Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

scientific article

Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI84417
P932PMC publication ID5330729
P698PubMed publication ID28248203

P50authorTerence S. DermodyQ87776424
P2093author name stringLaurie A Silva
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Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La RéunionQ27485485
Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus buddingQ27486025
Chikungunya Fever in Travelers Returning to Europe from the Indian Ocean Region, 2006Q27487088
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IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya SeverityQ27487567
Epistatic Roles of E2 Glycoprotein Mutations in Adaption of Chikungunya Virus to Aedes Albopictus and Ae. Aegypti MosquitoesQ27489379
Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune responseQ34378105
Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virusQ34391631
Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 miceQ34394530
A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.Q34415623
Evolutionary influences in arboviral diseaseQ34506254
Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expressionQ34527618
Dissemination and transmission of the E1-226V variant of chikungunya virus in Aedes albopictus are controlled at the midgut barrier levelQ34600603
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Towards antivirals against chikungunya virusQ34670977
A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistenceQ34756658
Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patientsQ34875480
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunityQ34927480
Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapesQ34977748
Aedes furcifer and other mosquitoes as vectors of chikungunya virus at Mica, northeastern Transvaal, South AfricaQ35004989
Genome-wide RNAi screen identifies novel host proteins required for alphavirus entryQ35075132
Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine designQ35109218
Case reports of neuro-Chikungunya in southern ThailandQ35131464
Specific management of post-chikungunya rheumatic disorders: a retrospective study of 159 cases in Reunion Island from 2006-2012.Q35168183
Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune responseQ35192818
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A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus InfectionQ35641902
The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activationQ35838581
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Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapyQ38118022
A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilizationQ38329445
Chikungunya triggers an autophagic process which promotes viral replicationQ38560348
Protective and Pathogenic Responses to Chikungunya Virus InfectionQ38586243
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Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virusQ38895828
How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?Q38999094
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Chikungunya virus mobilizes the apoptotic machinery to invade host cell defensesQ39649864
Functional Sindbis virus replicative complexes are formed at the plasma membraneQ39657845
Interactions between the transmembrane segments of the alphavirus E1 and E2 proteins play a role in virus budding and fusionQ39732657
Active infection of human blood monocytes by Chikungunya virus triggers an innate immune responseQ39881534
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallographyQ27666147
The alphaviruses: gene expression, replication, and evolutionQ27860954
Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severityQ28476579
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from diseaseQ28533408
Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infectionQ28539964
Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus InfectivityQ28550385
Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus InfectionQ28828878
Infection with chikungunya virus in Italy: an outbreak in a temperate regionQ29346487
Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirusQ29620003
An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical featuresQ29620004
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replicationQ30009234
US Military contributions to the global response to pandemic chikungunyaQ30224145
Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomesQ30495294
Structural evidence of glycoprotein assembly in cellular membrane compartments prior to Alphavirus buddingQ30496938
Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoproteinQ30516488
Vectors of Chikungunya virus in Senegal: current data and transmission cyclesQ30559453
Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replicationQ30814936
Random codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cellsQ31111619
Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patientsQ33375141
Clinical features and epidemiology of chikungunya infection in SingaporeQ33386006
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodiesQ33517926
Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartmentsQ33632225
Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.Q33684369
Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort studyQ33793512
Chikungunya virus envelope-specific human monoclonal antibodies with broad neutralization potencyQ33806890
Neurocognitive outcome of children exposed to perinatal mother-to-child Chikungunya virus infection: the CHIMERE cohort study on Reunion IslandQ33916134
Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218.Q33942533
Distribution of three arbovirus antibodies among monkeys (Macaca fascicularis) in the PhilippinesQ33966743
Evidence of experimental vertical transmission of emerging novel ECSA genotype of Chikungunya Virus in Aedes aegyptiQ33981774
Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary ratesQ33990566
Ribavirin therapy for Chikungunya arthritis.Q34019291
Species-specific impact of the autophagy machinery on Chikungunya virus infectionQ34036496
Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicityQ34037685
Replication cycle of chikungunya: a re-emerging arbovirusQ34042046
Chikungunya virus arthritis in adult wild-type miceQ34046030
Monoclonal Antibodies as Prophylactic and Therapeutic Agents Against Chikungunya VirusQ40077669
A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus GenotypesQ40082746
Emergence of chikungunya fever on the French side of Saint Martin island, October to December 2013.Q40210836
Chikungunya virus-like particles are more immunogenic in a lethal AG129 mouse model compared to glycoprotein E1 or E2 subunitsQ40232449
A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virusQ40245153
Chikungunya virus and the mosquito vector Aedes aegypti in New Caledonia (South Pacific Region).Q40267431
Impaired quality of life after chikungunya virus infection: a 2-year follow-up studyQ40292985
A fatal case of chikungunya virus infection with liver involvement.Q40336232
Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and SingaporeQ40372568
Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on RéunionQ40412307
A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India.Q40414131
Effects of site-directed mutations of transmembrane cysteines in sindbis virus E1 and E2 glycoproteins on palmitylation and virus replicationQ41008365
Fate of the 6K membrane protein of Semliki Forest virus during virus assemblyQ41653530
Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritisQ41857816
Chikungunya virus aches and pains: an emerging challengeQ41940293
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trialQ42199381
Chikungunya Virus in Macaques, MalaysiaQ42539696
Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemicQ42623122
Chikungunya virus infection, Brazzaville, Republic of Congo, 2011.Q42930994
FURTHER STUDIES ON THE CHIKUNGUNYA OUTBREAK IN SOUTHERN RHODESIA IN 1962. I. MOSQUITOES, WILD PRIMATES AND BIRDS IN RELATION TO THE EPIDEMIC.Q42979179
Experimental infection of Macaca radiata with Chikungunya virus and transmission of virus by mosquitoesQ42998346
Laboratory vector studies on six mosquito and one tick species with chikungunya virusQ43001737
Chikungunya-related fatality rates, Mauritius, India, and Reunion IslandQ43230235
Development of an attenuated strain of chikungunya virus for use in vaccine productionQ44523303
The Sindbis virus 6K protein can be detected in virions and is acylated with fatty acidsQ44673795
The burden of chikungunya in the PacificQ44847469
Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection.Q44849755
Systemic involvements and fatalities during Chikungunya epidemic in India, 2006.Q44850657
Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion islandQ44851009
An animal model for studying the pathogenesis of chikungunya virus infectionQ44851012
Molecular and serological diagnosis of Chikungunya virus infectionQ44851228
Immunologic interference from sequential administration of live attenuated alphavirus vaccines.Q44851631
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectChikungunya virusQ15794049
chikungunyaQ243257
P304page(s)737-749
P577publication date2017-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleChikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies
P478volume127

Reverse relations

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