Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

scientific article published on July 2006

Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V12.I28.4498
P932PMC publication ID4125636
P698PubMed publication ID16874861
P5875ResearchGate publication ID298736585

P50authorDaniel FourmyQ113265314
P2093author name stringAudrey Ferrand
Chantal Escrieut
Aline Kowalski-Chauvel
Catherine Seva
Claudine Bertrand
Marlene Dufresne
Sebastien Vatinel
P2860cites workSrc-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptorsQ22010243
Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptorsQ30164357
Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activationQ30168727
Molecular prognostic markers in pancreatic cancerQ34042050
Gastrins, cholecystokinins and gastrointestinal cancerQ35828198
c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitizationQ38302552
A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.Q40473455
Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism.Q40592305
Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptorQ40703003
Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptorQ40985407
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J).Q41721482
Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.Q42820743
The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.Q44936320
Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.Q46417565
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic miceQ53379866
Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia.Q53392514
Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complexQ70869135
Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptorQ73626826
Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathwayQ74643559
Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic miceQ77494291
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectpancreasQ9618
P304page(s)4498-4503
P577publication date2006-07-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleMechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas
P478volume12

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cites work (P2860)
Q35778685CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells
Q53199897Effects of cerulein on keratin 8 phosphorylation and perinuclear reorganization in pancreatic cancer cells: Involvement of downregulation of protein phosphatase 2A and alpha4.
Q39644339Loss of tyrosine phosphatase‐dependent inhibition promotes activation of tyrosine kinase c‐Src in detached pancreatic cells
Q30415151Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes
Q36115139The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules
Q24616659The role of Src in solid tumors

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