| scholarly article | Q13442814 |
| P2093 | author name string | Rubinfeld B | |
| Munemitsu S | |||
| Polakis P | |||
| Albert I | |||
| Souza B | |||
| P2860 | cites work | Identification of deletion mutations and three new genes at the familial polyposis locus | Q24294229 |
| Association of the APC gene product with beta-catenin | Q24322359 | ||
| Cell binding function of E-cadherin is regulated by the cytoplasmic domain | Q24564118 | ||
| The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species | Q24567493 | ||
| A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin | Q28252615 | ||
| Association of the APC tumor suppressor protein with catenins | Q28257313 | ||
| APC mutations occur early during colorectal tumorigenesis | Q28274764 | ||
| Identification of FAP locus genes from chromosome 5q21 | Q28300247 | ||
| Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients | Q28300256 | ||
| Identification and characterization of the familial adenomatous polyposis coli gene | Q29620382 | ||
| The APC gene product in normal and tumor cells | Q36203064 | ||
| Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin | Q36233814 | ||
| Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia | Q36383336 | ||
| Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion | Q36534670 | ||
| ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias | Q36565533 | ||
| Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients | Q37010270 | ||
| The role of the adenomatous polyposis coli (APC) gene in human cancers. | Q40715324 | ||
| Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice | Q41400379 | ||
| The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. | Q41454747 | ||
| Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. | Q45952342 | ||
| wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. | Q52543307 | ||
| Cancer, catenins, and cuticle pattern: a complex connection. | Q52544344 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | polyposis | Q2103081 |
| P304 | page(s) | 3046-50 | |
| P577 | publication date | 1995-03-28 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein | |
| P478 | volume | 92 |
| Q35908633 | A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo |
| Q90261330 | A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins |
| Q36295368 | A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin |
| Q36326068 | A cell-free assay system for beta-catenin signaling that recapitulates direct inductive events in the early xenopus laevis embryo |
| Q62977766 | A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor |
| Q30424003 | A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression |
| Q40131969 | A microtiter assay for quantifying protein-protein interactions associated with cell-cell adhesion |
| Q51894522 | A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner. |
| Q52574297 | A new Drosophila APC homologue associated with adhesive zones of epithelial cells. |
| Q39621035 | A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene |
| Q54441309 | A novel frameshift mutation in the APC gene at exon 15 in familial adenomatous polyposis (FAP) with desmoid tumour. |
| Q24324809 | A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals |
| Q47826110 | A positive role for the PP2A catalytic subunit in Wnt signal transduction. |
| Q34016436 | A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition |
| Q34246978 | A possible role for the WNT-1 pathway in oral carcinogenesis. |
| Q38008209 | A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development |
| Q24806539 | A simple method for statistical analysis of intensity differences in microarray-derived gene expression data |
| Q56886419 | A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties |
| Q33627310 | A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription |
| Q42917420 | A yeast model system for functional analysis of beta-catenin signaling |
| Q34720522 | A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. |
| Q39365999 | ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines |
| Q73840549 | APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysis |
| Q58093304 | APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes |
| Q74099686 | APC genotype, polyp number, and surgical options in familial adenomatous polyposis |
| Q54736420 | APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations. |
| Q35745470 | APC mutations in sporadic medulloblastomas |
| Q40819100 | APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export |
| Q57693627 | APC/CTNNB1 (?-catenin) pathway alterations in human prostate cancers |
| Q33745117 | APC: the plot thickens |
| Q38252534 | AXIN1 and AXIN2 variants in gastrointestinal cancers |
| Q44653354 | Aberrant Intranuclear Localization of Biotin, Biotin-binding Enzymes, and β-Catenin in Pregnancy-Related Endometrium and Morule-Associated Neoplastic Lesions |
| Q42019066 | Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer |
| Q53403183 | Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas. |
| Q35913641 | Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions |
| Q35658457 | Aberrant nuclear localization of beta-catenin without genetic alterations in beta-catenin or Axin genes in esophageal cancer |
| Q36397234 | Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China |
| Q42015210 | Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines |
| Q54601729 | Absence of beta-catenin alteration in hepatic tumors induced by p-nitroanisole in Crj:BDF1 mice. |
| Q33399095 | Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells |
| Q52541567 | Actin-dependent membrane association of a Drosophila epithelial APC protein and its effect on junctional Armadillo. |
| Q38293691 | Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes |
| Q40901818 | Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells |
| Q35763147 | Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity |
| Q28594585 | Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. |
| Q24290419 | Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm |
| Q30434502 | Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion |
| Q36259404 | Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis |
| Q61809717 | Advances in Identification of Susceptibility Gene Defects of Hereditary Colorectal Cancer |
| Q46725854 | Altered distribution of beta-catenin, and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers |
| Q38162230 | An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development |
| Q36237334 | An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling |
| Q35594366 | An insight into the genetic pathway of adenocarcinoma of the small intestine |
| Q34430311 | Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. |
| Q37182324 | Analysis of masked mutations in familial adenomatous polyposis |
| Q36477008 | Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population |
| Q80403549 | Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli |
| Q38529553 | Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus |
| Q27009170 | Animal models of colorectal cancer |
| Q42837423 | Antagonism of cell adhesion by an alpha-catenin mutant, and of the Wnt-signaling pathway by alpha-catenin in Xenopus embryos. |
| Q44071251 | Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin |
| Q28511030 | Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development |
| Q36376454 | Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells |
| Q28587675 | Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene |
| Q41600949 | Armadillo and dTCF: a marriage made in the nucleus |
| Q61136153 | Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4 |
| Q52604216 | Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? |
| Q34390505 | Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations |
| Q24534442 | Attenuated APC alleles produce functional protein from internal translation initiation |
| Q71131035 | Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein |
| Q28567628 | Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos |
| Q40972375 | Axin prevents Wnt-3a-induced accumulation of beta-catenin |
| Q41036974 | Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin |
| Q28211035 | Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon |
| Q55261056 | Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma. |
| Q28296898 | Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours |
| Q55475305 | Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors. |
| Q73009038 | Beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas |
| Q35788005 | Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection |
| Q36586200 | Beta-catenin mutations in cell lines established from human colorectal cancers |
| Q30436381 | Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling |
| Q27860717 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells |
| Q30478335 | Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis |
| Q34165885 | Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow? |
| Q41732761 | Beta-catenin: a key mediator of Wnt signaling |
| Q37077823 | Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells |
| Q28611046 | Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein |
| Q33828912 | Biochemical interactions in the wnt pathway |
| Q28506899 | Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis |
| Q33892439 | Brachyury is a target gene of the Wnt/beta-catenin signaling pathway |
| Q35143428 | Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells |
| Q37054060 | CBP Activity Mediates Effects of the Histone Deacetylase Inhibitor Butyrate on WNT Activity and Apoptosis in Colon Cancer Cells |
| Q40928326 | CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling |
| Q26799062 | CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer |
| Q35224464 | Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation |
| Q54516140 | Cadherins, catenins and APC in pleural malignant mesothelioma |
| Q34442292 | Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. |
| Q29617743 | Cancer chemoprevention with dietary phytochemicals |
| Q35156255 | Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. |
| Q37405722 | Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells |
| Q44049470 | Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes |
| Q41520638 | Carcinogenesis: A balance between β-catenin and APC |
| Q29617494 | Caught up in a Wnt storm: Wnt signaling in cancer |
| Q28568803 | Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity |
| Q34498089 | Cell adhesion molecules and adhesion abnormalities in prostate cancer. |
| Q43844053 | Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate |
| Q34026636 | Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair |
| Q77803739 | Cellular mechanisms of wingless/Wnt signal transduction |
| Q33902908 | Chemoprevention for colorectal cancer. |
| Q53295200 | Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. |
| Q57174446 | Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1 |
| Q36882797 | Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases |
| Q40828841 | Clinical models of chemoprevention for colon cancer |
| Q74826182 | Coexpression of cyclin A and beta-catenin and survival in breast cancer patients |
| Q34047563 | Colorectal cancer: how does it start? How does it metastasize? |
| Q34103406 | Communication between the cell membrane and the nucleus: role of protein compartmentalization |
| Q40867073 | Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin. |
| Q39766205 | Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients |
| Q33677198 | Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene |
| Q42679605 | Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway |
| Q38968012 | CpG methylation of APC promoter 1A in sporadic and familial breast cancer patients |
| Q36150872 | Cripto as a target for cancer immunotherapy |
| Q37688635 | Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway |
| Q34349607 | Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation |
| Q24301888 | Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function |
| Q47655296 | Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma |
| Q40568061 | Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway |
| Q43606518 | Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma |
| Q35754476 | Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary carcinomas |
| Q40979606 | Cytoskeletal reorganization by soluble Wnt-3a protein signalling |
| Q36382856 | Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells |
| Q37259094 | Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice |
| Q35011212 | Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling |
| Q74456055 | Decreased HER-2 tyrosine kinase expression in rectal mucosa of FAP patients following low-dose sulindac chemoprevention |
| Q37233656 | Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer |
| Q34168202 | Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development |
| Q36561208 | Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein |
| Q39681519 | Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons |
| Q35810766 | Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo |
| Q36945067 | Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells |
| Q36193805 | Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor. |
| Q28182070 | Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein |
| Q37484830 | Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas |
| Q38325310 | Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. |
| Q28143992 | Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system |
| Q22254145 | Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin |
| Q77565725 | Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer |
| Q24683009 | Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin |
| Q52536918 | Disruption of E-cadherin-mediated cell adhesion systems in gastric cancers in young patients. |
| Q35788458 | Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p |
| Q46593430 | Distribution of cell membrane-associated proteins along the human nephron |
| Q64062101 | Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers |
| Q34324973 | Domain landscapes of somatic mutations in cancer |
| Q24682053 | Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization |
| Q38945099 | Down regulated expression of Claudin-1 and Claudin-5 and up regulation of β-catenin: association with human glioma progression |
| Q39528451 | Down-regulation of beta-catenin by activated p53. |
| Q52538423 | Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. |
| Q54781478 | Downregulation of E-cadherin and its undercoat proteins in pituitary growth hormone cell adenomas with prominent fibrous bodies. |
| Q24319688 | Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta |
| Q28112236 | Drosophila apc regulates delamination of invasive epithelial clusters |
| Q38012254 | Drugging Wnt signalling in cancer |
| Q52687776 | Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. |
| Q28504838 | Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures |
| Q36266874 | Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis |
| Q37783963 | Dysplastic lesions in ulcerative colitis: Changing paradigms |
| Q34321680 | E-cadherin complex and its abnormalities in human breast cancer |
| Q22011153 | EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue |
| Q37552436 | EGFR(s) in aging and carcinogenesis of the gastrointestinal tract. |
| Q47218854 | Early colorectal carcinomas: CD10 expression, mucin phenotype and submucosal invasion |
| Q35754153 | Early gastric cancer development in a familial adenomatous polyposis patient |
| Q34920236 | Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors |
| Q28199885 | Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A |
| Q36255369 | Effects of forced expression of an NH2-terminal truncated beta-Catenin on mouse intestinal epithelial homeostasis |
| Q28220621 | Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin |
| Q24547385 | Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway |
| Q35097385 | Enhanced stem cell survival in familial adenomatous polyposis |
| Q31120854 | Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model |
| Q53667058 | Epithelial proliferation induces novel changes in APC expression. |
| Q36689662 | Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery |
| Q34589775 | Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53 |
| Q28588225 | Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice |
| Q24537259 | Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome |
| Q98578894 | Evolutionary genomics of mammalian lung cancer genes reveals signatures of positive selection in APC, RB1 and TP53 |
| Q33891005 | Excess beta-catenin promotes accumulation of transcriptionally active p53. |
| Q40933661 | Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest |
| Q47653064 | Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups |
| Q36310657 | Expression of Cyclin D1 Is Associated with β-Catenin Expression and Correlates with Good Prognosis in Colorectal Adenocarcinoma |
| Q41055625 | Expression of E-cadherin, alpha-catenin and beta-catenin in normal ovarian surface epithelium and epithelial ovarian cancers |
| Q42049422 | Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps. |
| Q55358655 | Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers. |
| Q50666071 | Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development. |
| Q35323930 | Expression of polarity genes in human cancer |
| Q73820419 | Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours |
| Q36641429 | Extensive molecular screening for hereditary non-polyposis colorectal cancer |
| Q38678857 | Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model |
| Q24321511 | FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development |
| Q24312985 | Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells |
| Q30477543 | Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells |
| Q34021254 | Fibro-osseous lesions of the craniofacial bones: β-catenin immunohistochemical analysis and CTNNB1 and APC mutation analysis |
| Q55049539 | Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. |
| Q37356829 | Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium |
| Q73271635 | Frequent activation of the beta-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instability |
| Q43825969 | Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability |
| Q55019423 | Frequent beta-catenin abnormalities in bone and soft-tissue tumors. |
| Q42856513 | Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas |
| Q34788226 | Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. |
| Q28286884 | Functional interaction of beta-catenin with the transcription factor LEF-1 |
| Q47215094 | Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting |
| Q24309150 | GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis |
| Q34809015 | GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos |
| Q22253256 | GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin |
| Q34460648 | Gene mutation as a target for early detection in cancer diagnosis. |
| Q35594693 | Genetic and clinical characterisation of familial adenomatous polyposis: a population based study |
| Q34478047 | Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells |
| Q28472494 | Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo |
| Q33711610 | Genetic pathways in colorectal and other cancers |
| Q57337198 | Genetic pathways in colorectal and other cancers |
| Q34810958 | Genetic profiling of colon cancer |
| Q73592556 | Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis |
| Q33939068 | Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families |
| Q50336867 | Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin |
| Q40848863 | Growth control mechanisms in normal and transformed intestinal cells |
| Q40930487 | H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. |
| Q24319786 | HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing |
| Q47965199 | HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin |
| Q42185661 | HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling. |
| Q58377934 | HPV16 E6 augments Wnt signaling in an E6AP-dependent manner |
| Q36596124 | HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. |
| Q44706836 | Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. |
| Q40987305 | Hepatocyte growth factor and Madin-Darby canine kidney cells: in vitro models of epithelial cell movement and morphogenesis |
| Q24643761 | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men |
| Q64266427 | Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip |
| Q37585442 | Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning |
| Q92670011 | Hypothesis: Retinoblastoma protein inactivation mediates effects of histone deacetylase inhibitor-induced Wnt hyperactivation in colorectal cancer cells |
| Q30408026 | Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells |
| Q28209157 | IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin |
| Q24320344 | Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family |
| Q22008756 | Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor |
| Q28295415 | Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain |
| Q24311976 | Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF |
| Q24317602 | Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome |
| Q48270277 | Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display |
| Q44249209 | Identification of four distinct pools of catenins in mammalian cells and transformation-dependent changes in catenin distributions among these pools |
| Q53387673 | Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. |
| Q28216665 | Identification of the LIM protein FHL2 as a coactivator of beta-catenin |
| Q51289913 | Immunohistochemistry, histopathology and infrared spectral histopathology of colon cancer tissue sections. |
| Q52979434 | Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling. |
| Q42160195 | Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes |
| Q34142593 | Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis |
| Q42082840 | Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). |
| Q36139562 | Increased nuclear β-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia |
| Q41043037 | Induction of mutual stabilization and retardation of tumor growth by coexpression of plakoglobin and E-cadherin in mouse skin spindle carcinoma cells |
| Q24551003 | Inhibition of Tcf3 binding by I-mfa domain proteins |
| Q24602885 | Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein |
| Q33582157 | Inhibition of beta-catenin-mediated transactivation by cadherin derivatives |
| Q48337696 | Inhibition of glycogen synthase kinase 3beta activity regulates proliferation of cultured cerebellar granule cells |
| Q35382945 | Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin |
| Q35126460 | Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer |
| Q28640539 | Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification |
| Q24542536 | Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release |
| Q24522854 | Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin |
| Q37698281 | Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling |
| Q35980185 | Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells |
| Q73603290 | Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer |
| Q84987081 | Is there a relationship between familial adenomatous polyposis and focal nodular hyperplasia? |
| Q36885199 | Isolation and characterization of chicken beta-catenin |
| Q40870720 | Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway |
| Q34148003 | Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas |
| Q57833199 | Judging a Protein by More Than Its Name: GSK-3 |
| Q33710603 | Keeping a close eye on Wnt-1/wg signaling in Xenopus |
| Q35131658 | LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin |
| Q36316600 | Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation |
| Q28131788 | Lessons from hereditary colorectal cancer |
| Q28215632 | Linking beta-catenin to androgen-signaling pathway |
| Q29619810 | Linking colorectal cancer to Wnt signaling |
| Q61796307 | Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer |
| Q24685680 | Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon |
| Q34803102 | Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling |
| Q77932389 | Loss of membranous expression of beta-catenin is associated with tumor progression in cutaneous melanoma and rarely caused by exon 3 mutations |
| Q39248886 | Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. |
| Q38289658 | Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin. Regulation by histone deacetylase 1. |
| Q64245050 | MEK Inhibition Induces Canonical WNT Signaling through YAP in Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition |
| Q38037988 | Major signaling pathways in intestinal stem cells |
| Q26774414 | Mass Spectrometry-Based N-Glycomics of Colorectal Cancer |
| Q50974518 | Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics. |
| Q33814311 | Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways |
| Q37921173 | Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment |
| Q36917152 | Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling |
| Q21245770 | Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? |
| Q89341533 | MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer |
| Q24683887 | Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs |
| Q35004421 | Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells |
| Q28285532 | Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells |
| Q37609953 | Modular Cre/lox system and genetic therapeutics for colorectal cancer |
| Q36061114 | Modulation of Wnt/β-catenin signaling pathway by bioactive food components |
| Q40585576 | Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. |
| Q33775965 | Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin |
| Q41037621 | Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing |
| Q35571030 | Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition |
| Q53307075 | Molecular aspects in the diagnosis of gastric cancer. |
| Q34680639 | Molecular causes of colon cancer |
| Q24535907 | Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex |
| Q33368199 | Molecular pathogenesis of colorectal cancer |
| Q54753099 | Molecular pathology of atypical polypoid adenomyoma of the uterus |
| Q39387545 | Molecular regulation and pharmacological targeting of the β-catenin destruction complex |
| Q36698737 | Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury |
| Q34190195 | Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? |
| Q49919956 | Multiple oncogenic roles of nuclear beta-catenin. |
| Q28371978 | Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis |
| Q54985905 | Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas. |
| Q51806465 | Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma. |
| Q100958900 | Mutations and mechanisms of WNT pathway tumour suppressors in cancer |
| Q73117116 | Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas |
| Q36115338 | Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours. |
| Q36258529 | NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion |
| Q39446786 | Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression |
| Q42453746 | Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo |
| Q36382681 | Next-generation sequencing-based molecular characterization of primary urinary bladder adenocarcinoma |
| Q33511677 | Novel association of APC with intermediate filaments identified using a new versatile APC antibody |
| Q74788528 | Novel germline APC variants in patients with multiple adenomas |
| Q54327637 | Novel mutations of the APC gene and genetic consequences of splicing mutations in the Czech FAP families. |
| Q62937876 | Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients |
| Q28078976 | Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) |
| Q28642503 | Nuclear APC |
| Q36534593 | Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction |
| Q54495616 | Nuclear accumulation of beta-catenin occurs commonly in the epithelial cells of juvenile polyps. |
| Q24319918 | Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation |
| Q36075807 | Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. |
| Q73503222 | Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells |
| Q36623813 | Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma |
| Q43597909 | Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor |
| Q39735654 | Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription |
| Q47145929 | Nuclear expression of claudin-3 in human colorectal adenocarcinoma cell lines and tissues |
| Q28144683 | Nuclear translocation of beta-catenin in colorectal cancer |
| Q42796363 | Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover |
| Q36210844 | Nucleosome remodeler SNF2L suppresses cell proliferation and migration and attenuates Wnt signaling |
| Q35154448 | OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer |
| Q37438495 | Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish |
| Q60910555 | Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer |
| Q82642031 | Overexpression of PTGIS could predict liver metastasis and is correlated with poor prognosis in colon cancer patients |
| Q41130183 | PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling |
| Q28343682 | PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs |
| Q40547011 | Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway |
| Q34327461 | Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells |
| Q28609057 | Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability |
| Q54559631 | Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. |
| Q24291638 | Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC |
| Q97568858 | Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells |
| Q36328372 | Plakoglobin suppresses epithelial proliferation and hair growth in vivo |
| Q34382988 | Polo-like kinases and oncogenesis |
| Q73270781 | Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) |
| Q77378689 | Progesterone regulates beta-catenin mRNA levels in human endometrial stromal cells in vitro |
| Q33926592 | Prognostic impact of TAZ and β-catenin expression in adenocarcinoma of the esophagogastric junction |
| Q43694398 | Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice |
| Q37290958 | Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer |
| Q57479451 | Protein Degradation and the Pathologic Basis of Disease |
| Q24619400 | Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells |
| Q33621574 | Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry |
| Q36929407 | Recent progress in mouse models for tumor suppressor genes and its implications in human cancer |
| Q39966655 | Recruitment of adenomatous polyposis coli and beta-catenin to axin-puncta |
| Q64095854 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review |
| Q41065810 | Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines |
| Q42206599 | Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation. |
| Q41896173 | Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer |
| Q35998575 | Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. |
| Q47072126 | Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development |
| Q28214709 | Regulation of beta-catenin function by the IkappaB kinases |
| Q36275000 | Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system |
| Q77582000 | Regulation of chondrocyte differentiation and maturation |
| Q33869282 | Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development |
| Q36517050 | Repair and regeneration: opportunities for carcinogenesis from tissue stem cells |
| Q36217192 | Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex |
| Q34657359 | Review article: Pathogenesis of sporadic and familial gastric cancer--implications for clinical management and cancer prevention |
| Q74643959 | Screening for mutations of the APC gene in 66 Italian familial adenomatous polyposis patients: evidence for phenotypic differences in cases with and without identified mutation |
| Q24683255 | Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion |
| Q34428701 | Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex |
| Q47849781 | Sequence-based design of a peptide probe for the APC tumor suppressor protein |
| Q24291288 | Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein |
| Q24530639 | Signal transduction by the Wnt family of ligands |
| Q38362658 | Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin |
| Q35788942 | Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations |
| Q28507875 | Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity |
| Q40795419 | Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors |
| Q34067016 | Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas |
| Q35747787 | Sporadic fundic gland polyps with epithelial dysplasia : evidence for preferential targeting for mutations in the adenomatous polyposis coli gene |
| Q24685851 | Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene |
| Q24594194 | Structural basis of the Axin-adenomatous polyposis coli interaction |
| Q27675275 | Structure of the Human Discs Large 1 PDZ2– Adenomatous Polyposis Coli Cytoskeletal Polarity Complex: Insight into Peptide Engagement and PDZ Clustering |
| Q41462860 | Studies of neoplasia in the Min mouse |
| Q28344916 | Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane |
| Q41201776 | Sulindac increases the expression of APC mRNA in malignant colonic epithelial cells: an in vitro study |
| Q39573667 | Superficial fibromatoses are genetically distinct from deep fibromatoses |
| Q40651137 | Synergistic Cooperation between the β-Catenin Signaling Pathway and Steroidogenic Factor 1 in the Activation of the Mullerian Inhibiting Substance Type II Receptor |
| Q36333561 | T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant beta-catenin |
| Q33755135 | TCF transcription factors: molecular switches in carcinogenesis |
| Q37150525 | TCF7L2 genetic defect and type 2 diabetes |
| Q47926649 | TCF: transcriptional activator or repressor? |
| Q35004950 | Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas |
| Q34032260 | Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation |
| Q26821978 | Targeting the Wnt pathways for therapies |
| Q27006826 | Targeting the Wnt signaling pathways in pulmonary arterial hypertension |
| Q37082666 | Taurocholic acid metabolism by gut microbes and colon cancer |
| Q37190358 | Temporal modulation of β-catenin signaling by multicellular aggregation kinetics impacts embryonic stem cell cardiomyogenesis |
| Q28242004 | Testing models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signaling |
| Q42478800 | The APC protein binds to A/T rich DNA sequences |
| Q28255263 | The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis |
| Q52582485 | The APC tumour suppressor has a nuclear export function. |
| Q22011189 | The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase |
| Q35190195 | The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. |
| Q28144549 | The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation |
| Q40967633 | The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. |
| Q38304754 | The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors |
| Q37608193 | The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength |
| Q89976293 | The Role of Carcinogenesis-Related Biomarkers in the Wnt Pathway and Their Effects on Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma |
| Q24803778 | The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway |
| Q33328513 | The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth |
| Q40317015 | The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1. |
| Q34192072 | The Wnt signaling pathway and its role in tumor development |
| Q36728844 | The Wnt signaling pathway: aging gracefully as a protectionist? |
| Q39446727 | The Wnt/Wg signal transducer beta-catenin controls fibronectin expression |
| Q36739216 | The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer |
| Q37572181 | The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors |
| Q34094916 | The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. |
| Q33850066 | The adenomatous polyposis coli protein |
| Q36237136 | The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. |
| Q35608989 | The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma |
| Q55228906 | The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells. |
| Q52566182 | The armadillo family of structural proteins. |
| Q28580717 | The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis |
| Q34322339 | The cadherin-catenin superfamily in endocrine tumors |
| Q24298310 | The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway |
| Q27639186 | The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1) |
| Q29615176 | The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway |
| Q24672049 | The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions |
| Q73200819 | The genetics of colorectal cancer |
| Q37172151 | The genomics of colorectal cancer: state of the art. |
| Q24306497 | The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade |
| Q36237926 | The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics |
| Q41671398 | The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue? |
| Q40331160 | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells |
| Q34838428 | The ins and outs of APC and beta-catenin nuclear transport |
| Q33768672 | The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer |
| Q40949632 | The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors |
| Q38231122 | The molecular landscape of pediatric brain tumors in the next-generation sequencing era. |
| Q33540073 | The oncogenic activation of beta-catenin |
| Q38443274 | The role of adherens junctions in the developing neocortex. |
| Q33962788 | The role of cadherin-mediated adhesion in breast cancer |
| Q33759983 | The role of the E-cadherin complex in gastrointestinal cell differentiation. |
| Q34623795 | The subcellular destinations of APC proteins |
| Q36337058 | The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling |
| Q27860803 | The ubiquitin system |
| Q28367002 | The ubiquitin-proteasome pathway and proteasome inhibitors |
| Q37798661 | The various roles of ubiquitin in Wnt pathway regulation. |
| Q28279593 | The β-catenin destruction complex |
| Q27743283 | Three-dimensional structure of the armadillo repeat region of beta-catenin |
| Q41462850 | Towards a unified model of tumor suppression: lessons learned from the human patched gene |
| Q33722761 | Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis |
| Q40822754 | Truncated DCC reduces N-cadherin/catenin expression and calcium-dependent cell adhesion in neuroblastoma cells |
| Q37341673 | Tumor angiogenesis: initiation and targeting - therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinomas - |
| Q41455911 | Tumor recognition by the cellular immune system: new aspects of tumor immunology. |
| Q36364880 | Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation |
| Q73318790 | Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency |
| Q40084609 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis |
| Q37301937 | Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population |
| Q43201962 | Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer |
| Q36266255 | Vital elements of the Wnt-Frizzled signaling pathway in the nervous system |
| Q22008485 | WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors |
| Q24608963 | WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene |
| Q102053996 | WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID |
| Q38168569 | WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology |
| Q24317695 | WNT7a induces E-cadherin in lung cancer cells |
| Q36305544 | Winding through the WNT pathway during cellular development and demise |
| Q34277243 | Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer |
| Q39306017 | Wnt Signaling in Normal and Malignant Stem Cells |
| Q34323825 | Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors |
| Q37342306 | Wnt signaling from development to disease: insights from model systems |
| Q24801811 | Wnt signaling in breast cancer: have we come full circle? |
| Q24337717 | Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex |
| Q40888981 | Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C. |
| Q24653563 | Wnt signaling: the good and the bad |
| Q29619273 | Wnt signalling and its impact on development and cancer |
| Q34589148 | Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes |
| Q33786436 | Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts |
| Q40018737 | Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes |
| Q36370019 | Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription |
| Q35647527 | Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells |
| Q47587176 | Wnt/β‑catenin pathway activation and silencing of the APC gene in HPV‑positive human cervical cancer‑derived cells |
| Q41200960 | Xenopus cadherins: sorting out types and functions in embryogenesis |
| Q41077299 | ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC. |
| Q47616131 | beta-Catenin and p53 analyses of a breast carcinoma tissue microarray. |
| Q45881527 | beta-Catenin expression during vascular development and degeneration of avian mesonephros. |
| Q41590890 | beta-Catenin is a target for extracellular signals controlling cadherin function: the neurocan-GalNAcPTase connection. |
| Q34302259 | beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. |
| Q28640339 | beta-catenin can be transported into the nucleus in a Ran-unassisted manner |
| Q29547589 | beta-catenin is a target for the ubiquitin-proteasome pathway |
| Q28139147 | beta-catenin signaling and cancer |
| Q40443507 | gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. |
| Q34251205 | p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction |
| Q39131067 | β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid |
| Q37191340 | β-Catenin mutation status and outcomes in sporadic desmoid tumors. |
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