Regulation of T-cell Tolerance by Lymphatic Endothelial Cells.

scientific article

Regulation of T-cell Tolerance by Lymphatic Endothelial Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4172/2155-9899.1000242
P932PMC publication ID4286360
P698PubMed publication ID25580369
P5875ResearchGate publication ID270910621

P50authorVictor H EngelhardQ56930239
Jacob D EcclesQ84370292
P2093author name stringEric F Tewalt
Sherin J Rouhani
P2860cites workAire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.Q53253030
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for toleranceQ56701390
Distinct Requirements for Deletion versus Anergy during CD8 T Cell Peripheral Tolerance In VivoQ61140313
Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environmentQ61654360
Control of neonatal tolerance to tissue antigens by peripheral T cell traffickingQ77544864
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancerQ83171820
Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferationQ83766820
VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphaticsQ84621185
Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migrationQ84764268
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetesQ24323734
Chromosomal clustering of genes controlled by the aire transcription factorQ24527311
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egressQ24650866
Deletional tolerance mediated by extrathymic Aire-expressing cellsQ24652952
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cellsQ24653129
The induction of tolerance by dendritic cells that have captured apoptotic cellsQ24671078
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clonesQ28209894
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cellsQ28593219
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central toleranceQ28593303
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumabQ29620596
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoQ30080006
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapyQ30305530
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironmentQ30414892
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cellsQ30415907
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentationQ30434547
Strategies and challenges in eliciting immunity to melanomaQ30435893
Immunity to melanoma antigens: from self-tolerance to immunotherapyQ30440584
Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodesQ30444006
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.Q30471822
Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cellsQ30488797
B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.Q30490219
Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure.Q30497556
Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell toleranceQ30579730
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterningQ33615222
Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cellsQ33630143
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulationQ33756678
Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditionsQ33794995
Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell developmentQ33892077
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivoQ33924186
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4.Q33991279
Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculatureQ34007272
Regulation of T cell priming by lymphoid stroma.Q34081396
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceQ34112986
ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and plateletsQ34152157
Control of central and peripheral tolerance by AireQ34177944
Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouseQ34568929
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigensQ34572972
The enemy within: keeping self-reactive T cells at bay in the peripheryQ34573771
Control of dendritic cell trafficking in lymphatics by chemokinesQ38162731
Inflammation-induced lymphangiogenesis and lymphatic dysfunctionQ38180632
Inflammatory lymphangiogenesis: cellular mediators and functional implicationsQ38180633
Programmed death-1 pathway in cancer and autoimmunity.Q38208078
Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitroQ38305668
The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph nodeQ38459394
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymusQ38466522
Genes regulating lymphangiogenesis control venous valve formation and maintenance in miceQ39367542
Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanismQ39984665
Human lymphatic endothelial cells express multiple functional TLRs.Q40010175
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organsQ40307375
Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo.Q40465196
Conduits mediate transport of low-molecular-weight antigen to lymph node folliclesQ41291427
Culturing purifies murine lymph node lymphatic endotheliumQ41889750
T-cell tolerance: central and peripheralQ41942006
The thymic medulla: a unique microenvironment for intercellular self-antigen transferQ42572856
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunityQ43591261
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinusesQ43746398
The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factorQ47714540
Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice.Q50493740
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.Q51734752
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergyQ34575119
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cellsQ34576335
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cellsQ34578170
Dendritic cell control of tolerogenic responsesQ34982085
Cytokine control of memory T-cell development and survivalQ35096181
Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cellsQ35927606
A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivoQ35927784
Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selectionQ35974300
Tissue expression of PD-L1 mediates peripheral T cell tolerance.Q36228541
Regulation of MHC class II gene expression by the class II transactivatorQ36274925
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Q36275699
Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodesQ36278300
Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortexQ36368559
Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.Q36370873
Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen.Q36376340
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanismQ36392973
Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigensQ36400803
CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cellsQ36400881
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levelsQ36402949
Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3.Q36706765
Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockadeQ36927966
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedQ36949091
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopeniaQ37037485
Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunityQ37273185
The conduit system of the lymph nodeQ37282105
Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragmQ37362124
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction.Q37399004
Mechanisms of lymphatic metastasisQ37609660
Integrin α9 on lymphatic endothelial cells regulates lymphocyte egressQ37612652
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainageQ37635188
IL-7-producing stromal cells are critical for lymph node remodelingQ37635206
Heterogeneity and plasticity of lymphatic endothelial cellsQ37758600
Intravital two-photon microscopy of lymphatic vessel development and function using a transgenic Prox1 promoter-directed mOrange2 reporter mouseQ37958952
The inflammatory response of lymphatic endotheliumQ38155100
P921main subjectendotheliumQ111140
P577publication date2014-01-01
P1433published inJournal of Clinical & Cellular ImmunologyQ27723807
P1476titleRegulation of T-cell Tolerance by Lymphatic Endothelial Cells
P478volume5

Reverse relations

cites work (P2860)
Q49679692Defining the role of the tumor vasculature in antitumor immunity and immunotherapy
Q64060930Dendritic Cells and T Cells Interact Within Murine Afferent Lymphatic Capillaries
Q40994197Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
Q46193795Lymphatic Dysfunction, Leukotrienes, and Lymphedema.
Q89620141Lymphatic Vasculature in Energy Homeostasis and Obesity
Q37457544Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation
Q60932996Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes
Q26781338Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications
Q90185635Role of lymph node stroma and microenvironment in T cell tolerance
Q35902446Stepchild or Prodigy? Neuroprotection in Multiple Sclerosis (MS) Research
Q64248056The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells
Q41340368The Lymphatic System: Integral Roles in Immunity
Q41687685Tumor Regulation of Lymph Node Lymphatic Sinus Growth and Lymph Flow in Mice and in Humans

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