Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA1/LPA3 Receptor Antagonist

scientific article published on December 1, 2001

Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA1/LPA3 Receptor Antagonist is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/MOL.60.6.1173
P953full work available at URLhttp://molpharm.aspetjournals.org/cgi/content/abstract/60/6/1173
https://api.elsevier.com/content/article/PII:S0026895X24089909?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0026895X24089909?httpAccept=text/xml
https://syndication.highwire.org/content/doi/10.1124/mol.60.6.1173
P698PubMed publication ID11723223

P2093author name stringK. R. Lynch
T. L. Macdonald
A. M. Schreihofer
Y. V. Mukhin
B. H. Heasley
C. E. Heise
W. L. Santos
P2860cites workMolecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acidQ22010389
Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathwayQ22253210
Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acidQ24309021
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1Q24314828
Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids1Q24316056
Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic AcidQ24321223
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortexQ24321349
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8Q28143704
A rat G protein-coupled receptor selectively expressed in myelin-forming cellsQ28569876
The molecular pharmacology of lysophosphatidate signalingQ30305675
Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.Q30306254
Characterization of a Receptor Subtype-Selective Lysophosphatidic Acid MimeticQ30471683
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cellsQ34017706
LPA: a novel lipid mediator with diverse biological actionsQ35632934
Lysophosphatidic acid signallingQ40444988
Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acidQ42866943
Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal speciesQ44500797
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors.Q50760286
Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators?Q71965824
Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factorQ72519053
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1173-1180
P577publication date2001-12-01
P1433published inMolecular PharmacologyQ1943386
P1476titleActivity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist
Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA1/LPA3 Receptor Antagonist
P478volume60

Reverse relations

cites work (P2860)
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Q41954435Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA
Q37685105Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells
Q38035634Current progress in non-Edg family LPA receptor research
Q30439954Engineering vascularized tissues using natural and synthetic small molecules
Q84746759First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor
Q33610285Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers
Q30429523International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
Q40633092Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors
Q46228136LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction
Q37503698Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase
Q42021207Lysophosphatidic acid receptor agonists and antagonists (WO2010051053)
Q30573574Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.
Q42716792Lysophosphatidic acid stimulates epidermal growth factor‐family ectodomain shedding and paracrine signaling from human lung fibroblasts
Q28294232Lysophosphatidylethanolamine utilizes LPA1 and CD97 in MDA-MB-231 breast cancer cells
Q36930850Lysophospholipid interactions with protein targets
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Q30410634Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors
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Q35551835Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors
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