Liver x receptor signaling pathways and atherosclerosis

scientific article

Liver x receptor signaling pathways and atherosclerosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1161/ATVBAHA.109.191197
P932PMC publication ID2919217
P698PubMed publication ID20631351
P5875ResearchGate publication ID45188580

P50authorPeter TontonozQ62569518
Anna C CalkinQ64359190
P2860cites workSynthetic LXR ligand inhibits the development of atherosclerosis in miceQ24530617
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptorQ24656186
Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemiaQ24657127
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alphaQ24683359
Reciprocal regulation of inflammation and lipid metabolism by liver X receptorsQ28202771
An oxysterol signalling pathway mediated by the nuclear receptor LXR alphaQ28294042
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathwaysQ28512993
Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoEQ28513193
Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout miceQ28589168
Atherosclerosis. the road aheadQ29618972
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouseQ30491802
The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.Q33924208
TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.Q34145009
Identification of macrophage liver X receptors as inhibitors of atherosclerosisQ34154665
Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient miceQ36953485
Differential anti-atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317Q37145836
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosisQ37196471
T0901317, an LXR agonist, augments PKA-induced vascular cell calcificationQ37218460
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.Q37470344
Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.Q37470957
Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expressionQ38287462
Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cellsQ40197929
Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.Q40377173
Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR).Q40385609
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol MetabolismQ40622775
Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structureQ40683418
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley ratsQ41586886
Macrophage apoptosis in advanced atherosclerosisQ41851126
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophagesQ42435836
Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cellsQ43852825
Accumulation of foam cells in liver X receptor-deficient miceQ44114728
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient miceQ44314934
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteriesQ44940978
Macrophage liver X receptor is required for antiatherogenic activity of LXR agonistsQ45147987
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.Q46019644
Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient miceQ46372670
LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanismsQ46403400
7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cellsQ46499797
The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammationQ46506824
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicityQ46560187
Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosisQ46604235
The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- miceQ46626487
Laminar shear stress regulates liver X receptor in vascular endothelial cellsQ46838363
Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1Q81172881
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
P304page(s)1513-1518
P577publication date2010-08-01
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleLiver x receptor signaling pathways and atherosclerosis
P478volume30

Reverse relations

cites work (P2860)
Q374186743,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice
Q49156822A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.
Q24316186ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis
Q58123949Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1
Q37466848Activation of liver X receptor attenuates lysophosphatidylcholine-induced IL-8 expression in endothelial cells via the NF-κB pathway and SUMOylation.
Q54347900Activation of liver X receptor enhances the proliferation and migration of endothelial progenitor cells and promotes vascular repair through PI3K/Akt/eNOS signaling pathway activation.
Q36352141Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy
Q34490950Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction
Q35903298Animal models of atherosclerosis
Q26860162Anti-inflammatory therapy in chronic disease: challenges and opportunities
Q30241977Association between familial hypobetalipoproteinemia and the risk of diabetes. Is this the other side of the cholesterol-diabetes connection? A systematic review of literature
Q42121513Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease
Q89835099Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes
Q64965319Cholesterol metabolism-physiological regulation and pathophysiological deregulation by the endoplasmic reticulum.
Q37864394Control of nuclear receptor activities in metabolism by post-translational modifications
Q35917056Crosstalk between reverse cholesterol transport and innate immunity
Q37702199Current guidelines for high-density lipoprotein cholesterol in therapy and future directions.
Q33916075Decreased expression of liver X receptor-α in macrophages infected with Chlamydia pneumoniae in human atherosclerotic arteries in situ.
Q38848673Detection and treatment of atherosclerosis using nanoparticles
Q39469616Dietary ellagic acid attenuates oxidized LDL uptake and stimulates cholesterol efflux in murine macrophages
Q30412216Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading
Q45162592Discovery of Highly Potent Liver X Receptor β Agonists.
Q21285000Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery
Q40764658Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia
Q35653968Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice
Q36322805Emerging role of liver X receptors in cardiac pathophysiology and heart failure
Q34518507Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration
Q38752078Estimation of Interleukin-1β Promoter (-31 C/T and -511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients
Q37619593Eyeballing cholesterol efflux and macrophage function in disease pathogenesis
Q38099536Genetics of HDL-C: a causal link to atherosclerosis?
Q36740921Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells
Q37726678Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway
Q34440353Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development
Q35107280Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
Q41921187IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.
Q34489752Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes
Q34226831Identification of novel liver X receptor activators by structure-based modeling
Q47433840Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases.
Q58329651Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content
Q34551679Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Q38038125Inhibition of cholesterol absorption: targeting the intestine.
Q38633215Intestinal toxicity of the type B trichothecene mycotoxin fusarenon-X: whole transcriptome profiling reveals new signaling pathways
Q38631767KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility
Q58765163Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer
Q34444310LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis
Q91916968LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target
Q38570304LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.
Q54324443LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.
Q61797279Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe
Q36931267Lipid droplet-associated proteins in atherosclerosis (Review).
Q30684049Lipid metabolism emerges as a promising target for malignant glioma therapy
Q88761261Lipid metabolism reprogramming and its potential targets in cancer
Q90604280Lipid rafts as a therapeutic target
Q30426995Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
Q33553493Liver X receptor gene polymorphisms in tuberculosis: effect on susceptibility
Q36410637Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes
Q42394480Liver X receptors and atherosclerosis: it is not all cholesterol
Q28082452Liver X receptors at the intersection of lipid metabolism and atherogenesis
Q57117258Liver X receptors in lipid signalling and membrane homeostasis
Q24608256Liver x receptors in atherosclerosis and inflammation
Q36602809Macrophage Phenotype and Function in Different Stages of Atherosclerosis
Q90661189Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis
Q30371540Macrophage-independent regulation of reverse cholesterol transport by liver X receptors.
Q29617765Macrophages in the pathogenesis of atherosclerosis
Q35571915MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF
Q43849671Mitochondrial (dys)function and regulation of macrophage cholesterol efflux
Q26825337Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses
Q41482082Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and Toll-like receptor 4 activation in human macrophages.
Q38892782Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation.
Q37152902Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis
Q35679745Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis
Q38125279Molecular biology of atherosclerosis
Q35924658Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis
Q93052075New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
Q37314961New roles of HDL in inflammation and hematopoiesis
Q42674175Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway
Q49922734Non-genomic effects of nuclear receptors: insights from the anucleate platelet.
Q35165186Nuclear receptors as therapeutic targets for Alzheimer's disease
Q28079661Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome
Q28390150Nutritional lipidomics: molecular metabolism, analytics, and diagnostics
Q38133807Oxysterols and redox signaling in the pathogenesis of non-alcoholic fatty liver disease.
Q33649595Oxysterols and their cellular effectors
Q28535030Parameter trajectory analysis to identify treatment effects of pharmacological interventions
Q36987659Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages
Q38261037Practical strategies for modulating foam cell formation and behavior
Q35167931Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages
Q125637246RETRACTED ARTICLE: The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase si
Q52965346RIP140 as a novel therapeutic target in the treatment of atherosclerosis.
Q38459399Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin
Q93193771Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal
Q55311460Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages.
Q57072613Sterol Metabolism and Transport in Atherosclerosis and Cancer
Q37149077Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
Q39039098Tannerella forsythia BspA increases the risk factors for atherosclerosis in ApoE(-/-) mice
Q37457211Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1.
Q38121980Targeting SREBP-1-driven lipid metabolism to treat cancer
Q30486738The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors
Q36937104The association of NR1H3 gene with lipid deposition in the pig.
Q53615353The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects.
Q37071339The liver X receptor agonist TO901317 protects mice against cisplatin-induced kidney injury
Q33653635The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis
Q35104236The mutual interplay of lipid metabolism and the cells of the immune system in relation to atherosclerosis
Q38762998The role of dyslipidemia in diabetic retinopathy
Q37367993The role of the liver X receptor in chronic obstructive pulmonary disease
Q99616858Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis
Q33672543Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
Q42774938Transcriptome profiling reveals that the SM22α-regulated molecular pathways contribute to vascular pathology
Q38161749Tumor metabolism of malignant gliomas
Q33879659Why AMD is a disease of ageing and not of development: mechanisms and insights
Q38916069miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
Q55524753miR-33 inhibition attenuates the effect of liver X receptor agonist T0901317 on expression of liver X receptor alpha in mice liver.

Search more.