Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes

scientific article published on 03 March 2009

Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2009.02.073
P932PMC publication ID2716139
P698PubMed publication ID19368784
P5875ResearchGate publication ID24279856

P50authorMyron M. LevineQ29564379
P2093author name stringStefanie N Vogel
Araceli E Santiago
Eileen M Barry
Leah E Cole
Augusto Franco
P2860cites workThe complete genome sequence of Francisella tularensis, the causative agent of tularemiaQ22122045
A method for allelic replacement in Francisella tularensisQ40644619
Aerogenic immunization of man with live Tularemia vaccineQ40720507
AEROSOL INFECTION OF MAN WITH PASTEURELLA TULARENSISQ41008144
From rabbits to humans: the contributions of Dr. Theodore E. Woodward to tularemia researchQ43222729
Francisella tularensis selectively induces proinflammatory changes in endothelial cellsQ47677588
The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm.Q50763785
Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.Q54181225
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.Q54452752
Immunization against tularemia: analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory-acquired tularemiaQ67541973
Transformation and allelic replacement in Francisella sppQ67859396
Cytokine expression in the liver of mice infected with a highly virulent strain of Francisella tularensisQ71661744
Electroporation of Francisella tularensisQ71722151
Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2Q73419660
Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free mediaQ81445405
Identification of an essential Francisella tularensis subsp. tularensis virulence factorQ30439303
Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulenceQ30440960
Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4.Q30726013
Construction of a reporter plasmid for screening in vivo promoter activity in Francisella tularensisQ30772154
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challengeQ33346284
Rapid local expression of interleukin-12, tumor necrosis factor alpha, and gamma interferon after cutaneous Francisella tularensis infection in tularemia-immune miceQ34000875
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and releaseQ34248184
Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVSQ34601931
Tularemia: history, epidemiology, pathogen physiology, and clinical manifestationsQ34613846
Cytokine expression in the liver during the early phase of murine tularemia.Q35385119
Characterization of the nucleotide sequence of the groE operon encoding heat shock proteins chaperone-60 and -10 of Francisella tularensis and determination of the T-cell response to the proteins in individuals vaccinated with F. tularensisQ35546862
The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigensQ35689103
Virulence comparison in mice of distinct isolates of type A Francisella tularensisQ35792914
Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophagesQ35949677
Vaccination strategies for Francisella tularensisQ36140889
Type I interferon signaling is required for activation of the inflammasome during Francisella infectionQ36229342
Francisella tularensis vaccinesQ36742723
Francisella tularensis: activation of the inflammasomeQ36774974
Genetics and genetic manipulation in Francisella tularensisQ36774980
Uptake and intracellular fate of Francisella tularensis in human macrophagesQ36792201
Francisella tularensis genomics and proteomicsQ36792217
In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodiesQ36953816
Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathwaysQ37088323
An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strainQ37120769
In Vitro Interactions Between Rabbit Alveolar Macrophages and Pasteurella tularensisQ37389749
Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.Q39146446
In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.Q39654574
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cellsQ39913009
Growth of Francisella spp. in rodent macrophages.Q40151869
Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activationQ40245886
Immunologic consequences of Francisella tularensis live vaccine strain infection: role of the innate immune response in infection and immunityQ40278110
Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in miceQ40356819
Allelic exchange in Francisella tularensis using PCR productsQ40606566
Construction and characterization of a highly efficient Francisella shuttle plasmidQ40622839
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
Francisella tularensisQ1003460
attenuated vaccineQ1810913
P304page(s)2426-2436
P577publication date2009-03-03
P1433published inVaccineQ7907941
P1476titleCharacterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes
P478volume27

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cites work (P2860)
Q33801151A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection
Q57805360Aerosol prime-boost vaccination provides strong protection in outbred rabbits against virulent type A Francisella tularensis
Q57915185Attenuated Bacterial Vaccines
Q83831171BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge i
Q40121791Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis.
Q30299919Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates
Q37073234De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo
Q27674590De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans
Q50133614Deletion of the Major Facilitator Superfamily Transporter fptB Alters Host Cell Interactions and Attenuates Virulence of Type A Francisella tularensis
Q42732054Exploitation of host cell biology and evasion of immunity by francisella tularensis
Q47131278Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth.
Q30425739Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesis
Q34655078Inactivation of the Rgg2 transcriptional regulator ablates the virulence of Streptococcus pyogenes
Q55070411Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis.
Q30409782Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain
Q30222801Live attenuated tularemia vaccines: recent developments and future goals
Q30423136Members of the Francisella tularensis phagosomal transporter subfamily of major facilitator superfamily transporters are critical for pathogenesis
Q35745572Mutational Analysis of the Chlamydia muridarum Plasticity Zone
Q33615261Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling
Q30424747Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge
Q35924128Signature-tagged mutagenesis of Vibrio vulnificus.
Q27499012Systems approach to investigating host-pathogen interactions in infections with the biothreat agent Francisella. Constraints-based model of Francisella tularensis
Q30356398The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors
Q30413938The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence
Q35075784Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense
Q38838074Tularemia vaccines.
Q35095362Vaccines against tularemia
Q37451520Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development

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