Sak kinase Dmel_CG7186

Protein found in Drosophila melanogaster

Sak kinase Dmel_CG7186 is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDFBpp0078042
P637RefSeq protein IDNP_649324
P352UniProt protein IDO97143

P682biological processphosphorylationQ242736
protein autophosphorylationQ3630494
centrosome cycleQ5063037
protein phosphorylationQ7251493
regulation of protein stabilityQ14863403
positive regulation of protein catabolic processQ14865069
male meiotic nuclear divisionQ14911711
centriole replicationQ21097393
regulation of centriole replicationQ21105087
sperm axoneme assemblyQ21112596
syncytial blastoderm mitotic cell cycleQ22298060
P681cell componentcytoplasmQ79899
cytoskeletonQ154626
centrosomeQ190769
centrioleQ178355
cytosolQ220599
P702encoded bySAKQ29714869
P703found in taxonDrosophila melanogasterQ130888
P527has part(s)Plk4, first cryptic polo-box domainQ24722086
tyrosine-protein kinase, active siteQ24738472
POLO box domainQ24739695
protein kinase domainQ24768234
protein kinase, ATP binding siteQ24769051
Plk4, second cryptic polo-box domainQ24772230
Plk4, C-terminal polo-box domainQ24778596
P680molecular functionprotein bindingQ167149
protein serine/threonine kinase activityQ14326094
identical protein bindingQ14762994
ATP bindingQ14817981
protein kinase activityQ14820641
transferase activityQ14840131
nucleotide bindingQ14860365
kinase activityQ14863082
P361part ofProtein kinase-like domain superfamilyQ24726164
Serine/threonine-protein kinase Plk4Q24773301
Plk4, first cryptic polo-box domain, protein familyQ83133605
POLO box domain, protein familyQ83136884
Protein kinase domain, protein familyQ83138186
Plk4, second cryptic polo-box domain, protein familyQ83145995
Plk4, C-terminal polo-box domain, protein familyQ83146489
Tyrosine-protein kinase, active site, protein familyQ95352684
Protein kinase, ATP binding site, protein familyQ95354221

Reverse relations

main subject (P921)
Q43138655A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication
Q24300230Asterless is a scaffold for the onset of centriole assembly
Q42871178DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement
Q47072860From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages
Q42331871Klp10A modulates the localization of centriole-associated proteins during Drosophila male gametogenesis
Q35830134Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.
Q34472675SAK/PLK4 is required for centriole duplication and flagella development
Q27684497Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases
Q35406563The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification
Q37124885The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.
Q27673542The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

Q29714869SAKencodesP688

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