The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

scientific article

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2000PNAS...97.1252D
P356DOI10.1073/PNAS.97.3.1252
P3181OpenCitations bibliographic resource ID1186039
P932PMC publication ID15586
P698PubMed publication ID10655517
P5875ResearchGate publication ID12658324

P50authorKerry RutterQ60917733
P2093author name stringY Zhu
H Su
B G Schroeder
C E Barry
J J De Voss
P2860cites workExochelin genes in Mycobacterium smegmatis: identification of an ABC transporter and two non-ribosomal peptide synthetase genesQ48027677
Universal chemical assay for the detection and determination of siderophores.Q50905929
The adverse effect of iron repletion on the course of certain infectionsQ54956692
The occurrence of carboxymycobactin, the siderophore of pathogenic mycobacteria, as a second extracellular siderophore in Mycobacterium smegmatisQ71519595
Transformation of mycobacterial species using hygromycin resistance as selectable markerQ72372996
Determination of the structure of exochelin MN, the extracellular siderophore from Mycobacterium neoaurumQ73909517
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactinQ28486708
The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophagesQ28486738
Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosisQ28486917
Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial alpha-crystallin homologQ28487133
The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2Q28487181
Characterization of exochelins of the Mycobacterium bovis type strain and BCG substrainsQ30656128
Iron acquisition and metabolism by mycobacteriaQ33635173
Analysis of the exochelin locus in Mycobacterium smegmatis: biosynthesis genes have homology with genes of the peptide synthetase familyQ33736702
Assessment of immunity to mycobacterial infection with luciferase reporter constructs.Q34001753
Modular Peptide Synthetases Involved in Nonribosomal Peptide SynthesisQ34114738
The effect of p-aminosalicyclic acid on iron transport and assimilation in mycobacteriaQ34646733
Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wallQ34662814
Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccineQ36361980
Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosisQ36602879
Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosisQ36603027
Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosisQ36830155
Iron and susceptibility to infectious diseaseQ39940354
A rapid and gentle method for the isolation of genomic DNA from mycobacteriaQ40407373
Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approachesQ40552842
Role of mycobactin in the growth and virulence of tubercle bacilliQ40878947
Extracellular iron acquisition by mycobacteria: role of the exochelins and evidence against the participation of mycobactinQ40881876
The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestisQ41485275
Microbial iron transport: iron acquisition by pathogenic microorganismsQ41691203
Bacterial iron transport: mechanisms, genetics, and regulation.Q41691207
Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatisQ41959357
Tuberculosis and iron overload in Africa: a review.Q46697838
Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosaQ48003026
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
macrophageQ184204
P304page(s)1252-7
P577publication date2000-02-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
P478volume97

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cites work (P2860)
Q284847644'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo
Q35889537A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases
Q30672146A Hidden Markov Model for identifying essential and growth-defect regions in bacterial genomes from transposon insertion sequencing data
Q36950010A Replication-Limited Recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG.
Q52663859A comparison of Rv0559c and Rv0560c expression in drug-resistant Mycobacterium tuberculosis in response to first-line antituberculosis drugs.
Q27700114A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket
Q28487138A genetic locus required for iron acquisition in Mycobacterium tuberculosis
Q33965669A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis
Q33940962A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction.
Q60914335A low-carb diet for a high-octane pathogen
Q33283240A mechanism-based aryl carrier protein/thiolation domain affinity probe
Q44130148A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.
Q35163364A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis
Q90264836A reevaluation of iron binding by Mycobactin J
Q33503444A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
Q37257062Adenylating enzymes in Mycobacterium tuberculosis as drug targets
Q35052626Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity
Q52934669Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis.
Q35608100An unprecedented NADPH domain conformation in lysine monooxygenase NbtG provides insights into uncoupling of oxygen consumption from substrate hydroxylation
Q34263643Analyses of MbtB, MbtE, and MbtF suggest revisions to the mycobactin biosynthesis pathway in Mycobacterium tuberculosis
Q38830420Antibiotic resistance mechanisms in M. tuberculosis: an update
Q37499317Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity
Q41912333Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes
Q57617771Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: analysis of the contribution of functional groups and of chelator's combination with ethambutol
Q28487064Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain
Q33994536Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases
Q91790499Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB
Q37051347BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis
Q37675898Bacterial manipulation of innate immunity to promote infection.
Q36797634Biogenetic diversity of cyanobacterial metabolites
Q46157158Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.
Q38195645Biosynthesis of mycobacterial lipids by polyketide synthases and beyond
Q27675807Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis
Q34033807Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis
Q37273190CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids
Q40447683Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis.
Q28487459Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc
Q35073550Characterization of a novel plasmid, pMAH135, from Mycobacterium avium subsp. hominissuis
Q34127364Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter
Q34028103Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis
Q58697032Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity
Q30410820Comparative analyses of transport proteins encoded within the genomes of Mycobacterium tuberculosis and Mycobacterium leprae
Q37550518Comparative genome analyses of Mycobacterium avium reveal genomic features of its subspecies and strains that cause progression of pulmonary disease
Q35775243Comparative genomics between human and animal associated subspecies of the Mycobacterium avium complex: a basis for pathogenicity
Q34734487Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria
Q53072956Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.
Q36314798Control of cell wall assembly by a histone-like protein in Mycobacteria
Q33832359Conversion of Mycobacterium smegmatis to a pathogenic phenotype via passage of epithelial cells during macrophage infection
Q42048353Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis
Q42411754Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.
Q28487128CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis
Q34880579Curation, integration and visualization of bacterial virulence factors in PATRIC
Q33636507Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy
Q36681712Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.
Q39955278Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins.
Q37000848Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents
Q33752240Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis
Q36335811Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis
Q57067336Dibasic Derivatives of Phenylcarbamic Acid against Mycobacterial Strains: Old Drugs and New Tricks?
Q91772570Differential determinants of virulence in two Mycobacterium tuberculosis Colombian clinical isolates of the LAM09 family
Q33716960Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients
Q57816272Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Q27676547Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
Q39136936Disruption of mycobactin biosynthesis leads to attenuation of Mycobacterium tuberculosis for growth and virulence
Q34128847Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice
Q90484104Diverse Localization and Protein Binding Abilities of Glyceraldehyde-3-Phosphate Dehydrogenase in Pathogenic Bacteria: The Key to its Multifunctionality?
Q92659581Dual RNA-Seq of Mtb-Infected Macrophages In Vivo Reveals Ontologically Distinct Host-Pathogen Interactions
Q39612553Effect of entF deletion on iron acquisition and erythritol metabolism by Brucella abortus 2308.
Q41927049Enabling faster Go/No-Go decisions through secondary screens in anti-mycobacterial drug discovery
Q34622456Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.
Q37257887Experimental tuberculosis: the role of comparative pathology in the discovery of improved tuberculosis treatment strategies
Q51838999Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress.
Q36314197Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum
Q89820535Functional Genomics Insights Into the Pathogenicity, Habitat Fitness, and Mechanisms Modifying Plant Development of Rhodococcus sp. PBTS1 and PBTS2
Q36934583Functions and importance of mycobacterial extracellular vesicles
Q35830969Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds
Q43077484Genome sequencing of pathogenic Rhodococcus spp.
Q60933768Genotypic differences between strains of the opportunistic pathogen Corynebacterium bovis isolated from humans, cows, and rodents
Q60914347Getting the iron out
Q99625046Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection
Q92668628Heterogeneity in respiratory electron transfer and adaptive iron utilization in a bacterial biofilm
Q87412319Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63-161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis
Q92059250Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis
Q37515880IdeR is required for iron homeostasis and virulence in Mycobacterium tuberculosis
Q28486979Identification and characterization of a major cell wall-associated iron-regulated envelope protein (Irep-28) in Mycobacterium tuberculosis
Q36948605Identification of Quantitative Proteomic Differences between Mycobacterium tuberculosis Lineages with Altered Virulence
Q28486535Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis
Q34484222Identification of nocobactin NA biosynthetic gene clusters in Nocardia farcinica
Q54345232Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.
Q28486472Identification of the Mycobacterium tuberculosis SUF machinery as the exclusive mycobacterial system of [Fe-S] cluster assembly: evidence for its implication in the pathogen's survival
Q34221919Immune interference in Mycobacterium tuberculosis intracellular iron acquisition through siderocalin recognition of carboxymycobactins
Q34332652Immune responses to intracellular bacteria.
Q61449782Immunity to the Dual Threat of Silica Exposure and
Q40763880Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections
Q47733388In vitro and intra-macrophage gene expression by Rhodococcus equi strain 103.
Q34095054In vivo veritas: the search for TB drug targets goes live
Q33565674Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine
Q27662071Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)
Q34495944Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High‐Throughput Screening
Q35378227Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis
Q92899062Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA
Q34102811Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance
Q30494299Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
Q36580730Intracellular innate resistance to bacterial pathogens.
Q36358981Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis
Q90559084IroT/MavN Is a Legionella Transmembrane Fe(II) Transporter: Metal Selectivity and Translocation Kinetics Revealed by in Vitro Real-Time Transport
Q38606667Iron Acquisition Mechanisms: Promising Target Against Mycobacterium tuberculosis
Q39601233Iron Acquisition in Mycobacterium avium subsp. paratuberculosis.
Q30804236Iron Homeostasis in Mycobacterium tuberculosis: Mechanistic Insights into Siderophore-Mediated Iron Uptake
Q92163260Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?
Q33635173Iron acquisition and metabolism by mycobacteria
Q38337798Iron acquisition strategies in mycobacteria.
Q36631531Iron acquisition within host cells and the pathogenicity of Leishmania
Q34134803Iron and Mycobacterium tuberculosis infection
Q35022961Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes
Q38387424Iron homeostasis and progression to pulmonary tuberculosis disease among household contacts
Q36913895Iron in infection and immunity
Q37376232Iron in intracellular infection: to provide or to deprive?
Q26860448Iron metabolism and the innate immune response to infection
Q46579770Iron modulates the replication of virulent Mycobacterium bovis in resting and activated bovine and possum macrophages.
Q35605944Iron, mycobacteria and tuberculosis
Q39017192Iron-regulated protein HupB of Mycobacterium tuberculosis positively regulates siderophore biosynthesis and is essential for growth in macrophages
Q43509450Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis.
Q90737097Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents
Q42927455Knocking out salicylate biosynthesis genes in Mycobacterium smegmatis induces hypersensitivity to p-aminosalicylate (PAS)
Q28216197Life and death in a macrophage: role of the glyoxylate cycle in virulence
Q34007415Life on the inside: probing mycobacterium tuberculosis gene expression during infection
Q28486753Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester
Q28545076Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis
Q35709328Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis
Q92704112Looking beyond Typical Treatments for Atypical Mycobacteria
Q41430032M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates
Q42322422Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis
Q22122381Massive gene decay in the leprosy bacillus
Q36078970MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth
Q90223256Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities
Q37201260Mechanism and regulation of mycobactin fatty acyl-AMP ligase FadD33
Q28487185Mechanistic analysis of Mycobacterium tuberculosis Rv1347c, a lysine Nepsilon-acyltransferase involved in mycobactin biosynthesis
Q28478251Metabolic regulation of mycobacterial growth and antibiotic sensitivity
Q28487095Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes
Q38935075MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria
Q41376285Models for antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines.
Q43796053Molecular approaches to tuberculosis
Q24296184Molecular mechanism of lipopeptide presentation by CD1a
Q35622988Molecular mechanisms of host-pathogen interaction: entry and survival of mycobacteria in macrophages.
Q38725050Mutational and phylogenetic analyses of the mycobacterial mbt gene cluster
Q35907046Mycobacteria, metals, and the macrophage
Q28487139Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
Q35564117Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
Q55215619Mycobacterium abscessus subsp. massiliense mycma_0076 and mycma_0077 Genes Code for Ferritins That Are Modulated by Iron Concentration.
Q34125243Mycobacterium avium genes expressed during growth in human macrophages detected by selective capture of transcribed sequences (SCOTS).
Q33975716Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine
Q35247912Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia
Q33774924Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin.
Q51122851Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
Q35145130Mycobacterium tuberculosis Rv3402c enhances mycobacterial survival within macrophages and modulates the host pro-inflammatory cytokines production via NF-kappa B/ERK/p38 signaling
Q35220629Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis
Q34435468Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin
Q34740822Mycobacterium tuberculosis can utilize heme as an iron source
Q28082718Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance
Q35145725Mycobacterium tuberculosis gene expression in macrophages
Q34137695Mycobacterium tuberculosis in the post-genomic age.
Q34213787Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence
Q82241804Mycobactin-mediated iron acquisition within macrophages
Q64273818Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria
Q33808523N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines
Q36200942Natural products as mediators of disease.
Q61858045New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies
Q91795842New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis
Q37150326New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections
Q64071213New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents
Q36752164Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii
Q27007035Nonclassical T cells and their antigens in tuberculosis
Q34596427Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
Q38397331Nucleoside analogs and tuberculosis: new weapons against an old enemy.
Q28487515One-step purification of 5-enolpyruvylshikimate-3-phosphate synthase enzyme from Mycobacterium tuberculosis
Q36558841Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein
Q53928435Partial genome sequencing of Rhodococcus equi ATCC 33701.
Q34675486Participation of fad and mbt genes in synthesis of mycobactin in Mycobacterium smegmatis
Q37263859Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Q46954996Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis
Q28476108Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo
Q40561516Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.
Q51712137Predictive models for nucleoside bisubstrate analogs as inhibitors of siderophore biosynthesis in Mycobacterium tuberculosis: pharmacophore mapping and chemometric QSAR study.
Q37256486Purification of Legiobactin and importance of this siderophore in lung infection by Legionella pneumophila
Q42836641Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis
Q35589896Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents
Q35753354Recent advances towards identification of new drug targets for Mycobacterium tuberculosis
Q28486886Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis
Q34513719Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.
Q37065759Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis
Q37643409Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition
Q35805487Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice
Q57038543Rule-based modelling of iron homeostasis in tuberculosis
Q43736212SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans
Q33894015Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates
Q37571317Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling
Q36498319Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
Q44258710Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India
Q33658322Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages
Q24681774Siderophore-based iron acquisition and pathogen control
Q90739257Signaling Natural Products from Human Pathogenic Bacteria
Q30524145Single-cell elemental analysis of bacteria: quantitative analysis of polyphosphates in Mycobacterium tuberculosis
Q34211472Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle
Q37196170Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy
Q39255222Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis
Q34483911Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
Q27661119Solution structure of Rv2377c-founding member of the MbtH-like protein family
Q36341884Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis
Q37055581Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae
Q28487072Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase
Q78232480Structure and Biosynthesis of Fimsbactins A-F, Siderophores fromAcinetobacter baumanniiandAcinetobacter baylyi
Q34916276Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium
Q27684461Structure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of Mycobacteria
Q33746313Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters
Q37062702Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans
Q35546031Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis.
Q36603702Syntheses and Biological Evaluations of Highly Functionalized Hydroxamate Containing and N-Methylthio Monobactams as Anti-Tuberculosis and β-Lactamase Inhibitory Agents
Q35650399Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis
Q36351333Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis
Q36341699Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis
Q34143574Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers
Q34459862Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.
Q48139536Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol
Q37137597Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis
Q37375735Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures
Q91971713The ABC exporter IrtAB imports and reduces mycobacterial siderophores
Q28607074The Complete Genome Sequence of the Emerging Pathogen Mycobacterium haemophilum Explains Its Unique Culture Requirements
Q89104000The Impact of Dietary Transition Metals on Host-Bacterial Interactions
Q28487578The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages
Q36159650The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
Q31114739The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M.
Q42373929The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages
Q28487146The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis
Q38200693The exochelins of pathogenic mycobacteria: unique, highly potent, lipid- and water-soluble hexadentate iron chelators with multiple potential therapeutic uses
Q45091061The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in mice
Q33455648The genetic requirements for fast and slow growth in mycobacteria
Q36396908The hydroxamate siderophore rhequichelin is required for virulence of the pathogenic actinomycete Rhodococcus equi
Q38449680The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis
Q33788460The iron-regulated iupABC operon is required for saprophytic growth of the intracellular pathogen Rhodococcus equi at low iron concentrations
Q34266438The many faces of host responses to tuberculosis
Q37117205The nature of extracellular iron influences iron acquisition by Mycobacterium tuberculosis residing within human macrophages
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Q57808855Tuning the Anti(myco)bacterial Activity of 3-Hydroxy-4-pyridinone Chelators through Fluorophores
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Q90914855Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease
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Q31156691Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses
Q28486874ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response
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Q28486582p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis

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