Two parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4

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Two parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/MBO3.342
P932PMC publication ID4905997
P698PubMed publication ID26918301

P50authorGirija RamakrishnanQ91507385
P2093author name stringRichard Johnson
Bhaswati Sen
Natalie Pérez
P2860cites workGenome characterisation of the genus Francisella reveals insight into similar evolutionary paths in pathogens of mammals and fishQ21266704
Siderophore-based iron acquisition and pathogen controlQ24681774
A Hidden Markov Model method, capable of predicting and discriminating beta-barrel outer membrane proteinsQ24803433
Subversion of host recognition and defense systems by Francisella sppQ27025594
The iron metallome in eukaryotic organismsQ28109405
Evasion of IFN-γ signaling by Francisella novicida is dependent upon Francisella outer membrane protein CQ28477609
FeoB-mediated uptake of iron by Francisella tularensisQ28675489
Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensisQ30155300
PRED-TMBB: a web server for predicting the topology of beta-barrel outer membrane proteinsQ30163988
The FupA/B protein uniquely facilitates transport of ferrous iron and siderophore-associated ferric iron across the outer membrane of Francisella tularensis live vaccine strainQ30408382
The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulenceQ30413938
The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS.Q30432826
Characterization of the siderophore of Francisella tularensis and role of fslA in siderophore productionQ30440483
fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis Schu S4Q30440726
Construction and characterization of a highly efficient Francisella shuttle plasmidQ40622839
Characterization of fig operon mutants of Francisella novicida U112.Q42600585
Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonatesQ43807548
The interplay between siderophore secretion and coupled iron and copper transport in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120.Q45763521
The FeoA protein is necessary for the FeoB transporter to import ferrous ironQ50026110
Siderophore-mediated mechanism of gallium uptake demonstrated in the microorganism Ustilago sphaerogenaQ71334128
Coordination Chemistry of the Carboxylate Type Siderophore Rhizoferrin: The Iron(III) Complex and Its Metal AnalogsQ74821931
Comparative proteome analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica.Q31113818
Iron transport in Francisella in the absence of a recognizable TonB protein still requires energy generated by the proton motive forceQ33346192
Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection modelQ33558904
EVALUATION OF LIVE TULAREMIA VACCINE PREPARED IN A CHEMICALLY DEFINED MEDIUM.Q33696706
A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccineQ34194818
Whole-genome sequences of nine francisella isolatesQ34244266
Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccinationQ34291236
Role of porins in iron uptake by Mycobacterium smegmatisQ34433393
Complete Genome Sequence of Francisella endociliophora Strain FSC1006, Isolated from a Laboratory Culture of the Marine Ciliate Euplotes raikoviQ34580598
Identification of Francisella tularensis genes affected by iron limitationQ34721354
Iron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killingQ34739719
Contribution of the Shigella flexneri Sit, Iuc, and Feo iron acquisition systems to iron acquisition in vitro and in cultured cellsQ34853708
Complete Genome Sequence of Francisella guangzhouensis Strain 08HL01032T, Isolated from Air-Conditioning Systems in ChinaQ35389199
Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growthQ35403392
Mechanisms of heme utilization by Francisella tularensisQ35574562
In vivo negative selection screen identifies genes required for Francisella virulenceQ35699734
Genome-wide identification of Francisella tularensis virulence determinantsQ35913441
Copper homeostasis at the host-pathogen interfaceQ35922366
The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophilaQ35959585
The Legionella pneumophila Siderophore Legiobactin Is a Polycarboxylate That Is Identical in Structure to RhizoferrinQ36053556
Mechanisms of Francisella tularensis intracellular pathogenesisQ36933178
The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicityQ37208556
FeoA and FeoC are essential components of the Vibrio cholerae ferrous iron uptake system, and FeoC interacts with FeoB.Q37253121
Porins increase copper susceptibility of Mycobacterium tuberculosisQ37264105
Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensisQ37274784
Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophagesQ37353316
The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of ironQ37355882
Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye viewQ37769428
The struggle for iron - a metal at the host-pathogen interface.Q37801985
Highly reactive oxygen species: detection, formation, and possible functions.Q37870856
Iron speciation in the cytosol: an overviewQ38066761
Microbial quest for food in vivo: 'nutritional virulence' as an emerging paradigmQ38089379
A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112.Q38297913
Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system.Q38607194
P433issue3
P921main subjectFrancisella tularensisQ1003460
P304page(s)453-468
P577publication date2016-02-25
P1433published inMicrobiologyOpenQ27724394
P1476titleTwo parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4
P478volume5

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cites work (P2860)
Q58709793Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus
Q90375729Iron Acquisition by Bacterial Pathogens: Beyond tris-Catecholate Complexes
Q30353186Iron and Virulence in Francisella tularensis.
Q38920767Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium
Q55267074The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain.
Q47417123The Multiple Localized Glyceraldehyde-3-Phosphate Dehydrogenase Contributes to the Attenuation of the Francisella tularensis dsbA Deletion Mutant.
Q57751873Toward a mechanistic understanding of Feo-mediated ferrous iron uptake

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