Coactivator and corepressor complexes in nuclear receptor function

scientific article (publication date: April 1999)

Coactivator and corepressor complexes in nuclear receptor function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0959-437X(99)80021-5
P3181OpenCitations bibliographic resource ID1663200
P698PubMed publication ID10322133

P2093author name stringXu L
Rosenfeld MG
Glass CK
P2860cites workChromatin deacetylation by an ATP-dependent nucleosome remodelling complexQ22004265
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complexQ22009519
Composite co-activator ARC mediates chromatin-directed transcriptional activationQ22009528
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressorQ24311650
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylaseQ29547913
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor functionQ29547918
Role of CBP/P300 in nuclear receptor signallingQ29616443
Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activationQ33886757
Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) geneQ34460757
p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiationQ35189958
Proteasomal regulation of nuclear receptor corepressor-mediated repressionQ35202493
Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitroQ35210134
Signal-specific co-activator domain requirements for Pit-1 activationQ41006466
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activatorsQ41007539
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.Q41010869
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiationQ41038113
Transcription properties of a cell type-specific TATA-binding protein, TRF.Q41086793
MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids.Q41308304
Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machinesQ41708885
The p300/CBP family: integrating signals with transcription factors and chromatinQ45155861
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complexQ24311791
Histone-like TAFs within the PCAF histone acetylase complexQ24317520
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathwaysQ24320338
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300Q24324556
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1AQ24336667
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayQ24598533
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free systemQ24601592
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptorsQ24646387
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gammaQ27765353
Structure and specificity of nuclear receptor-coactivator interactionsQ27765991
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesisQ27860471
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptorsQ27860552
The transcriptional coactivators p300 and CBP are histone acetyltransferasesQ27860843
A signature motif in transcriptional co-activators mediates binding to nuclear receptorsQ27860938
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complexQ27934812
The CBP co-activator is a histone acetyltransferaseQ28131758
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancerQ28245902
Steroid receptor coactivator-1 is a histone acetyltransferaseQ28248899
RNA helicase A mediates association of CBP with RNA polymerase IIQ28250576
Transcription factor-specific requirements for coactivators and their acetyltransferase functionsQ28260156
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300Q28270979
Differential roles of p300 and PCAF acetyltransferases in muscle differentiationQ28276083
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factorsQ28279441
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activitiesQ28286772
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptorQ28286827
A transcriptional co-repressor that interacts with nuclear hormone receptorsQ28289864
Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complexQ28569621
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activationQ28577247
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repressionQ28578229
Histone acetylation and transcriptional regulatory mechanismsQ29547707
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)140-7
P577publication date1999-04-01
P1433published inCurrent Opinion in Genetics & DevelopmentQ13505684
P1476titleCoactivator and corepressor complexes in nuclear receptor function
P478volume9

Reverse relations

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Q44290665Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta
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Q24540319MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
Q44010956MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance.
Q52571560Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription.
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Q34064165Mechanism of action of estrogens and selective estrogen receptor modulators
Q47638286Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication
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Q34099654Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.
Q35901064Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.
Q34328117Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones
Q36328486Metabolic stress in the myocardium: adaptations of gene expression.
Q74234880Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells
Q40219178Microarray analysis of gene-expression profile in hepatocellular carcinoma cell, BEL-7402, with stable suppression of hLRH-1 via a DNA vector-based RNA interference
Q34658571Modelling haematopoietic malignancies in the mouse and therapeutical implications
Q28579299Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways
Q34519720Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains
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Q35062563Molecular action of androgens
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Q36389347Molecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes
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Q35062458Mouse cancer models as a platform for performing preclinical therapeutic trials
Q50335765Multimeric Coactivator Complexes for Steroid/Nuclear Receptors.
Q36002736Multiple mechanisms of growth hormone-regulated gene transcription
Q28218138Murine Sall1 represses transcription by recruiting a histone deacetylase complex
Q35687733Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor
Q48327642NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Q24298650NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors
Q24318233Negative modulation of androgen receptor transcriptional activity by Daxx
Q34268802New insights into receptor ligand binding domains from a novel assembly assay
Q40191181Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster
Q55884279NuRD and SIN3
Q36772290Nuclear Receptor Cofactors in PPARgamma-Mediated Adipogenesis and Adipocyte Energy Metabolism
Q46735339Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer
Q38234421Nuclear receptor Rev-erbα: up, down, and all around
Q36589100Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo
Q33745092Nuclear receptor cofactors as chromatin remodelers
Q34537625Nuclear receptor coregulators: multiple modes of modification
Q40743785Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation
Q41639915Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis
Q34666809Nuclear receptor regulation of hepatic function
Q26825692Nuclear receptors and their selective pharmacologic modulators
Q38766346Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Q34282476Nuclear-receptor interactions on DNA-response elements
Q53408223Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Q42779812Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1.
Q33961750Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells
Q22254231Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA
Q44594527Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor α
Q28115180PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation
Q40355706PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis
Q34300756PIASy-mediated repression of the androgen receptor is independent of sumoylation
Q34896634PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence
Q46484275PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose
Q42584983PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1
Q34181759Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region
Q37891181Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease
Q28345519Peroxisomal bifunctional enzyme binds and activates the activation function-1 region of the peroxisome proliferator-activated receptor alpha
Q34405645Peroxisome proliferator-activated receptor (PPAR) modulators: diabetes and beyond
Q28513089Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development
Q39663357Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells
Q34236635Phosphorylation and activation of androgen receptor by Aurora-A
Q34795858Polymorphisms in the vitamin D Receptor (VDR) and the risk of ovarian cancer: a meta-analysis
Q39940557Post-TATA Binding Protein Recruitment Clearance of Gcn5-Dependent Histone Acetylation within Promoter Nucleosomes
Q45223754Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine
Q91762131Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease
Q36363049Potential uses of T3 in the treatment of human disease
Q24323389Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression
Q24297189Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene
Q34136185Proteins interacting with the mammalian estrogen receptor: proposal for an integrated model for estrogen receptor mediated regulation of transcription
Q44214643Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism
Q24338281Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells
Q33292217Prothymosin alpha associates with the oncoprotein SET and is involved in chromatin decondensation
Q24552170Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity
Q34236652Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities
Q24322855Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription
Q31892738Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes
Q73230918RAC-3 is a NF-kappa B coactivator
Q40565112RARgamma acts as a tumor suppressor in mouse keratinocytes
Q28217579RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding
Q37277846Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development
Q28377418Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions
Q33903836Redefining hormone resistance in prostate cancer
Q61818422Redoxins as gatekeepers of the transcriptional oxidative stress response
Q35874448Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.
Q47393112Regulation of Signal Transduction by DJ-1.
Q44616310Regulation of androgen receptor expression at the onset of functional overload in rat plantaris muscle
Q33882753Regulation of cytochrome P450 (CYP) genes by nuclear receptors.
Q37256023Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation
Q22254367Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
Q32062002Regulation of mouse kappa opioid receptor gene expression by retinoids.
Q42481656Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction
Q33922396Regulation of retinoic acid signaling in the embryonic nervous system: a master differentiation factor
Q37477712Regulatory diversity of TUP1 in Cryptococcus neoformans
Q39124248Relationship between epigenetic regulation, dietary habits, and the developmental origins of health and disease theory
Q52174747Repression and activation of transcription of phosphoenolpyruvate carboxykinase gene during liver development.
Q37084818Repression of the cardiac myosin light chain-2 gene in skeletal muscle requires site-specific association of antithetic regulator, Nished, and HDACs
Q40701086Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function
Q37175201Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing
Q24291241Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription
Q31114537Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines
Q40609894Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell line
Q34244416Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.
Q37062449Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties
Q34004662Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms
Q24537553Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter
Q24323284Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter
Q37598771Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
Q45286557Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon.
Q35217391Retinoid target genes in acute promyelocytic leukemia
Q34098068Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins
Q36509253Retinoid-dependent restriction of human immunodeficiency virus type 1 replication in monocytes/macrophages
Q34770626Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development.
Q24642725Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
Q34976906Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
Q35567239Retinoids in cancer therapy and chemoprevention: promise meets resistance
Q37788067Retinoids regulate stem cell differentiation
Q28564938Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5
Q37973431Role of PPARg2 transcription factor in thiazolidinedione-induced insulin sensitization
Q34290239Role of protein methylation in chromatin remodeling and transcriptional regulation
Q34541307Role of transcription factors in the pathogenesis of pituitary adenomas: a review
Q31798023Role reversal: new insights from new ligands for the xenobiotic receptor CAR.
Q26796409Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases
Q30440069SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
Q35641879STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression
Q33947738Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1
Q24540092Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
Q24302292Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene
Q47229962Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis
Q28190290Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1
Q40625890Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors.
Q33677015Signaling routes to CREM and CREB: plasticity in transcriptional activation.
Q36871666Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex
Q35964130Sin3: a flexible regulator of global gene expression and genome stability.
Q37061970Smad-Dependent Recruitment of a Histone Deacetylase/Sin3A Complex Modulates the Bone Morphogenetic Protein-Dependent Transcriptional Repressor Activity of Nkx3.2
Q36197069Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation
Q44185391Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action
Q31440310Steroid hormone activity of flavonoids and related compounds.
Q33813420Steroid hormone receptors: evolution, ligands, and molecular basis of biologic function.
Q36421655Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin
Q33987672Steroid regulation of postembryonic development and reproduction in Drosophila
Q43925897Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes
Q40362927Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells
Q33813416Strategies for transcriptional activation by steroid/nuclear receptors
Q24336232Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor
Q40877928Structural and functional divergence of a nuclear receptor of the RXR family from the trematode parasite Schistosoma mansoni
Q28594313Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
Q27641089Structural basis for bile acid binding and activation of the nuclear receptor FXR
Q35104166Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Q27630646Structural insights into the mode of action of a pure antiestrogen
Q47145058Structure and Functional Analysis of Promoters from Two Liver Isoforms of CPT I in Grass Carp Ctenopharyngodon idella.
Q40641807Subcellular localization and mechanisms of nucleocytoplasmic trafficking of steroid receptor coactivator-1.
Q36017139Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPARγ Antagonism
Q43583333Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A.
Q44586126Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays
Q38177196Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
Q21284161TBLR1 regulates the expression of nuclear hormone receptor co-repressors
Q24300818TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
Q28255619TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription
Q24537630TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.
Q37284561Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development
Q34732688Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-erbA yields a chromatin infrastructure-dependent transcriptional repression pathway
Q38441104TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions
Q24607892TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins
Q39458882Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
Q35131700Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases
Q30430463Tgif1 represses apolipoprotein gene expression in liver
Q37332415The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain
Q24523980The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
Q24292680The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor
Q35040153The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair
Q24816133The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses
Q28513184The PCAF acetylase complex as a potential tumor suppressor
Q34090732The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
Q28343797The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)
Q39455172The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
Q36957831The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.
Q42004851The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry.
Q28378184The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system
Q73515650The control of Xenopus embryonic primary neurogenesis is mediated by retinoid signalling in the neurectoderm
Q35043461The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response
Q45179478The effect of sodium butyrate in combination with ATRA on the proliferation/differentiation of SKM-1.
Q24537671The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.
Q24600264The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor
Q28202057The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation
Q24336423The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling
Q24548305The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage
Q38697860The nature of the GRE influences the screening for GR-activity enhancing modulators.
Q39705022The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells
Q24554362The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
Q24815982The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction.
Q34365414The role of SGK1 in hormone-regulated sodium transport
Q35671179The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors
Q35193858The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation.
Q39597497The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
Q42153519The transcriptional co-activator cAMP response element-binding protein-binding protein is expressed in prostate cancer and enhances androgen- and anti-androgen-induced androgen receptor function
Q28285366The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains
Q37140783Thyroid hormone and cerebellar development
Q50026830Thyroid hormone receptor localization in target tissues.
Q35802818Thyroid hormone receptor subtypes and their interaction with steroid receptor coactivators
Q24678281Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
Q35230257Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult Mammalian brain
Q43938722Thyroid hormone regulation of a transcriptional coactivator in Xenopus laevis: implication for a role in postembryonic tissue remodeling
Q34047802Thyroid hormone regulation of apoptotic tissue remodeling: implications from molecular analysis of amphibian metamorphosis
Q30940081Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element
Q39218620Time-integrated fluorescence cumulant analysis and its application in living cells
Q28251356Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation
Q52049507Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.
Q28386593To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
Q37454297Trans-regulation of histone deacetylase activities through acetylation
Q28651703Transcript profiling of Populus tomentosa genes in normal, tension, and opposite wood by RNA-seq
Q39644401Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity
Q28189040Transcriptional activation by STAT6 requires the direct interaction with NCoA-1
Q38660201Transcriptional activation by hepatocyte nuclear factor-4 in a cell-free system derived from rat liver nuclei
Q51494268Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.
Q35127128Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP16
Q28199910Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250
Q33898960Transcriptional control of T cell development
Q33851832Transcriptional regulation by cyclic AMP-responsive factors
Q34401921Transcriptional regulation of hemopoiesis
Q33904338Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
Q40816966Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor
Q45872399Transcriptionally active drugs improve adenovirus vector performance in vitro and in vivo
Q44333035Triiodothyronine-mediated myosin heavy chain gene transcription in the heart
Q35781803Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.
Q28366303Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Q36344273Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor
Q24530630WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8
Q27641169X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch
Q42620669XTIF2, a Xenopus homologue of the human transcription intermediary factor, is required for a nuclear receptor pathway that also interacts with CBP to suppress Brachyury and XMyoD.
Q38921373Zebrafish retinoic acid receptors function as context-dependent transcriptional activators
Q30156984c-Abl regulates estrogen receptor alpha transcription activity through its stabilization by phosphorylation
Q33968417p300 forms a stable, template-committed complex with chromatin: role for the bromodomain
Q33199648p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

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