HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

scientific article

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.25217
P8608Fatcat IDrelease_wokar63wyfhf5ej6ilnpwawnei
P932PMC publication ID5495571
P698PubMed publication ID28556776

P50authorMete CivelekQ37640761
Cheng-Hsiang KuoQ79915407
Nanduri R PrabhakarQ87268232
David WuQ88316635
Gökhan M MutluQ88316639
Robert B HamanakaQ90565408
Yun FangQ96230511
P2093author name stringGuohao Dai
Leah Witt
Myung-Jin Oh
Angelo Y Meliton
Recep Nigdelioglu
Matt Krause
Ru-Ting Huang
P2860cites workGene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
Regulation of hypoxia-inducible factor-1alpha by NF-kappaBQ24657260
Control of macrophage metabolism and activation by mTOR and Akt signalingQ26781587
Hypoxia-inducible factors in physiology and medicineQ27013770
Novel mechanisms of endothelial mechanotransductionQ27022880
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epitheliumQ27316863
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene listsQ28131785
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)Q28217790
Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB siteQ28286400
Role of PFKFB3-driven glycolysis in vessel sproutingQ28295875
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxiaQ28300406
Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cavaQ28576001
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Basic and therapeutic aspects of angiogenesisQ29615219
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityQ29616651
A network-based analysis of systemic inflammation in humansQ29617040
Hierarchical organization of modularity in metabolic networksQ29618451
Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.Q37642322
FOXO1 couples metabolic activity and growth state in the vascular endotheliumQ37737237
Role of endothelial cell metabolism in vessel sprouting.Q38131224
Shear stress-initiated signaling and its regulation of endothelial functionQ38215992
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesisQ39596455
2-NBDG as a fluorescent indicator for direct glucose uptake measurementQ40369331
Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.Q40471951
Linking endothelial dysfunction with endothelial cell activationQ42110536
Production of reactive oxygen species by mitochondria: central role of complex III.Q42163292
X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db miceQ42830399
Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.Q43710397
Characterization of the Ikappa B-kinase NEMO binding domainQ44147137
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesisQ46678597
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.Q51331227
Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.Q53980416
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.Q54448495
Hypoxia-Inducible Factor-1 (HIF-1)Q61645733
Endothelial Hypoxia-Inducible Factor-1α Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19aQ63915033
HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophagesQ80556743
HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscleQ30832574
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.Q31031297
Effect of mechanical stretch on HIF-1{alpha} and MMP-2 expression in capillaries isolated from overloaded skeletal muscles: laser capture microdissection studyQ33215109
A method for measuring mitochondrial mass and activityQ33383918
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
NADPH oxidases: functions and pathologies in the vasculatureQ33739287
Evolutionary conserved regulation of HIF-1β by NF-κB.Q33813506
The role of shear stress in Blood-Brain Barrier endothelial physiologyQ33898503
Shear stress, SIRT1, and vascular homeostasisQ33933093
MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.Q34067870
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectivesQ34159834
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidaseQ34264162
Exercise-mediated wall shear stress increases mitochondrial biogenesis in vascular endotheliumQ34465704
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic ForcesQ34478873
Mitochondria as signaling organelles in the vascular endotheliumQ34600173
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.Q35067820
The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation.Q35193982
Endothelial cell metabolism in normal and diseased vasculatureQ35234625
Rapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplateQ35381008
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidationQ35611252
Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow.Q36095665
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activationQ36399199
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathologyQ36439122
Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct fociQ36559213
Endothelial Cell Dysfunction and the Pathobiology of AtherosclerosisQ36602763
Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humansQ36603344
The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivoQ36964212
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.Q37233061
Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endotheliumQ37343953
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.Q37487004
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.Q37570619
Causal analysis approaches in Ingenuity Pathway AnalysisQ37592031
Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.Q37625454
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P577publication date2017-05-30
P1433published ineLifeQ2000008
P1476titleHIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium
P478volume6

Reverse relations

cites work (P2860)
Q59768163Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging
Q90567461Atheroprone flow enhances the endothelial-to-mesenchymal transition
Q50085123Beyond Impressions: How Altered Shear Stress Connects Hypoxic Signaling to Endothelial Inflammation.
Q92409363Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature
Q58797353Endothelial Cell Metabolism in Atherosclerosis
Q90043572Endothelial Cells (ECs) Metabolism: A Valuable Piece to Disentangle Cancer Biology
Q89870340Endothelial mechanobiology
Q92321956Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes
Q59807751Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics
Q92663075Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
Q49834421Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites".
Q111441864Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions
Q92378153Mechanosensing and Mechanoregulation of Endothelial Cell Functions
Q98162279OxLDL-mediated immunologic memory in endothelial cells
Q92859864PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension
Q58599881PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
Q88316641Role of Cellular Metabolism in Pulmonary Diseases
Q96817913T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
Q92072509Targeting Mechanosensitive Transcription Factors in Atherosclerosis
Q93139190Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics
Q90230779The Dual Role of Inducible Nitric Oxide Synthase in Myocardial Ischemia/Reperfusion Injury: Friend or Foe?
Q58750618The Warburg Effect in Endothelial Cells and its Potential as an Anti-angiogenic Target in Cancer

Search more.