Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification

scientific journal article

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.148.4.691
P932PMC publication ID2169372
P698PubMed publication ID10684251
P5875ResearchGate publication ID236240935

P2093author name stringC. Weaver
G. H. Farr
C. Yost
D. Kimelman
D. M. Ferkey
S. B. Pierce
P2860cites workDIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stabilityQ22010042
GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and OncogenesisQ24309150
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assemblyQ24312910
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -cateninQ24313571
A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in XenopusQ24314402
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βQ24319688
Association of the APC gene product with beta-cateninQ24322359
A member of the Frizzled protein family mediating axis induction by Wnt-5AQ24324119
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complexQ24336704
Signal transduction by the Wnt family of ligandsQ24530639
Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomasQ24532079
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.Q24534260
Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotationQ24683274
Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggsQ24683887
Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathwayQ24683939
dishevelled and armadillo act in the wingless signalling pathway in DrosophilaQ28237239
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formationQ28244304
Association of the APC tumor suppressor protein with cateninsQ28257313
Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin levelQ28282155
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cellsQ28504627
Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3βQ28505773
Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus EmbryosQ28567628
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosQ28619032
The dishevelled protein is modified by wingless signaling in DrosophilaQ28644181
Mechanisms of Wnt signaling in developmentQ29547537
β-catenin is a target for the ubiquitin–proteasome pathwayQ29547589
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3Q29614380
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor proteinQ29614383
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fateQ29619008
A new member of the frizzled family from Drosophila functions as a Wingless receptorQ29620189
The adenomatous polyposis coli (APC) tumor suppressorQ30427620
APC: the plot thickensQ33745117
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.Q33986738
A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stageQ34249607
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryosQ34292991
Patterning the Xenopus blastulaQ34442622
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.Q34507567
Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal developmentQ34519186
A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of ArmadilloQ35908633
Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcriptionQ35977699
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signalingQ36235397
Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axisQ36259404
From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in XenopusQ38528779
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryosQ38530571
Signal transduction through beta-catenin and specification of cell fate during embryogenesisQ38530598
A frizzled homolog functions in a vertebrate Wnt signaling pathwayQ38530621
Injected Wnt RNA induces a complete body axis in Xenopus embryosQ38533774
Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from MesodermQ39758271
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans EmbryosQ39758280
Dorsal Determinants in theXenopusEgg Are Firmly Associated with the Vegetal Cortex and Behave like Activators of theWntPathwayQ40878833
The vegetal determinants required for the Spemann organizer move equatorially during the first cell cycleQ40935919
Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.Q40954159
Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-CateninQ41036974
Gut Reaction to Wnt Signaling in WormsQ41588808
Formation and function of Spemann's organizerQ41689393
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activationQ42809920
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing centerQ45071731
Functional conservation of the Wnt signaling pathway revealed by ectopic expression of Drosophila dishevelled in XenopusQ45122812
LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 PromoterQ46178583
The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer.Q46789522
A Drosophila Axin homolog, Daxin, inhibits Wnt signalingQ47071022
Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axinQ47981369
Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrainQ47981542
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.Q48073390
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryosQ48074534
Spatially regulated translation in embryos: asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in XenopusQ52173928
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-cateninQ52187435
Analysis of Dishevelled signalling pathways during Xenopus developmentQ52199252
Components of wingless signalling in DrosophilaQ52543003
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.Q54633263
A transient array of parallel microtubules in frog eggs: potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axisQ68145365
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3Q72164616
Location and behavior of dorsal determinants during first cell cycle in Xenopus eggsQ73023236
Serine Phosphorylation-regulated Ubiquitination and Degradation of β-CateninQ73735409
Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiserQ73797323
POP-1 and Anterior–Posterior Fate Decisions in C. elegans EmbryosQ74150651
Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotationQ83179912
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)691–702
P577publication date2000-02-21
P1433published inJournal of Cell BiologyQ1524550
P1476titleInteraction among GSK-3, GBP, axin, and APC in Xenopus axis specification
P478volume148

Reverse relations

cites work (P2860)
Q40836017A comparative evaluation of beta-catenin and plakoglobin signaling activity
Q24293496Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling
Q40625384Activation of the canonical beta-catenin pathway by histamine
Q47806576Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers
Q24317033Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta
Q28211035Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon
Q28217024Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
Q36429110Beyond cell adhesion: the role of armadillo proteins in the heart
Q28205826Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways
Q35207622Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment
Q28364561Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration
Q37204595Characterization of the interaction between latency-associated nuclear antigen and glycogen synthase kinase 3beta
Q41586966Clinical significance of inactivated glycogen synthase kinase 3β in HPV-associated cervical cancer: Relationship with Wnt/β-catenin pathway activation
Q28114789Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
Q38117099Cortical rotation and messenger RNA localization in Xenopus axis formation
Q24301888Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
Q27629129Crystal structure of a beta-catenin/Tcf complex
Q27633064Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
Q24304097Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes
Q24534352Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage
Q52609085Dissection of the difference between the group I metal ions in inhibiting GSK3β: a computational study
Q35125209Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation
Q24292002Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules
Q52687776Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli
Q54561008Effect of double mutations K214/A–E215/Q of FRATide on GSK3β: insights from molecular dynamics simulation and normal mode analysis
Q33183622Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells
Q50298738FRAT proteins bind GSK3beta
Q42436467FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma
Q34566865FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A.
Q28585212Frat is dispensable for canonical Wnt signaling in mammals
Q33239129Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.
Q34180579Functional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster
Q24624069GSK-3: tricks of the trade for a multi-tasking kinase
Q37140421GSK3 beta N-terminus binding to p53 promotes its acetylation
Q34374129GSK3 takes centre stage more than 20 years after its discovery
Q34026914GSK3, a master switch regulating cell-fate specification and tumorigenesis
Q43790570GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity
Q40441181Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells
Q34979845Glycogen synthase kinase 3/SHAGGY-like kinases in plants: an emerging family with novel functions
Q50336867Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin
Q45306368Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
Q24305168I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
Q36294220Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice
Q35741631Impaired neural development caused by inducible expression of Axin in transgenic mice
Q34503103Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization
Q40460835Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.
Q57833199Judging a Protein by More Than Its Name: GSK-3
Q34684159Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.
Q38325529LZIC regulates neuronal survival during zebrafish development
Q29619810Linking colorectal cancer to Wnt signaling
Q34023082Lithium Suppresses Astrogliogenesis by Neural Stem and Progenitor Cells by Inhibiting STAT3 Pathway Independently of Glycogen Synthase Kinase 3 Beta
Q39523628Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2)
Q28118992Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
Q52609485Mechanism of kinase inactivation and nonbinding of fratide to GSK3β due to K85M mutation: Molecular dynamics simulation and normal mode analysis
Q28115534MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway
Q39076246MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway
Q36510498Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.
Q34180376Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks
Q35110939Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via β-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3β
Q40614760Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-beta-catenin Pathway.
Q36595560Osteocytes, mechanosensing and Wnt signaling
Q56592148P24, a glycogen synthase kinase 3 (GSK 3) inhibitor
Q36659979Peptides targeting protein kinases: strategies and implications
Q33838680Postgenomic technologies targeting the Wnt signaling network
Q34299875Regulation of GSK-3: a cellular multiprocessor
Q36944107Regulation of glycogen synthase kinase 3beta functions by modification of the small ubiquitin-like modifier
Q39669643Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β
Q35071377Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
Q33965278Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression
Q27628766Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway
Q52582485The APC tumour suppressor has a nuclear export function
Q61833127The Arabidopsis thaliana GSK3/Shaggy like kinase AtSK3-2 modulates floral cell expansion
Q50435820The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis
Q34192072The Wnt signaling pathway and its role in tumor development
Q48289815The Xenopus laevis beta TrCP gene: genomic organization, alternative splicing, 5' and 3' region characterization and comparison of its structure with that of human beta TrCP genes
Q24673748The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Q24314421The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT
Q24672469The links between axin and carcinogenesis
Q36731458The maternally localized RNA fatvg is required for cortical rotation and germ cell formation
Q29620489The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
Q24319976The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling
Q28511400The role of Axin2 in calvarial morphogenesis and craniosynostosis
Q38068918The way Wnt works: components and mechanism.
Q44213639Two putative BIN2 substrates are nuclear components of brassinosteroid signaling
Q47069994Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo
Q87600962WITHDRAWN: Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular pathways
Q51722735Wnt impacts growth and differentiation in ex vivo liver development
Q24618567Wnt modulators in the biotech pipeline
Q28566921Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo
Q37109729Wnt/beta-catenin signaling: new (and old) players and new insights
Q47701681XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus
Q47587159Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles.
Q30872403Znrg, a novel gene expressed mainly in the developing notochord of zebrafish
Q28276987beta-catenin destruction complex: insights and questions from a structural perspective

Search more.