The multifunctional nucleolus

scientific article (publication date: July 2007)

The multifunctional nucleolus is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1023910701
P356DOI10.1038/NRM2184
P3181OpenCitations bibliographic resource ID51029
P698PubMed publication ID17519961
P5875ResearchGate publication ID6312704

P50authorAngus LamondQ21165211
Francois-Michel BoisvertQ58899874
P2093author name stringSilvana van Koningsbruggen
Joaquín Navascués
P2860cites workNucleolar proteome dynamicsQ21735921
Dyskerin localizes to the nucleolus and its mislocalization is unlikely to play a role in the pathogenesis of dyskeratosis congenitaQ22010777
A telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
Nuclear structure in normal and Bloom syndrome cellsQ22253976
p53 Modulates the exonuclease activity of Werner syndrome proteinQ24291371
Directed proteomic analysis of the human nucleolusQ24292165
Impaired ribosome biogenesis in Diamond-Blackfan anemiaQ24307762
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functionsQ24317067
Functional proteomic analysis of human nucleolusQ24318249
Nucleolar localization of the Werner syndrome protein in human cellsQ24323083
Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140.Q24540218
Characterization of the nucleolar gene product, treacle, in Treacher Collins syndromeQ24550683
Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNAQ24554419
Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response elementQ24603188
Parathyroid hormone-related protein purified from a human lung cancer cell lineQ24604722
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23Q24629309
Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cellsQ24680202
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolutionQ27621159
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.Q27863917
The SUMO-specific protease SENP5 is required for cell divisionQ27863924
Making ribosomesQ27930690
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complexQ27937157
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related proteinQ28201295
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase IQ28236082
Nucleolin interacts with telomeraseQ28282467
Dynamic association of RNA-editing enzymes with the nucleolusQ28570439
Role of nucleophosmin in embryonic development and tumorigenesisQ28591282
Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells.Q40301544
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.Q40456137
UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery.Q40480663
Signal sequence recognition and protein targeting to the endoplasmic reticulum membraneQ40611469
Subnuclear shuttling of human telomerase induced by transformation and DNA damage.Q40708285
Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylationQ41809177
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosisQ42238919
Identification of a nuclear localization signal and nuclear export signal of the umbraviral long-distance RNA movement protein.Q42625603
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesisQ42720850
Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activityQ42835382
Adeno-associated virus interactions with B23/Nucleophosmin: identification of sub-nucleolar virion regionsQ42911847
Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cellsQ42915416
Involvement of the nucleolus in plant virus systemic infectionQ43715533
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modificationQ44274699
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolusQ44992554
Changes in nucleolar morphology and proteins during infection with the coronavirus infectious bronchitis virusQ45414887
A wiring of the human nucleolus.Q45965974
An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana.Q46026182
A study of the utility of silver nucleolar organizer regions in categorization and prognosis of salivary gland tumors.Q46438448
Evaluation of the nucleolar organizer regions in Alzheimer's disease.Q53271685
Crystal structure of an H/ACA box ribonucleoprotein particle.Q53589609
RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome.Q53624157
The nucleolus: the magician's hat for cell cycle tricksQ56951124
Signaling to p53: breaking the MDM2-p53 circuitQ77430977
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing centerQ79900373
Number and location of nucleoli and presence of apoptotic bodies in diagnostically challenging cases of prostate adenocarcinoma on needle biopsyQ81423054
Small Nucleolar RNAsQ29300155
Protein modification by SUMOQ29547919
The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylationQ29615268
Pre-ribosomes on the road from the nucleolus to the cytoplasmQ29616319
Does the ribosome translate cancer?Q29618775
Deciphering the human nucleolar proteomeQ30050739
Discovery of the nucleolar targeting signalQ30396388
Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells.Q30475934
Localization of signal recognition particle RNA in the nucleolus of mammalian cellsQ32057725
Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functionsQ33564752
Nucleolus: from structure to dynamicsQ33991847
Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.Q34320080
Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs.Q34366130
Functional diversity of protein phosphatase-1, a cellular economizer and reset buttonQ34649261
The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseasesQ34702915
The nucleolus--a gateway to viral infection?Q34732586
The nucleolus: a site of ribonucleoprotein maturationQ35145834
RecQ helicases: suppressors of tumorigenesis and premature aging.Q35152970
MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cellsQ35539712
Bioinformatic analysis of the nucleolusQ35553216
How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-activationQ35700328
Cell and molecular biology of nucleolar assembly and disassemblyQ35909195
The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORsQ36236758
ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAsQ36321153
Cyclin-dependent kinases govern formation and maintenance of the nucleolusQ36324448
In vivo release of mitotic silencing of ribosomal gene transcription does not give rise to precursor ribosomal RNA processingQ36326259
Nucleolar assembly of the rRNA processing machinery in living cellsQ36326406
The dynamics of postmitotic reassembly of the nucleolusQ36328472
Nucleolar dominance: a model for rRNA gene silencingQ36479659
Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell deathQ36553295
Nucleophosmin: a versatile molecule associated with hematological malignancies.Q36597677
Mitotic phosphatases: no longer silent partnersQ36618472
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionationQ36823776
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stressQ40236887
Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer.Q40255839
A nucleolar localizing Rev binding element inhibits HIV replicationQ40277839
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)574-585
P577publication date2007-07-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleThe multifunctional nucleolus
P478volume8

Reverse relations

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Q64096554Increased expression of NAF1 contributes to malignant phenotypes of glioma cells through promoting protein synthesis and associates with poor patient survival
Q34386732Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
Q28589774Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
Q28468631Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Q21090208Initial genomics of the human nucleolus
Q37412753Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response.
Q39415824Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis.
Q93210297Instructed Assembly of Peptides for Intracellular Enzyme Sequestration
Q36232013Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme--phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis
Q64883630Integrating the DNA damage and protein stress responses during cancer development and treatment.
Q64947197Integrative rDNAomics-Importance of the Oldest Repetitive Fraction of the Eukaryote Genome.
Q27930239Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes.
Q96954791Interactions by Disorder - A Matter of Context
Q47142042Intrinsically disordered proteins in the nucleus of human cells
Q24322804Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
Q34529796Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
Q39593296Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress
Q37462625Involvement of the nucleolus in replication of human viruses
Q37800653Involvement of the plant nucleolus in virus and viroid infections: parallels with animal pathosystems.
Q58136316Is one-time carbon monoxide intoxication harmless? Evaluation by argyrophilic nucleolar-organizing regions staining method
Q54389835Is there any relationship between decreased AgNOR protein synthesis and human hair loss?
Q37605627Isotope labeling strategies for NMR studies of RNA
Q34525535Karyotypic diversity in seven Amazonian anurans in the genus Hypsiboas (family Hylidae)
Q90575517Keeping ribosomal DNA intact: a repeating challenge
Q43187753Key labeling technologies to tackle sizeable problems in RNA structural biology
Q40076045Kinetics of the association of dengue virus capsid protein with the granular component of nucleolus
Q28255964LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis
Q90029511LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA
Q34699315Label-free imaging of mammalian cell nucleoli by Raman microspectroscopy
Q39677695Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis
Q33594311Lentiviral protein transduction with genome-modifying HIV-1 integrase-I-PpoI fusion proteins: studies on specificity and cytotoxicity
Q36440102Limited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes
Q35583640Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Q46062708Liquid Phase Transition in the Postsynaptic Density?
Q93163796Liquid-liquid phase separation in artificial cells
Q47070256Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila
Q38947456Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress
Q89965893Looking At the Past and Heading to the Future: Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany
Q37310609Loss of MTG16a (CBFA2T3), a novel rDNA repressor, leads to increased ribogenesis and disruption of breast acinar morphogenesis
Q92642176Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux
Q34683193Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription
Q30856892Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response
Q51082530Loss of the RNA helicase SKIV2L2 impairs mitotic progression and replication-dependent histone mRNA turnover in murine cell lines.
Q37028399Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli
Q36689527Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin
Q42057529Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells
Q41889733MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis.
Q37461058Mapping signals that are important for nuclear and nucleolar localization in MCRS2.
Q98193102Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder
Q34988096MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.
Q39220061Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila
Q48224054Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters.
Q64970252Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.
Q91854786Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level
Q24299575Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis
Q37344528MicroRNAs with a nucleolar location
Q30499682Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited
Q39827551Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro
Q48063977Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells.
Q96134290Molecular cloning, expression, overproduction and characterization of human TRAIP Leucine zipper protein
Q33347753Molecular dissection of the pea shoot apical meristem
Q53250013Monitoring the rate and dynamics of concerted evolution in the ribosomal DNA repeats of Saccharomyces cerevisiae using experimental evolution.
Q58692663Morphological Changes of Mammalian Nucleoli during Spermatogenesis and Their Possible Role in the Chromatoid Body Assembling
Q34046059Morphological Studies of Nucleologenesis in Giardia lamblia
Q26768988Morphology of nuclear transcription
Q57470050Multiple pools of nuclear actin
Q40421409Multiple regions in dengue virus capsid protein contribute to nuclear localization during virus infection
Q36977152Multiscale spatial organization of RNA polymerase in Escherichia coli
Q27329518Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes
Q24643797Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome
Q28507301Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing
Q39399787Myeloma cells contain high levels of inorganic polyphosphate which is associated with nucleolar transcription
Q39824158Myosin Vb localises to nucleoli and associates with the RNA polymerase I transcription complex.
Q28594181N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies
Q39265821NC-mediated nucleolar localization of retroviral gag proteins
Q34013972NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells
Q33705054NOF1 encodes an Arabidopsis protein involved in the control of rRNA expression.
Q93110551NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging
Q24298822NOM1 targets protein phosphatase I to the nucleolus
Q34872544NOPdb: Nucleolar Proteome Database--2008 update
Q28586666Nepro is localized in the nucleolus and essential for preimplantation development in mice
Q34047811Nervous necrosis virus capsid protein exploits nucleolar phosphoprotein Nucleophosmin (B23) function for viral replication
Q35802822Neuroprotective Effect of Bexarotene in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
Q35604821New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein
Q34042969New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases
Q37173760New insights into the role of PML in tumour suppression
Q48274617New insights into the spermatogenesis of the black tiger prawn, Penaeus monodon.
Q58798742Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
Q33980572NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins
Q24306533Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing
Q35195571Nom1 mediates pancreas development by regulating ribosome biogenesis in zebrafish
Q38970119Non-Random Patterns in the Distribution of NOR-Bearing Chromosome Territories in Human Fibroblasts: A Network Model of Interactions
Q57590602Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway
Q47974412Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.
Q47150670Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin
Q37710725Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells
Q24299137Novel nucleolar pathway connecting intracellular energy status with p53 activation
Q37149516Nuclear functions in space and time: gene expression in a dynamic, constrained environment
Q35132575Nuclear physics: quantitative single-cell approaches to nuclear organization and gene expression
Q37133895Nuclear pore complex proteins mark the implantation window in human endometrium
Q39013064Nuclear subcompartments: an overview
Q42390244Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.
Q52841653Nucleation by rRNA Dictates the Precision of Nucleolus Assembly.
Q35915370Nucleolar DEAD-Box RNA Helicase TOGR1 Regulates Thermotolerant Growth as a Pre-rRNA Chaperone in Rice
Q57073168Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling
Q58575140Nucleolar Division in the Promastigote Stage of Parasite: A Nop56 Point of View
Q59131677Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
Q39067763Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin
Q97569214Nucleolar RNA polymerase II drives ribosome biogenesis
Q38743349Nucleolar Reorganization Upon Site-Specific Double-Strand Break Induction
Q91869139Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies
Q92932241Nucleolar Stress: hallmarks, sensing mechanism and diseases
Q34014508Nucleolar accumulation of RNA binding proteins induced by Actinomycin D is functional in Trypanosoma cruzi and Leishmania mexicana but not in T. brucei
Q26821979Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?
Q37855730Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer
Q38722337Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.
Q92257313Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer
Q33354407Nucleolar chromatin organization at different activities of soybean root meristematic cell nucleoli
Q43983188Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells
Q54858673Nucleolar dominance and maternal control of 45S rDNA expression.
Q34031852Nucleolar dominance and ribosomal RNA gene silencing
Q83226906Nucleolar dynamics and interactions with nucleoplasm in living cells
Q59123049Nucleolar exit of RNF8 and BRCA1 in response to DNA damage
Q58761890Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance
Q54976727Nucleolar integrity during interphase supports faithful Cdk1 activation and mitotic entry.
Q39066049Nucleolar localization and circadian regulation of Per2S, a novel splicing variant of the Period 2 gene
Q34146439Nucleolar localization of GLTSCR2/PICT-1 is mediated by multiple unique nucleolar localization sequences
Q33918234Nucleolar localization of RNA binding proteins induced by actinomycin D and heat shock in Trypanosoma cruzi.
Q36954034Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells
Q39726612Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells
Q24657753Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
Q27349004Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1
Q37775931Nucleolar proteomics and viral infection
Q36781105Nucleolar repression facilitates initiation and maintenance of senescence
Q58699976Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription
Q44356144Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21.
Q30487020Nucleolar separation from chromosomes during Aspergillus nidulans mitosis can occur without spindle forces
Q91105584Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines
Q34183329Nucleolar stress with and without p53.
Q58555566Nucleolar stress: is there a reverse version?
Q47347372Nucleolar sub-compartments in motion during rRNA synthesis inhibition: Contraction of nucleolar condensed chromatin and gathering of fibrillar centers are concomitant
Q30495322Nucleolar targeting of the chaperone hsc70 is regulated by stress, cell signaling, and a composite targeting signal which is controlled by autoinhibition
Q37135320Nucleolar targeting: the hub of the matter
Q42179988Nucleolar tethering mediates pairing between the IgH and Myc loci
Q55007528Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.
Q38225814Nucleoli and stress granules: connecting distant relatives.
Q58577976Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?
Q34232542Nucleoli: composition, function, and dynamics.
Q34047444Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair
Q38348043Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.
Q42090068Nucleolin is required for an efficient herpes simplex virus type 1 infection.
Q52872512Nucleologenesis in Trypanosoma cruzi.
Q84297931Nucleolus as an oxidative stress sensor in the yeast Saccharomyces cerevisiae
Q33757972Nucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation.
Q92902499Nucleolus structural integrity during the first meiotic prophase in rat spermatocytes
Q38824781Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways
Q24679693Nucleolus: the fascinating nuclear body
Q36673676Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.
Q36739883Nucleophosmin is a binding partner of nucleostemin in human osteosarcoma cells
Q42126825Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting deubiquitylating enzyme USP36.
Q44521365Nucleoplasmic/nucleolar translocation and identification of a nuclear localization signal (NLS) in Dictyostelium BAF60a/SMARCD1 homologue Snf12.
Q34417328Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.
Q33907013O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins
Q52735849Occurrence of pre-nucleolar bodies and 45S rDNA location on the chromosomes of the ant Mycocepurus goeldii (Forel) (Formicidae, Myrmicinae, Attini).
Q34637812On emerging nuclear order
Q55256293Optimized protocol for combined PALM-dSTORM imaging.
Q35261449Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
Q21184008Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum
Q51866095OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis.
Q36381600Overexpression of ribosomal RNA in cumulus cells of patients with polycystic ovary syndrome
Q35969248P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig.
Q34723518PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop.
Q91810240PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner
Q54119892PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.
Q24336209PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
Q33805360PNAC: a protein nucleolar association classifier.
Q34896634PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence
Q41073169PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin
Q27005780Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
Q39026988Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation.
Q28071484Phase separation in biology; functional organization of a higher order
Q64084736Phase-to-Phase With Nucleoli - Stress Responses, Protein Aggregation and Novel Roles of RNA
Q91775571Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae
Q28554321Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3
Q34076444Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function
Q53305315Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles.
Q59265339Photo-induced uncaging of a specific Re(i) organometallic complex in living cells
Q34553965Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.
Q50538217Pol II-directed short RNAs suppress the nuclear export of mRNA.
Q34126377Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli
Q52673130Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation.
Q37139138Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins
Q36345232Prediction of hydrogen and carbon chemical shifts from RNA using database mining and support vector regression
Q26753190Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
Q30494319Probing adenine rings and backbone linkages using base specific isotope-edited Raman spectroscopy: application to group II intron ribozyme domain V.
Q30651049Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture
Q39642591Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability
Q39600050Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response
Q64926874Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock.
Q37318391Proteomic analysis of bovine nucleolus
Q35562902Proteomic characterization of the nucleolar linker histone H1 interaction network
Q42935025Proteomics analysis of the nucleolus in adenovirus-infected cells
Q47352667Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution.
Q35497627Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.
Q50588513RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63.
Q28080877RNA Regulation by Poly(ADP-Ribose) Polymerases
Q36103176RNA transcription modulates phase transition-driven nuclear body assembly
Q35447494RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency
Q39456968RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance
Q39647526RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits
Q49849409RaRF confers RA resistance by sequestering RAR to the nucleolus and regulating MCL1 in leukemia cells.
Q39434989Rad53 homologue forkhead-associated kinase A (FhkA) and Ca2+-binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium
Q93155690Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10
Q33424086Reconstructing the ubiquitin network: cross-talk with other systems and identification of novel functions
Q99721480Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization
Q34047411Regulation of BLM Nucleolar Localization
Q33673647Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B
Q36890081Regulation of Sli15/INCENP, kinetochore, and Cdc14 phosphatase functions by the ribosome biogenesis protein Utp7
Q24312714Regulation of cyclin D1 RNA stability by SNIP1
Q34047157Regulation of nucleolus assembly by non-coding RNA polymerase II transcripts
Q28241411Regulation of rDNA transcription by proto-oncogene PELP1
Q37394276Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress
Q58295519Relationship between the nucleolar cycle and chromatoid body formation in the spermatogenesis ofPhrynops geoffroanus(Reptilia Testudines)
Q42388503Relationships between rDNA, Nop1 and Sir complex in biotechnologically relevant distillery yeasts.
Q30494332Relocalization of upstream binding factor to viral replication compartments is UL24 independent and follows the onset of herpes simplex virus 1 DNA synthesis
Q89601821Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors
Q35684586Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Q35596269Resistance to maribavir is associated with the exclusion of pUL27 from nucleoli during human cytomegalovirus infection
Q90265148Review of the "X chromosome-nucleolus nexus" hypothesis of autoimmune diseases with an update explaining disruption of the nucleolus
Q45301628Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans
Q33886171Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation
Q90115308Ribosomal Protein L15 is involved in Colon Carcinogenesis
Q91835682Ribosomal RNA fragmentation into short RNAs (rRFs) is modulated in a sex- and population of origin-specific manner
Q38875503Ribosomal RNA gene functioning in avian oogenesis
Q36056785Ribosomal RNA of Hyacinthus orientalis L. female gametophyte cells before and after fertilization
Q39812243Ribosomal protein S7 is both a regulator and a substrate of MDM2
Q24322997Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
Q90975157Ribosomal protein uL3 targets E2F1 and Cyclin D1 in cancer cell response to nucleolar stress
Q47748537Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma
Q64101322Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts
Q46235556Ribosome Biogenesis Modulates Ty1 Copy Number Control in Saccharomyces cerevisiae.
Q47344527Ribosome biogenesis in cancer: new players and therapeutic avenues
Q37760417Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway.
Q36905257Ribosome biogenesis: emerging evidence for a central role in the regulation of skeletal muscle mass.
Q27319572Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans
Q41645126Rice stripe tenuivirus p2 may recruit or manipulate nucleolar functions through an interaction with fibrillarin to promote virus systemic movement.
Q28068265Role of ribosomal protein mutations in tumor development (Review)
Q34045051Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review.
Q50008910SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats.
Q43100862SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner
Q48068045SLOW WALKER2, a NOC1/MAK21 homologue, is essential for coordinated cell cycle progression during female gametophyte development in Arabidopsis
Q39590910SR and SR-related proteins redistribute to segregated fibrillar components of nucleoli in a response to DNA damage
Q36393042SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage
Q37953790SUMO routes ribosome maturation.
Q36564384SUMO: a multifaceted modifier of chromatin structure and function
Q43208614SUV39h-independent association of HP1 beta with fibrillarin-positive nucleolar regions
Q50421526Salt hypersensitive mutant 9, a nucleolar APUM23 protein, is essential for salt sensitivity in association with the ABA signaling pathway in Arabidopsis.
Q64226605Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10-Imp3-Imp4 complex to nucleolus
Q37068550Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein
Q34405478Severe heat shock induces nucleolar accumulation of mRNAs in Trypanosoma cruzi
Q52882567Sharing of mitotic pre-ribosomal particles between daughter cells.
Q35791976Signaling mechanisms in the regulation of renal matrix metabolism in diabetes
Q39438246Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation.
Q90591081Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity
Q47955861SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.
Q30830659Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo
Q38501773Sorting the nuclear proteome
Q37437882Spatial link between nucleoli and expression of the Zac1 gene
Q30565963Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy.
Q37591321Spatial organization of genes as a component of regulated expression
Q38668139Spatiotemporally Controllable Peptide-Based Nanoassembly in Single Living Cells for a Biological Self-Portrait
Q26783721Splicing noncoding RNAs from the inside out
Q50098862Splicing regulation by long noncoding RNAs.
Q37678494Stressing on the nucleolus in cardiovascular disease
Q33803135Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments
Q49340786Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach.
Q36328119Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells
Q60167186Subnuclear compartmentalization and function of actin and nuclear Myosin I in plants
Q39171387Synaptic Vesicle Clusters at Synapses: A Distinct Liquid Phase?
Q27683159Synchronizing nuclear import of ribosomal proteins with ribosome assembly
Q35787589Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines
Q42319834Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice
Q38194418Targeting RNA polymerase I to treat MYC-driven cancer.
Q44673965Targeting RNA polymerase I transcription and the nucleolus for cancer therapy
Q33951245Telomerase trafficking and assembly in Xenopus oocytes
Q91991777The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression
Q34047421The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?
Q38439235The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence
Q37777278The EspF effector, a bacterial pathogen's Swiss army knife
Q50472786The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.
Q24336283The F-actin filament capping protein CapG is a bona fide nucleolar protein
Q64071542The Functions of Non-coding RNAs in rRNA Regulation
Q24336786The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression
Q41092829The IGH locus relocalizes to a "recombination compartment" in the perinucleolar region of differentiating B-lymphocytes.
Q35683964The Inner Nuclear Membrane Protein Src1 Is Required for Stable Post-Mitotic Progression into G1 in Aspergillus nidulans
Q50302535The Multiple Functions of the Nucleolus in Plant Development, Disease and Stress Responses.
Q92882455The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control
Q28513482The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
Q57166264The Nucleolus
Q34793398The Nucleolus Takes Control of Protein Trafficking Under Cellular Stress
Q46302852The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides
Q45357395The R-rich motif of Beet black scorch virus P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity.
Q36189664The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.
Q35103161The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine
Q39153670The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD.
Q24293286The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex
Q36356204The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis
Q90311606The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers
Q35662490The Up-Regulation of Ribosomal Proteins Further Regulates Protein Expression Profile in Female Schistosoma japonicum after Pairing
Q39944723The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway
Q54650094The actin family protein ARP6 contributes to the structure and the function of the nucleolus.
Q37484539The cell's nucleolus: an emerging target for chemotherapeutic intervention
Q53309299The chromosome peripheral proteins play an active role in chromosome dynamics.
Q60046645The conservation landscape of the human ribosomal RNA gene repeats
Q37718645The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.
Q30503221The dynamics of the alternatively spliced NOL7 gene products and role in nucleolar architecture
Q41130845The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage
Q28474712The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction
Q27931464The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2
Q37843675The function of spliceosome components in open mitosis
Q36199312The histone chaperone DAXX maintains the structural organization of heterochromatin domains
Q35005892The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells
Q48646158The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture.
Q33302679The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in Arabidopsis thaliana
Q57944749The involvement of tau in nucleolar transcription and the stress response
Q38122214The multifunctional RNase XRN2.
Q34654485The nuclear import of ribosomal proteins is regulated by mTOR
Q46293920The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner.
Q40341941The nucleoid as a site of rRNA processing and ribosome assembly
Q34018501The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability
Q38515093The nucleolar interface of RNA viruses
Q34040075The nucleolar phosphoprotein B23 targets Newcastle disease virus matrix protein to the nucleoli and facilitates viral replication
Q59352771The nucleolar protein LYAR facilitates ribonucleoprotein assembly of influenza A virus
Q41905674The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription
Q34151727The nucleolus
Q98891955The nucleolus as a multiphase liquid condensate
Q35936761The nucleolus of Caenorhabditis elegans
Q24597470The nucleolus under stress
Q92138912The nucleolus: a central response hub for the stressors that drive cancer progression
Q34450199The nucleolus: a raft adrift in the nuclear sea or the keystone in nuclear structure?
Q39149725The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization
Q33884719The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma
Q37294759The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway
Q33553863The proteins of intra-nuclear bodies: a data-driven analysis of sequence, interaction and expression
Q34038183The role of nuclear bodies in gene expression and disease
Q38003178The role of the TRAF-interacting protein in proliferation and differentiation
Q37217674The role of the plant nucleolus in pre-mRNA processing.
Q34549594The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells
Q34367527The shared genomic architecture of human nucleolar organizer regions.
Q37264888The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events
Q34538530The traffic of proteins between nucleolar organizer regions and prenucleolar bodies governs the assembly of the nucleolus at exit of mitosis
Q38905460The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies
Q90133019Therapeutic Approaches Targeting Nucleolus in Cancer
Q33375595Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes
Q37019644Toward a high-resolution view of nuclear dynamics
Q39104068Towards cancer cell-specific phototoxic organometallic rhenium(I) complexes.
Q90418667Tracking the cargo of extracellular symbionts into host tissues with correlated electron microscopy and nanoscale secondary ion mass spectrometry imaging
Q38381579Transcription by the multifunctional RNA polymerase I in Trypanosoma brucei functions independently of RPB7.
Q46913528Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus
Q47137849Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy
Q37361938Transcriptional control of gene expression by actin and myosin
Q38594197Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.
Q33655308Transcriptome profiling confirmed correlations between symptoms and transcriptional changes in RDV infected rice and revealed nucleolus as a possible target of RDV manipulation
Q49237340Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells.
Q38260151Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells
Q36555212Translational control in cancer etiology
Q35151149Transplantation of nucleoli into human zygotes: not as simple as expected?
Q36983088Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure
Q36670157Troponin T nuclear localization and its role in aging skeletal muscle
Q58102551Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus
Q39025278UBF complexes with phosphatidylinositol 4,5-bisphosphate in nucleolar organizer regions regardless of ongoing RNA polymerase I activity
Q34347040Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.
Q34043979Upstream binding factor inhibits herpes simplex virus replication.
Q41039658Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
Q33326968Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1
Q91705481Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics
Q37975989Using SILAC and quantitative proteomics to investigate the interactions between viral and host proteomes
Q35186326Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli
Q52431094Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system.
Q50001850Vertebrate Genome Evolution in the Light of Fish Cytogenomics and rDNAomics.
Q47151158Viral Impact in Autoimmune Diseases: Expanding the "X Chromosome-Nucleolus Nexus" Hypothesis
Q56551555Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response
Q37944142Virus manipulation of cell cycle.
Q38174760Viruses and the nucleolus: the fatal attraction.
Q27331401Widespread expression of BORIS/CTCFL in normal and cancer cells
Q35143028ZBED6 modulates the transcription of myogenic genes in mouse myoblast cells
Q41962988ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals
Q91936455Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
Q34592838mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3
Q38202877p53 -Dependent and -Independent Nucleolar Stress Responses
Q41124443rDNA-directed integration by an HIV-1 integrase--I-PpoI fusion protein
Q36016790rRNA genes are not fully activated in mouse somatic cell nuclear transfer embryos

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