-15.2016
P3181OpenCitations bibliographic resource ID3186785
P932PMC publication ID6705512
P698PubMed publication ID27053198
P5875ResearchGate publication ID299800657

P50authorDietmar FischerQ59619107
P2093author name stringAnastasia Andreadaki
Annemarie Heskamp
Heike Diekmann
Marco Leibinger
Philipp Gobrecht
P2860cites workGSK-3 Inhibitors: Preclinical and Clinical Focus on CNSQ21129334
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysisQ24529125
Growing the growth cone: remodeling the cytoskeleton to promote axon regenerationQ26829489
Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithiumQ28269508
Role of phosphorylated MAPlB in neuritogenesisQ28286506
The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regenerationQ28572574
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APCQ28586090
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules.Q30499138
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.Q30597608
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionQ31462537
Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.Q33647021
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.Q34505685
Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.Q34556749
Accelerating axonal growth promotes motor recovery after peripheral nerve injury in miceQ35572510
Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous systemQ35575880
Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon RegenerationQ35860868
SCG10 is a JNK target in the axonal degeneration pathway.Q36504487
Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?Q36577340
GSK3 signalling in neural developmentQ37774552
Facilitating axon regeneration in the injured CNS by microtubules stabilization.Q37941706
Glycogen synthase kinase 3 beta (GSK3β) at the tip of neuronal development and regenerationQ38155462
Advances in peripheral nerve regenerationQ38161788
Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons.Q38330149
GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubulesQ38617811
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination.Q40036486
The GSK3-MAP1B pathway controls neurite branching and microtubule dynamicsQ40101847
Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.Q40175734
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation eventQ40624453
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylationQ40795858
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.Q42141352
Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.Q43102409
Role of GSK3 in peripheral nerve regeneration.Q43154342
Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons.Q44044468
Sustained GSK3 activity markedly facilitates nerve regeneration.Q44773089
Localization of differentially phosphorylated isoforms of microtubule-associated protein 1B in cultured rat hippocampal neuronsQ48096312
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.Q50668696
Pathway sampling by regenerating peripheral axons.Q50773806
Inhibition of glycogen synthase kinase 3beta in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones.Q52101333
Glycogen synthase kinase 3beta phosphorylation of microtubule-associated protein 1B regulates the stability of microtubules in growth cones.Q52174232
A new approach to assess function after sciatic nerve lesion in the mouse - adaptation of the sciatic static index.Q53505571
Neuroprotective and neuroregenerative effects of low-intensity aerobic exercise on sciatic nerve crush injury in miceQ58110767
Pre-existing pathways promote precise projection patternsQ74598597
Parthenolide inhibits tubulin carboxypeptidase activityQ80099860
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acidsQ83215356
Taxol facilitates axon regeneration in the mature CNSQ83421222
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectmicrotubuleQ189933
P304page(s)3890-3902
P577publication date2016-04-06
P1433published inJournal of NeuroscienceQ1709864
P1476titlePromotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination
P478volume36

Reverse relations

cites work (P2860)
Q38718341Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.
Q103803773Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
Q91905595Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury
Q92826363Effects of siRNA-Mediated Knockdown of GSK3β on Retinal Ganglion Cell Survival and Neurite/Axon Growth
Q48333958Identity of the Purkinje cell cytoplasmic antibody type 2 autoantibody antigen is finally revealed
Q38984991Microtubule Destabilization Paves the Way to Parkinson's Disease.
Q41576648Microtubules in health and degenerative disease of the nervous system
Q92572897Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis
Q58153852Neuronal Intrinsic Regenerative Capacity: The Impact of Microtubule Organization and Axonal Transport
Q58779669Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration
Q41767071Nociceptive DRG neurons express muscle lim protein upon axonal injury
Q41852681Parthenolide: a novel pharmacological approach to promote nerve regeneration.
Q93135753Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity
Q92034771Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
Q93001111Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex
Q57826410Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway
Q64069767The Application of Omics Technologies to Study Axon Regeneration and CNS Repair
Q92465951The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?
Q104482079Tubulin post-translational modifications control neuronal development and functions
Q47394007Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

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