review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1021/NP990549F |
P698 | PubMed publication ID | 10650103 |
P2093 | author name string | Hecht SM | |
P2860 | cites work | Zorbamycin and related antibiotics. I. Production, isolation and characterization | Q44997509 |
THE CHEMISTRY OF BLEOMYCIN. IX | Q78418342 | ||
Chemistry of bleomycin. XXVII. Cleomycin, a new family of bleomycin-phleomycin group. | Q78419181 | ||
P433 | issue | 1 | |
P304 | page(s) | 158-168 | |
P577 | publication date | 2000-01-01 | |
P1433 | published in | Journal of Natural Products | Q165584 |
P1476 | title | Bleomycin: new perspectives on the mechanism of action | |
P478 | volume | 63 |
Q92731028 | A Novel Method for Controlled Gene Expression via Combined Bleomycin and Plasmid DNA Electrotransfer |
Q36029831 | A comprehensive review of glycosylated bacterial natural products. |
Q35567329 | A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases |
Q38457687 | A designer bleomycin with significantly improved DNA cleavage activity. |
Q34282766 | A short DNA sequence confers strong bleomycin binding to hairpin DNAs |
Q28475434 | A systematic proteomic study of irradiated DNA repair deficient Nbn-mice |
Q34587921 | A versatile and efficient gene-targeting system for Aspergillus nidulans. |
Q46690641 | Adaptive response in mice exposed to 900 MHZ radiofrequency fields: bleomycin-induced DNA and oxidative damage/repair |
Q28475489 | Adenovirus dodecahedron, as a drug delivery vector |
Q41139723 | Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung. |
Q24647468 | An SOS-regulated type 2 toxin-antitoxin system |
Q34452700 | Antibody targeted therapeutics for lymphoma: new focus on the CD22 antigen and RNA. |
Q89568332 | Anticancer therapy and lung injury: molecular mechanisms |
Q27693195 | Antimicrobial-induced DNA damage and genomic instability in microbial pathogens |
Q55309854 | Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer. |
Q38787754 | Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin |
Q92997577 | Autophagy: A Player in response to Oxidative Stress and DNA Damage |
Q43019654 | Biosynthetic mechanism for L-Gulose in main polar lipids of Thermoplasma acidophilum and possible resemblance to plant ascorbic acid biosynthesis |
Q38938411 | Bleomycin-induced trans lipid formation in cell membranes and in liposome models |
Q36026763 | Bleomycins: towards better therapeutics |
Q34502778 | BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin |
Q37408146 | C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy |
Q33404839 | Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates. |
Q52580803 | Chalkophores. |
Q41990692 | Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae |
Q41868118 | Characterization of bleomycin-mediated cleavage of a hairpin DNA library. |
Q36101371 | Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity. |
Q34495096 | Colibactin: understanding an elusive gut bacterial genotoxin |
Q41952431 | Colloidal Gold-Mediated Delivery of Bleomycin for Improved Outcome in Chemotherapy. |
Q36734563 | Comparison of high-spin and low-spin nonheme Fe(III)-OOH complexes in O-O bond homolysis and H-atom abstraction reactivities |
Q38126753 | Contributions of NMR to the understanding of the coordination chemistry and DNA interactions of metallo-bleomycins. |
Q34499818 | Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892 |
Q46572537 | DNA damage is a late event in resveratrol-mediated inhibition of Escherichia coli |
Q30310621 | DNA damaging activity of ellagic acid derivatives |
Q35651286 | DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts |
Q43090961 | DNA interactions and promotion in antibacterial activities of ciprofloxacin drug due to formation of mixed-ligand complexes of oxovanadium(IV). |
Q41890596 | DNA methylation reduces binding and cleavage by bleomycin |
Q48170538 | DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products |
Q34450286 | Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods |
Q41937604 | Design, synthesis and DNA interaction study of new potential DNA bis-intercalators based on glucuronic acid |
Q92414030 | Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3]propellane derivatives: Potential anticancer agents |
Q51742531 | Different Cell Viability Assays Reveal Inconsistent Results After Bleomycin Electrotransfer In Vitro. |
Q49379499 | Differential action of polyunsaturated fatty acids and eicosanoids on bleomycin-induced cytotoxicity to neuroblastoma cells and lymphocytes |
Q55254148 | Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues. |
Q53581809 | Double strand DNA cleavage with a binuclear iron complex. |
Q34571023 | Drugs, their targets and the nature and number of drug targets |
Q37343312 | Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA. |
Q64232727 | Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts |
Q38429124 | Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin. |
Q35028595 | Engineered proteins detect spontaneous DNA breakage in human and bacterial cells |
Q24650698 | Expedient synthesis of threo-beta-hydroxy-alpha-amino acid derivatives: phenylalanine, tyrosine, histidine, and tryptophan |
Q27687259 | From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials |
Q34864759 | Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog |
Q37136721 | Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway |
Q54468515 | Functional classification of drugs by properties of their pairwise interactions. |
Q36869783 | Further insights into the mechanism of the reaction of activated bleomycin with DNA |
Q33555099 | Genetic analysis of the Sinorhizobium meliloti BacA protein: differential effects of mutations on phenotypes. |
Q36965979 | Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation |
Q39365851 | Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy |
Q50091965 | Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1. |
Q38954561 | Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks |
Q55439551 | Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py. |
Q36940467 | In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway |
Q24813764 | Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury |
Q41813585 | Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth |
Q47983735 | Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin |
Q34119230 | Ligand exchange and spin state equilibria of Fe(II)(N4Py) and related complexes in aqueous media |
Q26822491 | Local tumour ablative therapies: opportunities for maximising immune engagement and activation |
Q78518774 | Manganese(II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA |
Q37099799 | Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells |
Q50049967 | Mechanisms and physiological effects of protamine resistance in Salmonella enterica serovar Typhimurium LT2. |
Q36928779 | Mesenchymal stem cells are sensitive to bleomycin treatment. |
Q55456470 | Metal-mediated diradical tuning for DNA replication arrest via template strand scission. |
Q34348160 | Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships |
Q38610456 | Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades |
Q34463923 | Modified bleomycin disaccharides exhibiting improved tumor cell targeting |
Q42958439 | Mononuclear Fe(II)-N4Py complexes in oxidative DNA cleavage: structure, activity and mechanism |
Q53425444 | Multinuclear non-heme iron complexes for double-strand DNA cleavage. |
Q39134299 | N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549). |
Q94526339 | NEK10 interactome and depletion reveal new roles in mitochondria |
Q37814157 | Natural glycoconjugates with antitumor activity |
Q39146488 | New modulated design and synthesis of quercetin-Cu(II)/Zn(II)-Sn2(IV) scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity |
Q54430922 | Nitrate signaling by the regulatory gene NIT2 in Chlamydomonas. |
Q35707736 | Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator. |
Q35090396 | Nonribosomal peptide synthetases involved in the production of medically relevant natural products |
Q42234803 | Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut |
Q37176966 | Peroxo and oxo intermediates in mononuclear nonheme iron enzymes and related active sites |
Q64388711 | Phage Mu Gam protein promotes NHEJ in concert with ligase |
Q46262834 | Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action |
Q40604186 | Phenazines and other redox-active antibiotics promote microbial mineral reduction. |
Q33780274 | Phenotypic landscape of a bacterial cell |
Q59055796 | Physicochemical, Spectral, and Biological Studies of Mn(II), Cu(II), Cd(II), Zr(OH)2(IV), and UO2(VI) Compounds with Ligand Containing Thiazolidin-4-one Moiety |
Q38759996 | Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway. |
Q34070201 | Possible structural role of the disaccharide unit in Fe-bleomycin before and after oxygen activation |
Q39656167 | Potentiation of the mutagenicity and recombinagenicity of bleomycin in yeast by unconventional intercalating agents |
Q36553266 | Predicting enhanced cell killing through PARP inhibition |
Q24802920 | Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma |
Q35773665 | Pro-Oxidant Activity of Amine-Pyridine-Based Iron Complexes Efficiently Kills Cancer and Cancer Stem-Like Cells |
Q89611723 | Progress toward the development of the small molecule equivalent of small interfering RNA |
Q38780402 | Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics |
Q37224681 | Protective effect of spin-labeled 1-ethyl-1-nitrosourea against oxidative stress in liver induced by antitumor drugs and radiation |
Q41193471 | QSAR-assisted virtual screening of lead-like molecules from marine and microbial natural sources for antitumor and antibiotic drug discovery. |
Q21559579 | Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens |
Q40447301 | Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. |
Q28383918 | Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model |
Q26765518 | Role of endoplasmic reticulum stress in drug-induced toxicity |
Q42442718 | Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis |
Q28289478 | SNEV overexpression extends the life span of human endothelial cells |
Q36709313 | Selective tumor cell targeting by the disaccharide moiety of bleomycin |
Q34223506 | Solution structure of Fe(II)-azide-bleomycin derived from NMR data: transition from Fe(II)-bleomycin to Fe(II)-azide-bleomycin as derived from NMR data and structural calculations |
Q38360967 | Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation |
Q37205681 | Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity |
Q39471213 | Structure-activity relationship study of copper(II) complexes with 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (4'-methylbenzoyl) hydrazone: synthesis, structures, DNA and protein interaction studies, antioxidative and cytotoxic activity |
Q42322588 | Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands |
Q38832977 | Synthesis, Molecular Structure, DNA/Protein Binding, Cytotoxicity, Apoptosis, Reactive Oxygen Species, and Mitochondrial Membrane Potential of Dibenzoxanthenes Derivatives |
Q36360955 | Synthesis, Spectroscopic Characterization, and In Vitro Antimicrobial Studies of Pyridine-2-Carboxylic Acid N'-(4-Chloro-Benzoyl)-Hydrazide and Its Co(II), Ni(II), and Cu(II) Complexes |
Q44508070 | Synthesis, biological evaluation and DNA binding properties of novel bleomycin analogues |
Q27640195 | Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion |
Q52904189 | Synthesis, characterization, DNA interactions, DNA cleavage, radical scavenging activity, antibacterial, anti-proliferative and docking studies of new transition metal complexes. |
Q74180556 | Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline |
Q42870974 | Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments |
Q40537821 | Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress |
Q38783137 | The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence |
Q33392888 | The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. |
Q35844576 | The colibactin warhead crosslinks DNA. |
Q38290539 | The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis |
Q40643664 | The regulatory factor X protein MoRfx1 is required for development and pathogenicity in the rice blast fungus Magnaporthe oryzae. |
Q42608593 | The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics |
Q42186795 | Tocopherol supplementation reduces NO production and pulmonary inflammatory response to bleomycin |
Q37613626 | Total syntheses of (-)-pyrimidoblamic acid and P-3A. |
Q46795515 | Use of short duplexes for the analysis of the sequence-dependent cleavage of DNA by a chemical nuclease, a manganese porphyrin. |
Q64268237 | Vitamin C as a Modulator of the Response to Cancer Therapy |
Q64387425 | Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin |
Q38719028 | XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF. |
Q91964079 | Zinc(II) Terpyridine Complexes: Substituent Effect on Photoluminescence, Antiproliferative Activity, and DNA Interaction |
Q39184979 | Zinc(II) complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers that trigger DNA damage-mediated p53 phosphorylation in cancer cells. |
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