c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential

scientific article

c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01731-08
P932PMC publication ID2772728
P698PubMed publication ID19704002

P2093author name stringHarold Kim
William J Muller
Richard Marcotte
Lixin Zhou
Calvin D Roskelly
P2860cites workNewest findings on the oldest oncogene; how activated src does itQ24313514
pp60c-src activation in human colon carcinomaQ24623701
Activation and association of Stat3 with Src in v-Src-transformed cell linesQ24650319
A new model for ductal carcinoma in situ suggests strategies for treatmentQ24802734
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Docking interactions in protein kinase and phosphatase networksQ28271644
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptorQ28302317
Epidermal growth factor receptor mutations in lung cancerQ29615474
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activationQ30160222
Structure and regulation of Src family kinasesQ30160827
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreadingQ30167497
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.Q52572763
Activation segment exchange: a common mechanism of kinase autophosphorylation?Q57937233
Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancersQ70200246
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic miceQ71606712
Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptorQ71703153
Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.Q30177032
Involvement of pp60c-src with two major signaling pathways in human breast cancerQ30194582
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor functionQ30303639
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancersQ30453944
Mechanism of biological synergy between cellular Src and epidermal growth factor receptorQ30454480
Role of c-Src tyrosine kinase in EGF-induced mitogenesis.Q30471125
Stat3 activation is required for cellular transformation by v-srcQ33786469
Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion geneQ34012640
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial aciniQ34187916
Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.Q34250172
Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinaseQ34383658
c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysisQ34414942
ErbB receptors: new insights on mechanisms and biologyQ34579265
Endocytosis and intracellular trafficking of ErbBsQ34827744
Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expressionQ35566222
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activityQ35641650
The road to Src.Q35920886
New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionallyQ36219999
ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinasesQ36326248
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinomaQ36423957
Association of p60c-src with endosomal membranes in mammalian fibroblastsQ36533201
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activityQ36644521
Epidermal growth factor receptor mutations in lung cancers.Q36817294
Epidermal growth factor receptor degradation: an alternative view of oncogenic pathways.Q36940317
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular traffickingQ37074180
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.Q40135901
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomesQ40156909
Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptideQ40336968
The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.Q40371716
Activation of the Src family of tyrosine kinases in mammary tumorigenesis.Q40605904
Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cellsQ40613260
MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transitionQ40710204
Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptorQ41075249
A new 180 kDa. urine protein marker associated with bladder cancerQ41188835
Activation of Src family kinases in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo.Q41273163
c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.Q41281287
Site-specific association of c-Src with epidermal growth factor receptor in A431 cellsQ41344115
The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutantsQ42095201
Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesisQ42796653
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cellsQ42805935
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cellsQ42807469
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)5858-5871
P577publication date2009-08-24
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlec-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential
P478volume29

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cites work (P2860)
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Q39605666Src kinase mediates productive endocytic sorting of reovirus during cell entry.
Q35207876Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells
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Q34323926Tissue phosphoproteomics with PolyMAC identifies potential therapeutic targets in a transgenic mouse model of HER2 positive breast cancer.

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