A variant associated with nicotine dependence, lung cancer and peripheral arterial disease (scientific article (publication date: 3 April 2008))

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Q34399720	Genetic factors control nicotine self-administration in isogenic adolescent rat strains
Q28601322	Genetic imaging consortium for addiction medicine: From neuroimaging to genes
Q91844065	Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach
Q42968383	Genetic influences on smoking and clinical disease. Understanding behavioral and biological pathways with mediation analysis
Q36949317	Genetic instrumental variable studies of effects of prenatal risk factors
Q36098249	Genetic mapping of canine fear and aggression
Q47427265	Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.
Q47125986	Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
Q33669117	Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization
Q37172778	Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents
Q36972620	Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers
Q36656946	Genetic scores of smoking behaviour in a Chinese population
Q39849131	Genetic self knowledge and the future of epidemiologic confounding
Q54276981	Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer.
Q24606717	Genetic susceptibility to lung cancer and co-morbidities
Q30485478	Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research
Q34398489	Genetic variability in the regulation of gene expression in ten regions of the human brain
Q28264870	Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor
Q64779654	Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease
Q37295691	Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer
Q33678110	Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium
Q35963119	Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction
Q33651055	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer
Q35605227	Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Q36450086	Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight
Q37264547	Genetic variation in the dopamine pathway and smoking cessation
Q47759764	Genetic variation in the exome: Associations with alcohol and tobacco co-use
Q42936469	Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients.
Q34520394	Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
Q27686799	Genetic vulnerability and susceptibility to substance dependence
Q35694433	Genetics and genomics of chronic obstructive pulmonary disease
Q37723880	Genetics and smoking
Q34618397	Genetics of addictions
Q55548230	Genetics of addictions.
Q47106001	Genetics of addictive behavior: the example of nicotine dependence
Q57418861	Genetics of alcohol dependence
Q55102117	Genetics of biologically based psychological differences.
Q34903148	Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies
Q35237159	Genetics of drug dependence
Q37800567	Genetics of lung-cancer susceptibility
Q37127078	Genetics of peripheral artery disease
Q37322709	Genetics of smoking behavior and its consequences: the role of nicotinic acetylcholine receptors
Q38345688	Genetics of smoking behaviour.
Q28740314	Genetics of sputum gene expression in chronic obstructive pulmonary disease
Q45243471	Genetics. Herit-ability
Q33526292	Genome wide association for addiction: replicated results and comparisons of two analytic approaches
Q37163230	Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries.
Q36527546	Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.
Q37149270	Genome-based prediction of common diseases: methodological considerations for future research
Q21092142	Genome-wide and candidate gene association study of cigarette smoking behaviors
Q30437542	Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15
Q36968466	Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers
Q34274219	Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement
Q37254570	Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes
Q34580817	Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement
Q37464290	Genome-wide association scans for secondary traits using case-control samples
Q28658449	Genome-wide association studies and beyond
Q34764203	Genome-wide association studies and cancer
Q37537247	Genome-wide association studies and the genetic dissection of complex traits
Q37339440	Genome-wide association studies for atherosclerotic vascular disease and its risk factors
Q37830176	Genome-wide association studies for detecting cancer susceptibility
Q37833146	Genome-wide association studies for discovery of genes involved in asthma
Q37831225	Genome-wide association studies of alcohol dependence and substance use disorders
Q47900293	Genome-wide association studies of cancer: current insights and future perspectives
Q27012711	Genome-wide association studies of late-onset cardiovascular disease
Q45069141	Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence
Q28383750	Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population
Q34558036	Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese
Q24629653	Genome-wide association study identifies five loci associated with lung function
Q57032352	Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression
Q52316388	Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.
Q28943321	Genome-wide association study of alcohol dependence
Q34193319	Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
Q64124096	Genome-wide association study of familial lung cancer
Q38776984	Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).
Q35283291	Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
Q37711041	Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways
Q91724331	Genome-wide association study of peripheral artery disease in the Million Veteran Program
Q34018979	Genome-wide association study of smoking behaviours among Bangladeshi adults
Q29417072	Genome-wide association study of smoking behaviours in patients with COPD
Q37156043	Genome-wide association study of smoking initiation and current smoking
Q28943514	Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy
Q37446213	Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample
Q24597886	Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Q36001590	Genome-wide meta-analyses of smoking behaviors in African Americans
Q38820997	Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence
Q37058633	Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence
Q34796363	Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk
Q24188234	Genomic analysis to guide choice of treatment for smoking cessation
Q64975021	Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung cancer.
Q33982861	Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence
Q37171910	Genomics of lung cancer.
Q37738347	Genomics of premature atherosclerotic vascular disease.
Q92893734	Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
Q24607290	Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers
Q30453090	Grand challenges and opportunities for molecular psychiatry research: a perspective
Q42416297	Guest editorial. Genes and lung cancer
Q41891669	Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.
Q35614121	Habenular signaling in nicotine reinforcement.
Q33755611	Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.
Q28610804	Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium
Q35119332	Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.
Q36144918	High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice
Q50899812	High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection.
Q47399880	High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study
Q36288148	High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications
Q35905819	Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment
Q38098148	Histamine-2 receptor antagonists and risk of lung cancer in diabetic patients – an exploratory analysis.
Q40407465	How Genetic and Other Biological Factors Interact with Smoking Decisions
Q36023746	How do we safely get people to stop smoking?
Q37900349	How the genetics of lung cancer may overlap with COPD.
Q52316078	Human Genetics of Addiction: New Insights and Future Directions.
Q34137857	Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis
Q36042505	Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes
Q37236484	Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes
Q33775592	Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients
Q30374916	Identification of Deleterious SNPs and Their Effects on Structural Level in CHRNA3 Gene.
Q37107572	Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA.
Q36318066	Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population
Q57677495	Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue
Q36255653	Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia
Q47556321	Identification of shared genetic variants between schizophrenia and lung cancer.
Q58351997	Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Q92164026	Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population
Q37197102	Impact of tobacco smoking and smoking cessation on cardiovascular risk and disease
Q30847502	In search of causal variants: refining disease association signals using cross-population contrasts
Q28741473	In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression
Q34896200	Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
Q36350246	Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
Q36140093	Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls
Q36243132	Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium
Q28743099	Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD
Q47150637	Individual differences in the neuropsychopathology of addiction
Q34076429	Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapy
Q29417049	Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
Q89909093	Inherited lung cancer: a review
Q35967379	Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma
Q39893914	Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment
Q21560811	Inhibition of the nicotinic acetylcholine receptors by cobra venom α-neurotoxins: is there a perspective in lung cancer treatment?
Q40111690	Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.
Q37373901	Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
Q27308788	Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort
Q34232677	Integrative genomics of chronic obstructive pulmonary disease.
Q37688804	Integrin signaling and lung cancer.
Q37129584	Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study
Q43218184	Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer
Q28394515	International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants
Q30850865	International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways
Q34146547	Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence
Q93362132	Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand
Q33866985	Intra-person variation of urinary biomarkers of oxidative stress and inflammation
Q33714840	Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium
Q42277895	Ion channels in hematopoietic and mesenchymal stem cells
Q60182876	Is Schizophrenia a Risk Factor for Breast Cancer?—Evidence From Genetic Data
Q37385793	Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
Q57700847	Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts
Q44906868	Is susceptibility locus for lung cancer in the 15q25 nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 associated with risk of gastric cancer?
Q21183904	Isolated populations and complex disease gene identification
Q34326879	Joint analysis of tightly linked SNPs in screening step of genome-wide association studies leads to increased power
Q37299656	LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer
Q35641707	Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking
Q30408981	Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence
Q36370325	Leveraging genomic data in smoking cessation trials in the era of Precision Medicine: Why and how.
Q34371896	Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial disease
Q33510721	Light and intermittent cigarette smokers: a review (1989-2009).
Q34535065	Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
Q44542473	Long-term smoking behavior patterns predicting self-reported chronic bronchitis
Q99591365	Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression
Q36061600	Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations
Q88310782	Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology
Q35907435	Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium
Q28386853	Lung cancer in never smokers
Q37023811	Lung cancer in never smokers: a call to action
Q34177155	Lung cancer in never smokers: molecular profiles and therapeutic implications
Q45772698	Lung cancer risk and genetic variants in East Asians: a meta-analysis
Q35090585	Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation.
Q83394751	Lung cancer screening
Q38155065	Lung cancer screening: review and performance comparison under different risk scenarios
Q24649980	Lung cancer susceptibility locus at 5p15.33
Q46049056	Lung cancer: New biological insights and recent therapeutic advances
Q24625044	Lung carcinogenesis by tobacco smoke
Q43206615	Lung function and airway diseases
Q38773403	Mapping rare and common causal alleles for complex human diseases
Q45930766	Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.
Q34331434	Mechanistic links between COPD and lung cancer
Q34778144	Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
Q37706552	Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates
Q37967484	Mendelian randomization: application to cardiovascular disease
Q36870245	Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal
Q37553688	Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research
Q24273244	Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Q34286145	Meta-analysis of 15 genome-wide linkage scans of smoking behavior
Q34325669	Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients
Q34451044	Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk
Q64899234	Mining and validating the expression pattern and prognostic value of acetylcholine receptors in non-small cell lung cancer.
Q36547252	Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice
Q33526671	Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder.
Q24610335	Molecular biology of lung cancer: clinical implications
Q37963519	Molecular changes in smoking-related lung cancer
Q37320742	Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects
Q26851972	Molecular mechanisms underlying behaviors related to nicotine addiction
Q33696507	Molecular profile of lung cancer in never smokers
Q37402403	Molecular targets for cancer chemoprevention
Q33841970	Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats
Q64905768	Multi-environment fitness landscapes of a tRNA gene.
Q34268442	Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
Q37219461	Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
Q28290169	Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
Q38819832	Narrative review of genes, environment, and cigarettes
Q37416447	Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs
Q34085848	Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation
Q34012381	Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system
Q37010016	Neuroimaging, genetics and the treatment of nicotine addiction
Q87542501	Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population
Q34637004	Neurophysiology of Nicotine Addiction
Q30393291	New Insights Into Aortic Diseases: A Report From the Third International Meeting on Aortic Diseases (IMAD3)
Q28088290	New Insights Into Tobacco-Induced Vascular Disease: Clinical Ramifications
Q30435949	New insights into the genetics of addiction
Q28111991	New mechanisms and perspectives in nicotine withdrawal
Q35974959	Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes.
Q29028895	Nicotine Enhances Excitability of Medial Habenular Neurons via Facilitation of Neurokinin Signaling
Q24626554	Nicotine addiction
Q24606748	Nicotine and pathological angiogenesis
Q37381294	Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability
Q36037208	Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
Q37357248	Nicotine dependence and genetic variation in the nicotinic receptors
Q41060193	Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain
Q37632080	Nicotine dependence may link the 15q25 locus to lung cancer risk.
Q34849133	Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines
Q37413060	Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.
Q21142724	Nicotine promotes tumor growth and metastasis in mouse models of lung cancer
Q36823218	Nicotine reduction: strategic research plan
Q30491214	Nicotine response genetics in the zebrafish.
Q36030589	Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors
Q28395572	Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers
Q33620835	Nicotine-mediated signals modulate cell death and survival of T lymphocytes
Q47939175	Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor.
Q36851620	Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
Q42931523	Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity
Q34039696	Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
Q34812123	Nicotinic acetylcholine receptor subunits α4 and α5 associated with smoking behaviour and lung cancer are regulated by upstream open reading frames.
Q34206203	Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.
Q36585530	Nicotinic acetylcholine receptor variation and response to smoking cessation therapies
Q38819660	Nicotinic acetylcholine receptors and cancer
Q42010774	Nicotinic acetylcholine receptors mediate lung cancer growth
Q26782271	Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use
Q35966896	Nicotinic receptor contributions to smoking: insights from human studies and animal models
Q37037625	Nicotinic receptor gene variants influence susceptibility to heavy smoking
Q37390152	Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice
Q37590093	Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Q38390054	Non-neuronal cholinergic system in airways and lung cancer susceptibility
Q26740333	Non-small cell lung cancer: current treatment and future advances
Q28278682	Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship
Q37874768	Non-small-cell lung cancer.
Q48193287	Normative theorizing about genetics
Q28390824	Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk
Q47233603	Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer
Q35230314	Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.
Q37789759	Occupational toxicology of asbestos-related malignancies
Q37284551	Older smokers' motivation and attempts to quit smoking: epidemiological insight into the question of lifestyle versus addiction
Q41665474	On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects
Q36786728	One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility
Q38678269	Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies
Q27693327	Oral premalignancy: the roles of early detection and chemoprevention
Q83348668	PTSD is a risk factor for cardiovascular disease: time for increased screening and clinical intervention
Q38619755	Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer
Q35782709	Parental intermittent claudication as risk factor for claudication in adults
Q90628873	Participatory design of a personalized genetic risk tool to promote behavioral health
Q37389526	Pathogenesis of lung cancer signalling pathways: roadmap for therapies
Q30647266	Pathway-based analysis using genome-wide association data from a Korean non-small cell lung cancer study
Q34527740	Pathways to precision medicine in smoking cessation treatments
Q28315283	Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence
Q47864520	Peripheral Arterial Disease Genetics: Progress to Date and Challenges Ahead
Q38956356	Peripheral Artery Disease and Aortic Disease
Q37777012	Peripheral Artery Disease and Genetics: Is There a Cause-and-Effect Relationship?
Q30426617	Peripheral arterial disease in diabetes: is there a role for genetics?
Q33706037	Pharmacogenetics of chronic obstructive pulmonary disease: challenges and opportunities
Q34132214	Pharmacogenetics of nicotine addiction: role of dopamine
Q38345693	Pharmacogenetics of nicotine and associated smoking behaviors
Q35059965	Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment
Q36158678	Pharmacogenomics of platinum-based chemotherapy in NSCLC
Q38909984	Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine
Q35287506	Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001
Q48015634	Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers.
Q33455775	Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
Q24289286	Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study
Q39449490	Pleiotropic Analysis of Lung Cancer and Blood Triglycerides
Q28390545	Pleiotropy in complex traits: challenges and strategies
Q41640368	Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population.
Q40321770	Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
Q47254894	Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer
Q90624293	Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population
Q36596440	Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population
Q36719039	Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls
Q28547248	Positive Selection on Loci Associated with Drug and Alcohol Dependence
Q36039402	Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review.
Q46318735	Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps
Q33520624	Power to detect selective allelic amplification in genome-wide scans of tumor data
Q30432971	Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches
Q64068915	Precision oncology of lung cancer: genetic and genomic differences in Chinese population
Q30636967	Predicting PTSD using the New York Risk Score with genotype data: potential clinical and research opportunities
Q34507724	Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
Q89537251	Predictors of Current DSM-5 PTSD Diagnosis and Symptom Severity Among Deployed Veterans: Significance of Predisposition, Stress Exposure, and Genetics
Q60456061	Predisposing to behaviour?
Q37381539	Prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters: a 40-year prospective study.
Q47200916	Preparing the Way: Exploiting Genomic Medicine to Stop Smoking
Q37266098	Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle.
Q47135096	Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments
Q42928495	Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5.
Q37602287	Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats
Q35792273	Prospects for epigenetic epidemiology
Q34400233	Protection genes in nucleus accumbens shell affect vulnerability to nicotine self-administration across isogenic strains of adolescent rat
Q37036306	Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
Q38399264	Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk
Q37510681	Quantitative assessment of the influence of TP63 gene polymorphisms and lung cancer risk: evidence based on 93,751 subjects
Q54569117	Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk.
Q37398369	RGS17: an emerging therapeutic target for lung and prostate cancers
Q37158296	Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer
Q28943461	Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Q28601375	Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans
Q93271394	Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis
Q35815222	Recent advances in the genetic epidemiology and molecular genetics of substance use disorders
Q35184641	Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior.
Q34374445	Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons
Q34049029	Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives: II. Evidence from a laboratory self-administration assay
Q35202104	Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk
Q30395065	Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
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P6179	Dimensions Publication ID	1000224730
P356	DOI	10.1038/NATURE06846
P3181	OpenCitations bibliographic resource ID	1241751
P932	PMC publication ID	4539558
P698	PubMed publication ID	18385739
P5875	ResearchGate publication ID	5466244

P50	author	Augustine Kong	Q28050134
		Tómas Gudbjartsson	Q94660554
		Katja K H Aben	Q102218306
		Berta Sáez Gutiérrez	Q103710051
		Julius Gudmundsson	Q114530409
		Roberto Pola	Q39362021
		Lambertus Kiemeney	Q40024880
		Thorgeir E. Thorgeirsson	Q47502252
		Gregory T. Jones	Q52564098
		Jon T Bergthorsson	Q55128634
		Gyda Bjornsdottir	Q56450922
		Frank Geller	Q56839812
		Laura Asin	Q57198766
		Halla Skuladottir	Q58470476
		Jeffrey Gulcher	Q66823431
P2093	author name string	Thomas Mueller
		Andres Ingason
		Daniel F Gudbjartsson
		Kristinn P Magnusson
		Thorlakur Jonsson
		Peter F A Mulders
		Jose I Mayordomo
		Simon N Stacey
		Kari Stefansson
		Margret Jakobsdottir
		Patrick Sulem
		Thorunn Rafnar
		Unnur Thorsteinsdottir
		Steinn Jonsson
		Hreinn Stefansson
		Halldor Kolbeinsson
		Jon G Stefansson
		Gudmar Thorleifsson
		Kristleifur Kristjansson
		Larus J Gudmundsson
		Andre M van Rij
		Bengt Lindblad
		Benjamin Dieplinger
		Meinhard Haltmayer
		Anna Wiste
		Ingunn Hansdottir
		Thorarinn Tyrfingsson
		Hogni Oskarsson
		Stefan E Matthiasson
		Dolores Isla
		Anders Gottsäter
		Jona Saemundsdottir
		Helgi J Isaksson
		Andrea Flex
		Femmie de Vegt
		Laura Murillo
		Steinunn Thorlacius
		Andrei Manolescu
		Valgerdur Runarsdottir
		Thorsteinn Blondal
		Maria J Vidal
		Olof Olafsdottir
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P433	issue	7187
P407	language of work or name	English	Q1860
P921	main subject	lung cancer	Q47912
		nicotine	Q12144
		nicotine dependence	Q18553444
P304	page(s)	638-642
P577	publication date	2008-04-01
P1433	published in	Nature	Q180445
P1476	title	A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
P478	volume	452

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

scientific article (publication date: 3 April 2008)

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