The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence

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The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...993558P
P356DOI10.1371/JOURNAL.PONE.0093558
P932PMC publication ID3973589
P698PubMed publication ID24695402
P5875ResearchGate publication ID261327466

P2093author name stringGirija Ramakrishnan
Natalie Marie Pérez
P2860cites workUniversal chemical assay for the detection and determination of siderophores.Q50905929
Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporterQ74130037
Genome characterisation of the genus Francisella reveals insight into similar evolutionary paths in pathogens of mammals and fishQ21266704
TularemiaQ24535661
The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophagesQ28343891
FeoB-mediated uptake of iron by Francisella tularensisQ28675489
Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensisQ30155300
Feo--transport of ferrous iron into bacteria.Q30159790
The FupA/B protein uniquely facilitates transport of ferrous iron and siderophore-associated ferric iron across the outer membrane of Francisella tularensis live vaccine strainQ30408382
The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS.Q30432826
Characterization of the siderophore of Francisella tularensis and role of fslA in siderophore productionQ30440483
fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis Schu S4Q30440726
Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogenQ33466753
Modulation of iron homeostasis in macrophages by bacterial intracellular pathogensQ33534484
Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection modelQ33558904
EVALUATION OF LIVE TULAREMIA VACCINE PREPARED IN A CHEMICALLY DEFINED MEDIUM.Q33696706
Iron metabolism in pathogenic bacteria.Q33920195
Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infectionQ34132560
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophagesQ34145815
Iron and metal regulation in bacteriaQ34205005
Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulenceQ34294181
Role of iron in regulation of virulence genesQ34363235
The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteriaQ34415897
Iron and microbial infectionQ34650077
Identification of Francisella tularensis genes affected by iron limitationQ34721354
Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cellsQ34853708
The labile iron pool: characterization, measurement, and participation in cellular processes(1).Q34956696
Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strainQ34975711
Major role for FeoB in Campylobacter jejuni ferrous iron acquisition, gut colonization, and intracellular survivalQ35073883
Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strainQ35090016
Potential source of Francisella tularensis live vaccine strain attenuation determined by genome comparisonQ35220372
Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growthQ35403392
Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouseQ35528349
Genome-wide identification of Francisella tularensis virulence determinantsQ35913441
Iron in infection and immunityQ36913895
Live vaccine strain of Francisella tularensis: infection and immunity in miceQ36967503
The FeoC protein leads to high cellular levels of the Fe(II) transporter FeoB by preventing FtsH protease regulation of FeoB in Salmonella entericaQ37035927
FeoA and FeoC are essential components of the Vibrio cholerae ferrous iron uptake system, and FeoC interacts with FeoB.Q37253121
Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensisQ37274784
Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genesQ37276296
Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophagesQ37353316
The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of ironQ37355882
Iron metabolism: microbes, mouse, and man.Q37624574
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains.Q38606114
Disruption of mycobactin biosynthesis leads to attenuation of Mycobacterium tuberculosis for growth and virulenceQ39136936
Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of Salmonella enterica serovar TyphimuriumQ39663606
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cellsQ39913009
Characterization of the ferrous iron uptake system of Escherichia coliQ39937148
The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plagueQ41409444
Analysis of the multimer resolution system encoded by the parCBA operon of broad-host-range plasmid RP4.Q42599469
Characterization of fig operon mutants of Francisella novicida U112.Q42600585
Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesisQ45231795
The FeoA protein is necessary for the FeoB transporter to import ferrous ironQ50026110
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectFrancisella tularensisQ1003460
attenuated vaccineQ1810913
P304page(s)e93558
P577publication date2014-04-02
P1433published inPLOS OneQ564954
P1476titleThe reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence
P478volume9

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cites work (P2860)
Q38673867Bacterial ferrous iron transport: the Feo system
Q36084539Burkholderia Diffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production
Q36106837Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida
Q36439089Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis
Q30353186Iron and Virulence in Francisella tularensis.
Q89547519Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis
Q38920767Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium
Q35668833Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
Q57139247Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in virulence
Q55267074The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain.
Q30277263Two parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4
Q45072111Zinc acquisition mechanisms differ between environmental and virulent Francisella species.

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