| scholarly article | Q13442814 |
| P2093 | author name string | Nadia Okolowsky | |
| Paul A Hamel | |||
| Andrew Fleet | |||
| Malcolm C Harvey | |||
| P2860 | cites work | Characterization of two patched receptors for the vertebrate hedgehog protein family | Q22007983 |
| Patched1 interacts with cyclin B1 to regulate cell cycle progression | Q24291186 | ||
| Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development | Q24293428 | ||
| Regulation of patched by sonic hedgehog in the developing neural tube | Q24594414 | ||
| The role of Src in solid tumors | Q24616659 | ||
| All Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved Manner | Q27662102 | ||
| Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling | Q28141240 | ||
| Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse | Q71586920 | ||
| Patched acts catalytically to suppress the activity of Smoothened | Q28218828 | ||
| Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila | Q28254980 | ||
| Human homolog of patched, a candidate gene for the basal cell nevus syndrome | Q28281033 | ||
| Patched1 functions as a gatekeeper by promoting cell cycle progression | Q28298227 | ||
| Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes | Q28304824 | ||
| Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1 | Q28504970 | ||
| A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc) | Q28508239 | ||
| Boc is a receptor for sonic hedgehog in the guidance of commissural axons | Q28508434 | ||
| Altered neural cell fates and medulloblastoma in mouse patched mutants | Q28588056 | ||
| The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development | Q28591956 | ||
| The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice | Q28592320 | ||
| Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1. | Q30010014 | ||
| Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling | Q30156870 | ||
| c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential | Q30157161 | ||
| Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene | Q34012640 | ||
| Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function | Q34191681 | ||
| Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32. | Q34490781 | ||
| Activation of heterotrimeric G proteins by Smoothened | Q35033814 | ||
| Hedgehog pathway as a drug target: Smoothened inhibitors in development | Q35885181 | ||
| Reduced white fat mass in adult mice bearing a truncated Patched 1 | Q36452779 | ||
| Expression of activated oncogenes in the murine mammary gland: transgenic models for human breast cancer | Q36453905 | ||
| Gli1 is a target of Sonic hedgehog that induces ventral neural tube development | Q36870138 | ||
| Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation | Q37175840 | ||
| Src kinases as therapeutic targets for cancer | Q37604891 | ||
| Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo). | Q37633966 | ||
| Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists | Q37902802 | ||
| Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins | Q37960450 | ||
| Clinical significance of Src expression and activity in human neoplasia | Q37999702 | ||
| Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways | Q38944567 | ||
| Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice | Q40182155 | ||
| The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. | Q40371716 | ||
| Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation | Q42103359 | ||
| Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. | Q42439709 | ||
| Alteration of the PATCHED locus in superficial bladder cancer | Q42442038 | ||
| Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling | Q42805992 | ||
| In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex | Q47071082 | ||
| Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb | Q48065396 | ||
| Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. | Q52163161 | ||
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 10939-10949 | |
| P577 | publication date | 2014-02-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Distinct effects of the mesenchymal dysplasia gene variant of murine Patched-1 protein on canonical and non-canonical Hedgehog signaling pathways | |
| P478 | volume | 289 |
| Q39668182 | Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling |
| Q91198658 | Mutation of the PTCH1 gene predicts recurrence of breast cancer |
| Q34038494 | Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland |
| Q92924437 | Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments |
| Q64246334 | Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch |
| Q26740373 | The hedgehog pathway in triple-negative breast cancer |
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