Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates

scientific article

Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/FEMSPD/FTV036
P932PMC publication ID4462183
P698PubMed publication ID25986219
P5875ResearchGate publication ID277088083

P50authorMyron M. LevineQ29564379
Stefanie N. VogelQ92126561
Leah E ColeQ123569288
P2093author name stringAiping Qin
Barbara J Mann
Araceli E Santiago
Eileen M Barry
Christen Grassel
Aimee L Cunningham
P2860cites workLive attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primatesQ27323387
Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetiQ73816633
Tularemia vaccine study. II. Respiratory challengeQ79015704
Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimerQ80197122
Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free mediaQ81445405
Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strainQ30409782
Requirement of the CXXC motif of novel Francisella infectivity potentiator protein B FipB, and FipA in virulence of F. tularensis subsp. tularensisQ30430676
Identification of an essential Francisella tularensis subsp. tularensis virulence factorQ30439303
Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulenceQ30440960
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challengeQ33346284
Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humansQ34003433
Induction of protective immunity against Chlamydia muridarum intravaginal infection with the chlamydial immunodominant antigen macrophage infectivity potentiatorQ34445366
Mucosal immunization with live attenuated Francisella novicida U112ΔiglB protects against pulmonary F. tularensis SCHU S4 in the Fischer 344 rat modelQ34464553
Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strainQ34975711
Attenuated Francisella novicida transposon mutants protect mice against wild-type challengeQ35073798
The Neisseria meningitidis macrophage infectivity potentiator protein induces cross-strain serum bactericidal activity and is a potential serogroup B vaccine candidateQ35191903
A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulenceQ35671633
In vivo negative selection screen identifies genes required for Francisella virulenceQ35699734
Molecular characterization and subcellular localization of macrophage infectivity potentiator, a Chlamydia trachomatis lipoproteinQ35879416
Type I interferon signaling is required for activation of the inflammasome during Francisella infectionQ36229342
A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. and Chlamydia trachomatis-cloning and characterization of the C. psittaci mip-like geneQ36834560
Activation of the inflammasome upon Francisella tularensis infection: interplay of innate immune pathways and virulence factors.Q36896004
Nucleotide sequence analysis of the Legionella micdadei mip gene, encoding a 30-kilodalton analog of the Legionella pneumophila Mip proteinQ36988488
Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine.Q37033153
Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophagesQ37048382
The inflammasome: a key player in the inflammation triggered in response to bacterial pathogensQ37114492
The disulfide bond formation (Dsb) systemQ37136271
Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genesQ37276296
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challengeQ37364640
DSB proteins and bacterial pathogenicity.Q37386934
Disulfide bond formation system in Escherichia coli.Q37536471
The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14.Q37858322
Molecular cloning of a Coxiella burnetii gene encoding a macrophage infectivity potentiator (Mip) analogueQ37886288
Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene productQ37895508
Protein disulfide bond generation in Escherichia coli DsbB-DsbA.Q38606615
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccinesQ39513114
Intracellular multiplication and virulence of Shigella flexneri auxotrophic mutants.Q39569905
Antibodies are generated during infection to Coxiella burnetii macrophage infectivity potentiator protein (Cb-Mip).Q40658460
Aerogenic immunization of man with live Tularemia vaccineQ40720507
Construction of genetically defined double aro mutants of Salmonella typhiQ40743402
The use of live attenuated Salmonella for oral vaccinationQ43418467
Molecular analysis of two novel Neisseria gonorrhoeae virulent components: the macrophage infectivity potentiator and the outer membrane protein A.Q43769755
Collagen binding protein Mip enables Legionella pneumophila to transmigrate through a barrier of NCI-H292 lung epithelial cells and extracellular matrixQ46300643
P433issue6
P921main subjectFrancisella tularensisQ1003460
attenuated vaccineQ1810913
P304page(s)ftv036
P577publication date2015-05-17
P1433published inPathogens and diseaseQ27724629
P1476titleCharacterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates
P478volume73

Reverse relations

cites work (P2860)
Q57805360Aerosol prime-boost vaccination provides strong protection in outbred rabbits against virulent type A Francisella tularensis
Q37438123An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy
Q40121791Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis.
Q50133614Deletion of the Major Facilitator Superfamily Transporter fptB Alters Host Cell Interactions and Attenuates Virulence of Type A Francisella tularensis
Q55070411Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis.
Q35875539Phylogenetic analysis of human Chlamydia pneumoniae strains reveals a distinct Australian indigenous clade that predates European exploration of the continent.
Q40093204Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model
Q38838074Tularemia vaccines.

Search more.