FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.

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FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1023581S
P356DOI10.1371/JOURNAL.PONE.0123581
P932PMC publication ID4430315
P698PubMed publication ID25970626
P5875ResearchGate publication ID276361621

P50authorRichard NeubigQ67330747
Benita SjögrenQ79300299
P2093author name stringSteven Swaney
P2860cites workDiversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligasesQ24306888
The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2AQ24309117
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligaseQ24316117
A gene atlas of the mouse and human protein-encoding transcriptomesQ24568043
Understanding Molecular Recognition by G protein βγ Subunits on the Path to Pharmacological TargetingQ24635233
Diversity of degradation signals in the ubiquitin-proteasome systemQ24642979
Deregulation of RGS2 in cardiovascular diseasesQ24654920
Skp1 stabilizes the conformation of F-box proteinsQ54585205
Profile of RGS expression in single rat atrial myocytesQ77368792
Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cellsQ82437098
The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.Q36436025
Ubiquitin and ubiquitin-like proteins in cancer pathogenesisQ36601000
Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancerQ36627994
The bitter end: the ubiquitin-proteasome system and cardiac dysfunctionQ36764396
A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.Q37432745
CRL4s: the CUL4-RING E3 ubiquitin ligasesQ37440298
Regulator of G-protein signaling (RGS) proteins in cancer biologyQ37533157
Regulators of G protein signaling proteins as targets for drug discovery.Q37778514
The cullin protein familyQ37873586
RGS2 suppresses breast cancer cell growth via a MCPIP1-dependent pathway.Q38960056
Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulationQ39237066
Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) ProteinsQ41470342
RGS4 is arginylated and degraded by the N-end rule pathway in vitroQ41732590
Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53.Q42722283
Regulation of RGS proteins by chronic morphine in rat locus coeruleusQ44373732
Altered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletionQ44593845
Association of RGS2 variants with panic disorder in a Japanese populationQ44964445
X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signalingQ46184056
Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?Q46214466
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophyQ46870087
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical developmentQ27643965
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical DevelopmentQ27685122
Mechanisms underlying ubiquitinationQ27860656
The ubiquitin systemQ27860803
A new subfamily of structurally related human F-box proteinsQ28207823
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cellsQ28283150
F-box proteins: the key to protein degradationQ28296039
Cellular regulation of RGS proteins: modulators and integrators of G protein signalingQ28646133
The druggable genomeQ29547361
SCF and Cullin/Ring H2-based ubiquitin ligasesQ29547637
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbationsQ30886015
Proteasome inhibitors: a novel class of potent and effective antitumor agents.Q33864458
Regulation of T cell activation, anxiety, and male aggression by RGS2.Q33920958
RGS4 and RGS5 are in vivo substrates of the N-end rule pathwayQ34085136
RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophyQ34108087
Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteinsQ34128004
Regulators of G-protein signalling as new central nervous system drug targets.Q34139169
Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.Q34144328
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient miceQ34177503
Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes StudyQ34218218
Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.Q34310119
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damageQ34353149
Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general populationQ34432231
Ubiquitin-mediated degradation of cellular proteins in health and diseaseQ34490180
Structural assembly of cullin-RING ubiquitin ligase complexesQ34762436
A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteinsQ34960765
Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouseQ35016294
Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.Q35151521
Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthmaQ35186648
Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradationQ35213523
The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extendedQ35633109
The development of proteasome inhibitors as anticancer drugsQ35773857
Regulators of G protein signaling: potential drug targets for controlling cardiovascular and immune functionQ35793755
Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levelsQ36174768
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectproteasomal protein catabolic processQ14905468
F-box protein 44Q21100961
Damage specific DNA binding protein 1Q21108214
Cullin 4BQ21112921
Arginyltransferase 1Q21116740
F-box protein 44Q21495700
Arginyltransferase 1Q21496108
Damage specific DNA binding protein 1Q21497447
Regulator of G-protein signaling 2Q21980128
Cullin 4BQ21981694
P304page(s)e0123581
P577publication date2015-05-13
P1433published inPLOS OneQ564954
P1476titleFBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex
P478volume10

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cites work (P2860)
Q30278581Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis
Q36852562Digoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury.
Q57149243G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
Q47703780Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction
Q47637709Regulating the regulators: Epigenetic, transcriptional, and post-translational regulation of RGS proteins
Q30397640The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.

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