A network-based analysis of systemic inflammation in humans

scientific article (publication date: 13 October 2005)

A network-based analysis of systemic inflammation in humans is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1010326831
P356DOI10.1038/NATURE03985
P3181OpenCitations bibliographic resource ID187811
P698PubMed publication ID16136080
P5875ResearchGate publication ID7625271

P2093author name stringTompkins RG
Davis RW
Xiao W
Moldawer LL
Baker HV
Mindrinos MN
Cobb JP
Lowry SF
Brownstein BH
Cho RJ
Richards DR
Calvano SE
Chen RO
Felciano RM
Miller-Graziano C
Tschoeke SK
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P2507corrigendum / erratumErratum: Corrigendum: A network-based analysis of systemic inflammation in humansQ58072552
P433issue7061
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
systemic inflammationQ7663815
P304page(s)1032-7
P577publication date2005-10-13
P1433published inNatureQ180445
P1476titleA network-based analysis of systemic inflammation in humans
P478volume437

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Q37149446Genome-wide transcriptome analysis of 150 cell samples
Q38296660Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.
Q37466190Genomic dissection of population substructure of Han Chinese and its implication in association studies
Q36956236Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck
Q30436233Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.
Q33743706Genomic regions that influence plasma levels of inflammatory markers in hypertensive sibships
Q33831022Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks
Q29547718Genomic responses in mouse models poorly mimic human inflammatory diseases
Q34964637Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
Q40623421Genomics and pharmacogenomics of sepsis: so close and yet so far.
Q35311560Genomics of injury: The Glue Grant experience
Q38988128Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.
Q33776168Global analysis of the eukaryotic pathways and networks regulated by Salmonella typhimurium in mouse intestinal infection in vivo
Q37269986Global changes in gene expression and synergistic interactions induced by TLR9 and TLR3
Q57810073Global expression profiling and pathway analysis in two different population groups in relation to high altitude
Q37404782Global gene expression patterns in the post-pneumonectomy lung of adult mice
Q27319445Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex
Q24672981Global topological features of cancer proteins in the human interactome
Q50071936Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium.
Q36487324HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers
Q30252313HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium
Q38706319HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification
Q33388690HIV-1 activates macrophages independent of Toll-like receptors
Q93270073HMGA1-pseudogene7 transgenic mice develop B cell lymphomas
Q37273299Harmful molecular mechanisms in sepsis
Q92219359Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
Q55554983Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis.
Q33754596Hematopoiesis and its disorders: a systems biology approach
Q37174882High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging.
Q35613820High dynamic range characterization of the trauma patient plasma proteome
Q37065085High-power femtosecond-terahertz pulse induces a wound response in mouse skin
Q35913459High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei
Q34486620Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise.
Q35161494Host responses to sepsis vary in different low-lethality murine models
Q35927969Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator
Q38304297Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases
Q37846867Human genetic susceptibility to intracellular pathogens
Q34938931Human growth is associated with distinct patterns of gene expression in evolutionarily conserved networks.
Q35247557Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS.
Q33851664Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes
Q59807396Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid
Q35107280Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
Q38412875IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS.
Q43294926ISG15 governs mitochondrial function in macrophages following vaccinia virus infection.
Q34321053Identification and validation of Ifit1 as an important innate immune bottleneck
Q30002303Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Q53544703Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses.
Q40462980Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics.
Q64890677Identification of differentially expressed genes in MG63 osteosarcoma cells with drug‑resistance by microarray analysis.
Q49412994Identification of differentially expressed genes in human breast cancer cells induced by 4-hydroxyltamoxifen and elucidation of their pathophysiological relevance and mechanisms.
Q34114194Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes
Q34519267Identification of genes whose expression is altered by obesity throughout the arterial tree.
Q51051024Identification of inflammatory bowel disease-related proteins using a reverse k-nearest neighbor search.
Q36657572Identification of innate immunity genes and pathways using a comparative genomics approach
Q47275675Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database
Q38938112Identification of microRNA as sepsis biomarker based on miRNAs regulatory network analysis
Q38962390Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line
Q37245426Identification of neuronal target genes for CCAAT/enhancer binding proteins
Q39118557Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia.
Q34264912Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients
Q30438982Identification of pediatric septic shock subclasses based on genome-wide expression profiling
Q37332611Identification of the Rock-dependent transcriptome in rodent fibroblasts
Q33712853Identification of the early VIP-regulated transcriptome and its associated, interactome in resting and activated murine CD4 T cells
Q33633046Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro
Q28082850Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches
Q33421110Identifying disease-specific genes based on their topological significance in protein networks
Q26823854Identifying novel spatiotemporal regulators of innate immunity
Q90261730Immune therapy in sepsis: Are we ready to try again?
Q33858844Immunological network signatures of cancer progression and survival
Q51462733Impact of a mechanical massage on gene expression profile and lipid mobilization in female gluteofemoral adipose tissue.
Q35159879Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis.
Q28743723Importance of correlation between gene expression levels: application to the type I interferon signature in rheumatoid arthritis
Q26825209In silico modeling: methods and applications to trauma and sepsis
Q28474971In silico simulation of corticosteroids effect on an NFkB- dependent physicochemical model of systemic inflammation
Q34091078In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes
Q35977966Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients.
Q35672031Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
Q36313986Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
Q33784887Induced sputum proteome in healthy subjects and asthmatic patients
Q37159157Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo
Q37606976Inflammation and epigenetic regulation in osteoarthritis
Q51554277Inflammation in induced sputum after aluminium oxide exposure: an experimental chamber study.
Q90168064Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses
Q35933310Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
Q40218186Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.
Q27692695Inflection points in sepsis biology: from local defense to systemic organ injury
Q98466327Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response to Helicobacter pylori Infection in Mice
Q43201052Ingenuity pathway analysis of clozapine-induced obesity.
Q30471332Ingestion-controlling network: what's language got to do with it?
Q36498232Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
Q36305612Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition
Q30484002InnateDB: facilitating systems-level analyses of the mammalian innate immune response.
Q31165480Insights from computational modeling in inflammation and acute rejection in limb transplantation
Q34436868Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis
Q30774194Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: an integrated analysis of metabolic and transcriptomic data
Q37055842Integrated approaches to uncovering transcription regulatory networks in mammalian cells
Q60922135Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation
Q26824897Integrative approaches for finding modular structure in biological networks
Q35976931Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation
Q30278644Integrative pathway genomics of lung function and airflow obstruction
Q37207041Interactions among type I and type II interferon, tumor necrosis factor, and beta-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus
Q35634220Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
Q35692077Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury
Q31155261Interleukin-6 receptor rs7529229 T/C polymorphism is associated with left main coronary artery disease phenotype in a Chinese population
Q48273918Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue
Q34197603Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice
Q36633643Intracellular signal-responsive artificial gene regulation.
Q34420404Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells
Q38796321Investigating the neuroimmunogenic architecture of schizophrenia
Q41761380Investigating the validity of current network analysis on static conglomerate networks by protein network stratification
Q33723516Is human blood a good surrogate for brain tissue in transcriptional studies?
Q37104899Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device
Q37557080KERIS: kaleidoscope of gene responses to inflammation between species
Q33993559Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.
Q34984636Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells
Q89094735Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes
Q89586763Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migration and Invasion and the Implications for the Regulation of Tumorigenesis
Q33528276Knowledge-based analysis of microarrays for the discovery of transcriptional regulation relationships
Q34544374LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding
Q36240643LPS-induced modules of co-expressed genes in equine peripheral blood mononuclear cells
Q35800407Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice.
Q37802870Large-scale protein interactome mapping: strategies and opportunities
Q48193297Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis
Q34082462Leukocyte subset-derived genomewide expression profiles in pediatric septic shock
Q91681740Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia
Q28704307Leveraging models of cell regulation and GWAS data in integrative network-based association studies
Q52998087Lies, damn lies, and statistics: the perils of the P value.
Q36070874Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling
Q24650951Lipid A modification systems in gram-negative bacteria
Q92155264Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis
Q34439268Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition
Q36890028Local sparse bump hunting reveals molecular heterogeneity of colon tumors
Q33805159Longissimus dorsi transcriptome analysis of purebred and crossbred Iberian pigs differing in muscle characteristics.
Q36392640Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients
Q27332261Low-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing cells
Q26823225Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data
Q35878417MAPT isoforms: differential transcriptional profiles related to 3R and 4R splice variants
Q33734468MYC regulation of a "poor-prognosis" metastatic cancer cell state
Q35039679Macrophage immunoregulatory pathways in tuberculosis
Q36511461Malaria tolerance--for whom the cell tolls?
Q37340565Management of neonatal sepsis by Gram-negative pathogens
Q42753051Manipulation of inflammation in ARDS: achievable goal or distant target?
Q21145361Mapping gene associations in human mitochondria using clinical disease phenotypes
Q36236245Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches
Q34274318Merging experimental data and in silico analysis: a systems-level approach to autoimmune disease and cancer.
Q38615950Meta-analysis of high-throughput datasets reveals cellular responses following hemorrhagic fever virus infection.
Q36203024Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization
Q31119681Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes.
Q64107278Metabolic gene NR4A1 as a potential therapeutic target for non-smoking female non-small cell lung cancer patients
Q37599467Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study
Q35997428Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets
Q51771549Method of regulatory network that can explore protein regulations for disease classification.
Q28390889MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model
Q99406327MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway
Q37766208MicroRNAs--regulators of signaling networks in dilated cardiomyopathy
Q34700334Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells
Q37080710Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line
Q33570300Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients
Q37642583Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage
Q35238520Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis
Q33778336Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses
Q41905411Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes.
Q37739000Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis.
Q34990992Mitochondrial dysfunction during sepsis: still more questions than answers.
Q46929110Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways
Q36443509Modeling cellular machinery through biological network comparison
Q35917642Modeling community-wide molecular networks of multicellular systems
Q34611156Modeling endotoxin-induced systemic inflammation using an indirect response approach
Q38058812Modeling physiologic variability in human endotoxemia.
Q35737359Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues
Q58732411Modulation in the microRNA repertoire is responsible for the stage-specific effects of Akt suppression on murine neuroendocrine prostate cancer
Q38295550Modulation of immune response gene expression by echinacea extracts: results of a gene array analysis
Q37078095Module-based breast cancer classification
Q34624769Modules, networks and systems medicine for understanding disease and aiding diagnosis.
Q57773503Molecular Diagnostics in Sepsis: From Bedside to Bench
Q37114392Molecular and genetic inflammation networks in major human diseases.
Q35659340Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea.
Q37663707Molecular networks for the study of TCM pharmacology.
Q40200166Molecular portrait of high productivity in recombinant NS0 cells
Q34192190Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype
Q34585151Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony
Q37419056Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks.
Q37243739Motif-specific sampling of phosphoproteomes
Q42672310Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.
Q37288384Mucosa-reparing and microbiota-balancing therapeutic effect of Bacillus subtilis alleviates dextrate sulfate sodium-induced ulcerative colitis in mice
Q23917421Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology
Q56601695Multiple effects of a short-term dexamethasone treatment in human skeletal muscle and adipose tissue
Q33924871Multiscale model for the assessment of autonomic dysfunction in human endotoxemia
Q38690754Murine Models of Sepsis and Trauma: Can We Bridge the Gap?
Q37092859NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.
Q42644858NETWORKS, BIOLOGY AND SYSTEMS ENGINEERING: A CASE STUDY IN INFLAMMATION.
Q34316790NetWalker: a contextual network analysis tool for functional genomics
Q38258734Network Medicine: New Paradigm in the -Omics Era.
Q26740527Network analysis and juvenile idiopathic arthritis (JIA): a new horizon for the understanding of disease pathogenesis and therapeutic target identification
Q26822484Network analysis: a new approach to study endocrine disorders
Q58249849Network approaches to the genetic dissection of phenotypes in animals and humans
Q33373148Network evaluation from the consistency of the graph structure with the measured data
Q29547462Network medicine: a network-based approach to human disease
Q92510086Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer
Q35118812Network representations of immune system complexity
Q35599116Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer
Q91105875Network-based Biased Tree Ensembles (NetBiTE) for Drug Sensitivity Prediction and Drug Sensitivity Biomarker Identification in Cancer
Q29616384Network-based classification of breast cancer metastasis
Q28397059Network-based identification of biomarkers coexpressed with multiple pathways
Q46132991Network-guided regression for detecting associations between DNA methylation and gene expression.
Q99576354New Agents in Development for Sepsis: Any Reason for Hope?
Q34303687New approaches to sepsis: molecular diagnostics and biomarkers.
Q79440723Nicotine exposure alters in vivo human responses to endotoxin
Q37200639Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung
Q90169385Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Q37367885Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response
Q35219825Novel regulators of the systemic response to lipopolysaccharide
Q24624194Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants
Q33636236Nr4a1 is required for fasting-induced down-regulation of Pparγ2 in white adipose tissue
Q37584566Nutrition of the critically ill - emphasis on liver and pancreas
Q36607663Nutrition of the critically ill — a 21st-century perspective.
Q34626421Of mice and men: comparative proteomics of bronchoalveolar fluid.
Q38491004On the importance of small changes in RNA expression
Q33342373Onto-CC: a web server for identifying Gene Ontology conceptual clusters
Q28291731Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
Q92509199PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells
Q38137634PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associations
Q33335133Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.
Q38980695Partitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity
Q37748077Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm
Q33762394Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences
Q33349282Pathophysiology of septic encephalopathy--an unsolved puzzle
Q40191051Pathway analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell line
Q26995884Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers
Q42161246Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival
Q38644316Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge
Q36737572Patterns of cell signaling pathway activation that characterize mammary development.
Q35131265Patterns of gene expression in peripheral blood mononuclear cells and outcomes from patients with sepsis secondary to community acquired pneumonia
Q34500398Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings.
Q33529091Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells
Q34280020Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
Q47148355Personalized physiological medicine
Q37015336Pharmacogenomics and end-organ susceptibility to injury in the perioperative period
Q37646786Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome
Q40964104Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system
Q38113306Phosphoproteomics-based network medicine.
Q34978316Physiologic variability at the verge of systemic inflammation: multiscale entropy of heart rate variability is affected by very low doses of endotoxin
Q37688169Plasma MiRNA alterations between NSCLC patients harboring Del19 and L858R EGFR mutations
Q34154148Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics
Q33319553Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram
Q40204179Platelet-derived microvesicles induce differential gene expression in monocytic cells: a DNA microarray study
Q59235075Polimorfismos del ADN mitocondrial y mortalidad en la sepsis. ¿Hemos hallado la aguja en el pajar?
Q35015398Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age
Q36953651Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
Q45231130Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates
Q30454963Potential Impact of miR-137 and Its Targets in Schizophrenia
Q61443557Potential biomarkers of acute myocardial infarction based on weighted gene co-expression network analysis
Q31142350Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
Q42152227Pre-conditioning with synthetic CpG-oligonucleotides attenuates myocardial ischemia/reperfusion injury via IL-10 up-regulation
Q36751746Prediction of disease-gene-drug relationships following a differential network analysis
Q34535852Prediction of human disease-related gene clusters by clustering analysis
Q38502201Preliminary evidence for leukocyte transcriptional signatures for pediatric ventilator-associated pneumonia.
Q36746938Presymptomatic prediction of sepsis in intensive care unit patients.
Q31158139Principal components analysis based methodology to identify differentially expressed genes in time-course microarray data
Q81028408Profiling genes in the ICU: are we there yet?
Q35850143Profiling signaling polarity in chemotactic cells.
Q40510040Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis
Q30416903Protein Cysteines Map to Functional Networks According to Steady-state Level of Oxidation
Q37125547Protein networks in disease
Q30002405Protein-protein interactions: analysis and prediction
Q35988805Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.
Q35685397Proteome from patients with metabolic syndrome is regulated by quantity and quality of dietary lipids.
Q30483815Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome
Q33512916Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling
Q36328527Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NF-κB in epicardial EMT.
Q42365502Proteomic footprint of myocardial ischemia/reperfusion injury: Longitudinal study of the at-risk and remote regions in the pig model.
Q34626049Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia
Q34082869Proteomic signatures of human oral epithelial cells in HIV-infected subjects
Q47398299Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia.
Q38266035Proteomics for systems toxicology
Q40671746Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains
Q38885740Psychiatric disorders biochemical pathways unraveled by human brain proteomics
Q36272558Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice.
Q100385859Quantitative analysis of global protein stability rates in tissues
Q35914539Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production
Q37649220Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition
Q64123698Quantitative temporal analysis of protein dynamics in cardiac remodeling
Q47341153Quantitative trait loci influencing low density lipoprotein particle size in African Americans
Q42335704RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancer
Q34530641RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia
Q21093255Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants
Q37325253Recent progress using systems biology approaches to better understand molecular mechanisms of immunity
Q42170665Refinement and expansion of signaling pathways: the osmotic response network in yeast
Q33810589Region-specific protein abundance changes in the brain of MPTP-induced Parkinson's disease mouse model
Q33280659Regulatory network of inflammation downstream of proteinase-activated receptors
Q35634129Relationships among the concentrations of 25 inflammation-associated proteins during the first postnatal weeks in the blood of infants born before the 28th week of gestation
Q33513479Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles
Q33304879Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins.
Q30539988Resolvin D2 restores neutrophil directionality and improves survival after burns
Q31066861Resources for integrative systems biology: from data through databases to networks and dynamic system models
Q36772416Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Q38470599Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study.
Q50050228Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting.
Q41622494Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies.
Q39387335Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.
Q91776383Role of neuroendocrine modulation and biochemistry in the sepsis in Piaractus mesopotamicus
Q35043680Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome
Q34438754Roles of SIRT1 in the acute and restorative phases following induction of inflammation
Q36664121Roles of heat-shock protein 70 in protecting against intestinal mucosal damage
Q35668432Ruminal Transcriptomic Analysis of Grass-Fed and Grain-Fed Angus Beef Cattle
Q39705556SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution
Q38823959SPARC overexpression alters microRNA expression profiles involved in tumor progression
Q36470840SYSTEM-WIDE MAPPING OF ACTIVATED CIRCUITRY IN EXPERIMENTAL SYSTEMIC INFLAMMATORY RESPONSE SYNDROME.
Q37129368Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells.
Q30479226Selective degradation of transcripts during meiotic maturation of mouse oocytes
Q43789576Sepsis : putting knowledge into practice
Q94947502Sepsis redefined: the search for surrogate markers
Q38453261Sepsis: a roadmap for future research
Q64112480Sepsis: evolving concepts and challenges
Q36757452Sepsis: from pattern to mechanism and back.
Q37239817Sepsis: links between pathogen sensing and organ damage
Q22255578Sepsis: rethinking the approach to clinical research
Q33695664Short- and long-term changes in gene expression mediated by the activation of TLR9
Q36973156Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis.
Q50716381Simultaneous identification of differential gene expression and connectivity in inflammation, adipogenesis and cancer.
Q101159101Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19
Q47245579Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain
Q33403099Sparse canonical methods for biological data integration: application to a cross-platform study.
Q30483613Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network
Q54445458Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis.
Q33735322Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses
Q50885568Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.
Q33551373Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses
Q90572947Structural Analysis of Hippocampal Kinase Signal Transduction
Q34340507Studying and modelling dynamic biological processes using time-series gene expression data
Q34031515Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire
Q36286867Subnetwork-based analysis of chronic lymphocytic leukemia identifies pathways that associate with disease progression
Q35027856Subventricular zone microglia transcriptional networks
Q33558619Support Vector Machines with Disease-gene-centric Network Penalty for High Dimensional Microarray Data
Q36093490Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup.
Q34400938Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis
Q92332907Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Q55366238Synthetic CpG oligonucleotides induce a genetic profile ameliorating murine myocardial I/R injury.
Q33388643Systematic identification of gene activities promoting hypoxic death
Q33325510Systemic and hepatosplanchnic macro- and microcirculatory dose response to arginine vasopressin in endotoxic rabbits
Q38006928Systemic inflammation and comorbidities in chronic obstructive pulmonary disease
Q35803664Systemic responses of preterm newborns with presumed or documented bacteraemia
Q61803767Systems Biology Approaches Toward Understanding Primary Mitochondrial Diseases
Q47585577Systems Biology: a new hope for drug discovery?
Q37029703Systems biology of circadian-immune interactions.
Q36678582Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status
Q42378630Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease
Q35739477Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite
Q64064602TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2
Q35051874TVNViewer: an interactive visualization tool for exploring networks that change over time or space
Q100490792Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells
Q37100742Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling
Q57811691TdIF1: a putative oncogene in NSCLC tumor progression
Q37032690Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells
Q33275595Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis
Q34518038Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis
Q37674614Temporal metabolic profiling of plasma during endotoxemia in humans
Q29615564Ten years of pathway analysis: current approaches and outstanding challenges
Q33885428The 'Tyranny of choices' in the ingestion-controlling network
Q35739675The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes
Q36248293The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages
Q38713172The Glue Grant experience: characterizing the post injury genomic response
Q38613269The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.
Q34673513The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Q38823800The Key Genes of Chronic Pancreatitis which Bridge Chronic Pancreatitis and Pancreatic Cancer Can be Therapeutic Targets.
Q31104394The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment
Q39216661The PARA-suite: PAR-CLIP specific sequence read simulation and processing
Q28395210The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease
Q87166150The Severity of Injury and the Extent of Hemorrhagic Shock Predict the Incidence of Infectious Complications in Trauma Patients
Q41272286The Volume of Three-Dimensional Cultures of Cancer Cells InVitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors
Q34736071The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects.
Q34772323The breadth and type of systemic inflammation and the risk of adverse neurological outcomes in extremely low gestation newborns
Q35050381The central role of AMP-kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis
Q30493853The challenges for molecular nutrition research 2: quantification of the nutritional phenotype
Q33372816The challenges for molecular nutrition research 4: the "nutritional systems biology level".
Q53222994The circadian gene CRY2 is associated with breast cancer aggressiveness possibly via epigenomic modifications.
Q35830099The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
Q33369427The evolving transcriptome of head and neck squamous cell carcinoma: a systematic review
Q28272073The histone demethylase UTX enables RB-dependent cell fate control
Q40605586The importance of early detection of endotoxemia.
Q35876790The influence of developmental age on the early transcriptomic response of children with septic shock
Q28468675The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio)
Q26823637The meta-genome of sepsis: host genetics, pathogens and the acute immune response
Q38972966The metabolic stress response to burn trauma: current understanding and therapies.
Q41197580The metabolomics of necrotising enterocolitis in preterm babies: an exploratory study.
Q34220102The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.
Q35068170The peripheral blood transcriptome reflects variations in immunity traits in swine: towards the identification of biomarkers.
Q38482642The peripheral whole-blood transcriptome of acute pyelonephritis in human pregnancya
Q35662823The proteome of Hypobaric Induced Hypoxic Lung: Insights from Temporal Proteomic Profiling for Biomarker Discovery
Q39232888The recent progress in animal models of depression.
Q38159424The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
Q39656925The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity
Q34713116The shared crosstalk of multiple pathways involved in the inflammation between rheumatoid arthritis and coronary artery disease based on a digital gene expression profile
Q36291699The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria
Q36221500The transcriptome of the fetal inflammatory response syndrome
Q24633127The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
Q37679716The use of network analyses for elucidating mechanisms in cardiovascular disease
Q36672069Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits
Q36887299Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer
Q37235089Time course of gene expression during mouse skeletal muscle hypertrophy.
Q50746534Time-course microarrays reveal modulation of developmental, lipid metabolism and immune gene networks in intrascapular brown adipose tissue during the development of diet-induced obesity.
Q30539316Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis
Q37596430Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.
Q37666053Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases
Q31054943Topology-based cancer classification and related pathway mining using microarray data
Q37166062Toward accurate reconstruction of functional protein networks
Q37087531Towards a molecular characterisation of pathological pathways.
Q30912178Toxicity mechanisms identification via gene set enrichment analysis of time-series toxicogenomics data: impact of time and concentration.
Q36673413Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection.
Q50046060Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis.
Q37147158Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy
Q36721294Transcriptional instability during evolving sepsis may limit biomarker based risk stratification
Q34995072Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia
Q33642163Transcriptional profiling of host gene expression in chicken embryo lung cells infected with laryngotracheitis virus
Q41865967Transcriptional reprogramming of metabolic pathways in critically ill patients
Q35147164Transcriptional signature of progesterone in the fathead minnow ovary (Pimephales promelas)
Q40329297Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases
Q35705783Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder
Q46127606Transcriptome analysis of mRNA and microRNAs in intramuscular fat tissues of castrated and intact male Chinese Qinchuan cattle
Q34277551Transcriptome characterization by RNA-seq unravels the mechanisms of butyrate-induced epigenomic regulation in bovine cells
Q34117785Transcriptome dynamics during human erythroid differentiation and development
Q33969250Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction.
Q34297093Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia
Q54309686Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs.
Q35177087Transcriptome responses to heat stress in hypothalamus of a meat-type chicken
Q39733187Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing
Q28386749Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity
Q36216029Transcriptomic Changes in Liver of Young Bulls Caused by Diets Low in Mineral and Protein Contents and Supplemented with n-3 Fatty Acids and Conjugated Linoleic Acid.
Q41928212Transcriptomic Sequencing Reveals a Set of Unique Genes Activated by Butyrate-Induced Histone Modification
Q33868618Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea
Q35688280Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells
Q38064340Translational applications of evaluating physiologic variability in human endotoxemia.
Q37742690Translational potential of systems-based models of inflammation
Q33330867Translational systems biology of inflammation
Q36806452Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient
Q37080009Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling
Q37637184Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.
Q36847019Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis
Q35035000Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma
Q38988559Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics
Q37668704Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels
Q50136497Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats.
Q30377576Unique ability of pandemic influenza to downregulate the genes involved in neuronal disorders.
Q37448085Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
Q53622866Unveiling differentially expressed genes upon regulation of transcription factors in sepsis.
Q36442993Update in critical care 2005.
Q21145334Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data
Q37119041Using innate immunity to characterize the host response to microbial invasion in severe sepsis
Q33828840Using systems biology to simplify complex disease: immune cartography
Q30439433Validating the genomic signature of pediatric septic shock.
Q35387550Validation of a gene expression-based subclassification strategy for pediatric septic shock.
Q34618824Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.
Q36924004Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.
Q90150895Vitamin C: an essential "stress hormone" during sepsis
Q37073220Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis
Q29540785Winning a Won Game: Caffeine Panacea for Obesity Syndemic
Q35147780Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling
Q37304831Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells
Q38621817iCAVE: an open source tool for visualizing biomolecular networks in 3D, stereoscopic 3D and immersive 3D.
Q35797478mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes.
Q36527132mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors
Q37276128microRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis
Q30540545β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury
Q34646385δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens

Q58072552Erratum: Corrigendum: A network-based analysis of systemic inflammation in humansmain subjectP921

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