The role of Src in solid tumors

scientific article

The role of Src in solid tumors is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1634/THEONCOLOGIST.2009-0009
P3181OpenCitations bibliographic resource ID1178275
P932PMC publication ID3303596
P698PubMed publication ID19581523
P5875ResearchGate publication ID26651337

P2093author name stringDeric L Wheeler
Emily F Dunn
Mari Iida
P2860cites workCloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding geneQ24305125
Rak, a novel nuclear tyrosine kinase expressed in epithelial cellsQ24311867
Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alphaQ24328857
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesisQ24559903
Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene productQ24611377
Increase in activity and level of pp60c-src in progressive stages of human colorectal cancerQ24618378
pp60c-src activation in human colon carcinomaQ24623701
Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancerQ24803054
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutantsQ24810573
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.Q27824819
Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samplesQ28216057
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patientsQ28346761
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signalingQ28504741
Modular binding domains in signal transduction proteinsQ29617351
Regulation, substrates and functions of srcQ30014830
Src protein-tyrosine kinase structure and regulationQ30160814
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulationQ30164947
iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestineQ30193510
STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor ReceptorQ30310214
c-Src and cooperating partners in human cancerQ30434520
Src family kinases, key regulators of signal transductionQ30434839
Mechanism of biological synergy between cellular Src and epidermal growth factor receptorQ30454480
Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cellsQ30472067
A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinomaQ33376728
Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosisQ34119101
Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitisQ34124381
Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.Q34250172
Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution.Q34317180
Tyr527 is phosphorylated in pp60c-src: implications for regulationQ34383180
c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysisQ34414942
A protein tyrosine kinase involved in regulation of pp60c-src functionQ34419128
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cellsQ34460378
Activating SRC mutation in a subset of advanced human colon cancersQ34492512
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-srcQ34580219
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapyQ34674928
Alterations in the level of phosphotyrosine signal transduction constituents in human parotid tumorsQ71084428
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic miceQ71606712
Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant miceQ71706890
No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in ChineseQ73515410
Lack of activating c-SRC mutations at codon 531 in rectal cancerQ74223535
Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinomaQ74237835
Overexpression of c-Src in areas of hyperproliferation in head and neck cancer, premalignant lesions and benign mucosal disordersQ74489505
STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivoQ74649686
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximabQ81098062
Epidermal growth factor receptor expression, signal pathway, and inhibitors in non-small cell lung cancerQ34992253
Nonreceptor Protein Tyrosine Kinases Associated with Neuronal DevelopmentQ35212606
Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinomaQ35456086
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivoQ35676433
Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormonesQ35830320
The SRC-induced mesenchymal state in late-stage colon cancer cellsQ36155027
A transmissible avian neoplasm. (Sarcoma of the common fowl) by Peyton Rous, M.D., Experimental Medicine for Sept. 1, 1910, vol. 12, pp.696-705Q36342899
Treatment for advanced tumors: SRC reclaims center stageQ36420034
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activityQ36644521
The Src signaling pathway: a potential target in melanoma and other malignanciesQ36675509
CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasivenessQ36695688
Src, chemoresistance and epithelial to mesenchymal transition: are they related?Q36757204
Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell linesQ36940730
Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cellsQ37401245
src expression in small-cell lung carcinoma and other neuroendocrine malignanciesQ37900034
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cellsQ38353138
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neckQ38354192
Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signalingQ39939411
Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinomaQ39966334
Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survivalQ40158315
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cellsQ40195766
CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion.Q40211304
Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreasQ40250328
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survivalQ40272854
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cellsQ40366043
Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cellsQ40568614
Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenograftsQ40590762
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeabilityQ41714210
Analysis of the c-src gene product structure, abundance, and protein kinase activity in human neuroblastoma and glioblastoma cellsQ41820222
Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemiaQ42538832
Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.Q42820743
Inducible expression of endothelial PAS domain protein-1 by hypoxia in human lung adenocarcinoma A549 cells. Role of Src family kinases-dependent pathwayQ43829206
c-Yes tyrosine kinase activity in human colon carcinomaQ44055120
Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of huQ44441901
Natural history and functional divergence of protein tyrosine kinasesQ44646845
siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivityQ44933975
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.Q45198729
Elevated c-yes tyrosine kinase activity in premalignant lesions of the colonQ46090920
Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasivenessQ47314747
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinomaQ47375627
Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell linesQ48339399
Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas.Q52282036
Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.Q53451027
Mutation of the SRC gene in endometrial carcinoma.Q54964350
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)667-78
P577publication date2009-07-01
P1433published inOncologistQ2122327
P1476titleThe role of Src in solid tumors
P478volume14

Reverse relations

cites work (P2860)
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Q33881060The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain
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