Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes

scientific article (publication date: 2017)

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FMICB.2017.00546
P932PMC publication ID5376627
P698PubMed publication ID28421048

P50authorAlfredo Berzal-HerranzQ41482458
P2093author name stringPablo Ríos-Marco
Cristina Romero-López
Alba Fernández-Sanlés
P2860cites workRNA Secondary Structure in the Coding Region of Dengue Virus Type 2 Directs Translation Start Codon Selection and Is Required for Viral ReplicationQ22337047
A 5' RNA element promotes dengue virus RNA synthesis on a circular genomeQ22337098
Evidence for the Existence of a Pseudoknot Structure at the 3‘ Terminus of the Flavivirus Genomic RNA †Q22337292
Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replicationQ22337310
A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmissionQ22337371
A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for PathogenicityQ22337381
Kissing-loop interaction between 5' and 3' ends of tick-borne Langat virus genome 'bridges the gap' between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine developmentQ24289179
Phylogeny of the Genus FlavivirusQ24471099
Identification of Specific Nucleotide Sequences within the Conserved 3′-SL in the Dengue Type 2 Virus Genome Required for ReplicationQ24523550
Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replicationQ24538975
Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibitedQ24544261
Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomesQ24556622
Accumulation of a 3'-terminal genome fragment in Japanese encephalitis virus-infected mammalian and mosquito cellsQ24567669
The polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machineryQ24658300
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virusQ24678543
Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA.Q24816212
A single siRNA suppresses fatal encephalitis induced by two different flavivirusesQ25255046
Molecular evolution of the insect-specific flavivirusesQ26824596
Molecular characterization of virus-specific RNA produced in the brains of flavivirus-susceptible and -resistant mice after challenge with Murray Valley encephalitis virusQ27107400
RNA structures required for production of subgenomic flavivirus RNAQ27107485
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replicationQ27469445
Size heterogeneity in the 3' noncoding region of South American isolates of yellow fever virusQ27469453
Mov34 protein from mouse brain interacts with the 3' noncoding region of Japanese encephalitis virusQ27469595
Dengue virus structural differences that correlate with pathogenesis.Q27469705
Essential role of cyclization sequences in flavivirus RNA replicationQ27469848
West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and InfectionQ27472821
Sequence comparison and secondary structure analysis of the 3' noncoding region of flavivirus genomes reveals multiple pseudoknots.Q27472958
Fine Mapping of a cis-Acting Sequence Element in Yellow Fever Virus RNA That Is Required for RNA Replication and CyclizationQ27473090
Functional analysis of the tick-borne encephalitis virus cyclization elements indicates major differences between mosquito-borne and tick-borne flavivirusesQ27473146
West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5Q27477465
Regulation of flavivirus RNA synthesis and cappingQ38127643
Unmasking the information encoded as structural motifs of viral RNA genomes: a potential antiviral target.Q38132094
Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responsesQ38182831
RNA Aptamers as Molecular Tools to Study the Functionality of the Hepatitis C Virus CRE Region.Q38296535
RNA aptamer‐mediated interference of HCV replication by targeting the CRE‐5BSL3.2 domainQ38318690
Functional non-coding RNAs derived from the flavivirus 3' untranslated region.Q38347334
Mutational analysis of three predicted 5′-proximal stem-loop structures in the genome of tick-borne encephalitis virus indicates different roles in RNA replication and translationQ38587440
Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regionsQ39034822
The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR.Q39096182
Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cellsQ39140481
Sequences of terminal non-coding regions from four dengue-2 viruses isolated from patients exhibiting different disease severitiesQ39210411
Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cellsQ39266291
Genetic variation in the 3' non-coding region of dengue viruses.Q39460462
Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3’ UTR structuresQ39466005
The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesisQ39563110
Translational regulation by the 3' untranslated region of the dengue type 2 virus genomeQ39782724
Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells.Q39810745
Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiencyQ39883721
Nucleic acids-based therapeutics in the battle against pathogenic virusesQ37338992
Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathwayQ37511523
Replication cycle and molecular biology of the West Nile virusQ37566687
Control of dengue virus translation and replicationQ37608056
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNAQ37670700
Structure and Function of Flavivirus NS5 MethyltransferaseQ27478377
Inhibition of dengue virus by novel, modified antisense oligonucleotidesQ27478439
Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assemblyQ27478442
Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pHQ27478446
BHK cell proteins that bind to the 3' stem-loop structure of the West Nile virus genome RNAQ27480296
Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeysQ27480386
Subgenomic replicons of the flavivirus Kunjin: construction and applicationsQ27480783
RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNAQ27480815
Translation elongation factor-1 alpha interacts with the 3' stem-loop region of West Nile virus genomic RNAQ27480847
Functional Analysis of Mosquito-Borne Flavivirus Conserved Sequence Elements within 3' Untranslated Region of West Nile Virus by Use of a Reporting Replicon That Differentiates between Viral Translation and RNA ReplicationQ27485398
West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of v 3 IntegrinQ27486120
Identification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine CandidateQ27486407
Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNAQ27486408
Presence of poly(A) in a flavivirus: significant differences between the 3' noncoding regions of the genomic RNAs of tick-borne encephalitis virus strainsQ27486540
A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replicationQ27486794
Structural and Functional Studies of the Promoter Element for Dengue Virus RNA ReplicationQ27487528
Conformational Changes in the Solution Structure of the Dengue Virus 5' End in the Presence and Absence of the 3' Untranslated RegionQ27487533
The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesisQ27487755
Extension of Flavivirus Protein C Differentially Affects Early RNA Synthesis and Growth in Mammalian and Arthropod Host CellsQ27490326
Inhibition of west nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cellsQ27490949
The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) ProductionQ27683468
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolutionQ27861057
Insect-specific flaviviruses: a systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organizationQ28087355
Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNAQ28201031
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress ResponsesQ28222114
Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4BQ28538841
Molecular archaeology of Flaviviridae untranslated regions: duplicated RNA structures in the replication enhancer of flaviviruses and pestiviruses emerged via convergent evolutionQ28657429
Novel cis-acting element within the capsid-coding region enhances flavivirus viral-RNA replication by regulating genome cyclizationQ28681742
Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 proteinQ39938749
West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactionsQ40015473
West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA proteinQ40065552
LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.Q40160687
Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathwayQ40225767
RNA sequences and structures required for the recruitment and activity of the dengue virus polymeraseQ40339851
The 5′ and 3′ Downstream AUG Region Elements Are Required for Mosquito-Borne Flavivirus RNA ReplicationQ40341823
A balance between circular and linear forms of the dengue virus genome is crucial for viral replicationQ40345189
Polypyrimidine tract-binding protein interacts with the 3' stem-loop region of Japanese encephalitis virus negative-strand RNA.Q40369486
Effective siRNA targeting of the 3' untranslated region of the West Nile virus genomeQ40399935
Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replicationQ40400756
Genetic analysis of Dengue 3 virus subtype III 5' and 3' non-coding regionsQ40420910
Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease.Q40456251
The topology of bulges in the long stem of the flavivirus 3' stem-loop is a major determinant of RNA replication competence.Q40463743
Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domainQ40505445
Use of RNA interference to prevent lethal murine west nile virus infectionQ40513711
La protein binds to NS5 and NS3 and to the 5' and 3' ends of Dengue 4 virus RNA.Q40535972
A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replicationQ40561378
In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structureQ40605432
Biological consequences of deletions within the 3'-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structureQ40631644
Role of heparan sulfate for attachment and entry of tick-borne encephalitis virusQ40653641
Genetic variation in yellow fever virus: duplication in the 3' noncoding region of strains from AfricaQ40661126
Growth-restricted dengue virus mutants containing deletions in the 5' noncoding region of the RNA genomeQ40688553
The 3' stem loop of the West Nile virus genomic RNA can suppress translation of chimeric mRNAsQ40786257
The 3'-nucleotides of flavivirus genomic RNA form a conserved secondary structureQ40806302
Analysis of structural properties which possibly are characteristic for the 3'-terminal sequence of the genome RNA of flavivirusesQ40807806
Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its geneQ41482972
Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesisQ41853781
Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus.Q42026897
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vectorQ42670333
Inhibition of West Nile virus replication in cells stably transfected with vector-based shRNA expression systemQ42978821
Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5' and 3'-UTRsQ42983161
La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replicationQ42985916
The majority of the nucleotides in the top loop of the genomic 3' terminal stem loop structure are cis-acting in a West Nile virus infectious cloneQ42989753
The flavivirus-conserved penta-nucleotide in the 3' stem-loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translationQ42989770
RNA elements within the 5' untranslated region of the West Nile virus genome are critical for RNA synthesis and virus replicationQ42993642
Nucleotide sequence of the 5'-terminal untranslated part of the genome of the flavivirus West Nile virusQ42993966
Characterization of glycoprotein E C-end of West Nile virus and evaluation of its interaction force with alphaVbeta3 integrin as putative cellular receptor.Q42998365
Expression of vector-based small interfering RNA against West Nile virus effectively inhibits virus replicationQ43001536
Terminal sequences of the genome and replicatioe-form RNA of the flavivirus west nile virus: absence of poly(A) and possible role in RNA replicationQ43034322
Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?Q43039582
Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flavivirusesQ43049498
RNA based evolutionary optimizationQ45131634
Composition and three-dimensional architecture of the dengue virus replication and assembly sitesQ29615112
A structural perspective of the flavivirus life cycleQ29616269
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfateQ29618060
The molecular biology of West Nile Virus: a new invader of the western hemisphereQ29620664
Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequencesQ29620940
Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteinsQ30403343
The endoplasmic reticulum provides the membrane platform for biogenesis of the flavivirus replication complexQ30484619
Genome sequence analysis of Tamana bat virus and its relationship with the genus FlavivirusQ30724279
Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replicationQ33877404
Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies.Q34112867
An RNA Pseudoknot Is Required for Production of Yellow Fever Virus Subgenomic RNA by the Host Nuclease XRN1Q34133213
Error catastrophe and antiviral strategyQ34153584
New inferences from tree shape: numbers of missing taxa and population growth ratesQ34173397
The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA virusesQ34227618
AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genomeQ34261742
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stabilityQ34301595
Conserved RNA secondary structures in Flaviviridae genomesQ34315929
Flaviviral RNAs: weapons and targets in the war between virus and hostQ34432758
Host factors involved in West Nile virus replication.Q34498823
Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA.Q34553290
West Nile virus (WNV) genome RNAs with up to three adjacent mutations that disrupt long distance 5'-3' cyclization sequence basepairs are viableQ34669442
RNA Structure Duplications and Flavivirus Host AdaptationQ34675614
Identification of Cis-Acting Elements in the 3′-Untranslated Region of the Dengue Virus Type 2 RNA That Modulate Translation and ReplicationQ35063142
FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replicationQ35076660
Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replicationQ35111041
Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA.Q35362977
Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairingsQ35448745
Cap-dependent and cap-independent translation in eukaryotic systemsQ35773948
West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral responseQ35943585
Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAsQ36553913
Origin and evolution of 3'UTR of flaviviruses: long direct repeats as a basis for the formation of secondary structures and their significance for virus transmissionQ36707763
Structural complexity of Dengue virus untranslated regions: cis -acting RNA motifs and pseudoknot interactions modulating functionality of the viral genomeQ36814248
A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoesQ36931812
Identification of cis -Acting Nucleotides and a Structural Feature in West Nile Virus 3′-Terminus RNA That Facilitate Viral Minus Strand RNA SynthesisQ36978834
Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication ElementQ37148673
P407language of work or nameEnglishQ1860
P304page(s)546
P577publication date2017-01-01
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleFunctional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes
P478volume8

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