Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease

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Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1194/JLR.M014092
P932PMC publication ID3137013
P698PubMed publication ID21606463

P50authorChangcheng ZhouQ43116411
P2093author name stringJan L Breslow
Nakesha King
Jinxian Xu
Brian Pridgen
P2860cites workGene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
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Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipaseQ36585001
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Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Q36943690
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PXR induces CYP27A1 and regulates cholesterol metabolism in the intestineQ40211467
Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null miceQ43181464
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Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement).Q44542257
Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitusQ44553205
Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface.Q46819707
GSEA-P: a desktop application for Gene Set Enrichment Analysis.Q51909999
Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.Q53602890
Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-α secretion in Abca1-deficient macrophagesQ57375114
Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetesQ62583515
Mouse Models of AtherosclerosisQ64357718
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceQ77231603
The burden of mortality attributable to diabetes: realistic estimates for the year 2000Q81118799
P433issue8
P921main subjecthyperglycemiaQ271993
atherosclerosisQ12252367
P304page(s)1483-1493
P577publication date2011-05-23
P1433published inJournal of Lipid ResearchQ6295449
P1476titleHyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
P478volume52

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