The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice☆

scientific article published on April 1, 2003

The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice☆ is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1521-6616(02)00054-2
P8608Fatcat IDrelease_2iz4lbyuwvh6npxmicrlegdsxq
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S1521661602000542?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S1521661602000542?httpAccept=text/xml
P698PubMed publication ID12738247

P2093author name stringMeng Chen
Jerry L. Nadler
Volker Brinkmann
Runpei Wu
Zandong Yang
Kevin R. Lynch
Justin D. Ellett
Lawrence B. Fialkow
P2860cites workAlteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsQ29618071
Suppression of autoimmune diabetes by viral IL-10 gene transferQ30309447
The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic miceQ30309929
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metaboliteQ34339041
Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanolsQ34510369
Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720.Q34756546
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunityQ34786932
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null miceQ36367653
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
Effect of a new immunosuppressive agent, FTY720, on survival of islet allograftsQ40845989
The identification of myriocin-binding proteinsQ40963836
FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppressionQ43552626
Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.Q44002416
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.Q52026935
Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouseQ68313988
Insulin-dependent diabetes mellitusQ71046915
FTY720, a new immunosuppressant, promotes long-term graft survival and inhibits the progression of graft coronary artery disease in a murine model of cardiac transplantationQ73004340
Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in ratsQ73376348
FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activationQ73423109
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytesQ73531760
Prevention of graft vessel disease by combined FTY720/cyclosporine. A treatment in a rat carotid artery transplantation modelQ74052937
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
immunologyQ101929
P304page(s)30-35
P577publication date2003-04-01
P1433published inClinical ImmunologyQ15752921
P1476titleThe immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice☆
P478volume107

Reverse relations

cites work (P2860)
Q52578826Abnormal islet sphingolipid metabolism in type 1 diabetes.
Q30427148Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes
Q60938765Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson's Disease and Diabetes as Well as Potential Therapies?
Q23923263Disruption of sphingolipid homeostasis by myriocin, a mycotoxin, reduces thymic and splenic T-lymphocyte populations
Q36057311Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice
Q28066824Experimental Diabetes Mellitus in Different Animal Models
Q38458872FTY720 preserved islet β-cell mass by inhibiting apoptosis and increasing survival of β-cells in db/db mice
Q37088194From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.
Q48169015Local delivery of fingolimod from three-dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model
Q30428016Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells
Q28542948Prolonging survival of corneal transplantation by selective sphingosine-1-phosphate receptor 1 agonist
Q48529387Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod
Q30434189Regulation of learning and memory by meningeal immunity: a key role for IL-4
Q36861002Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism
Q44813941The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
Q34274256The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
Q24681206The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
Q37128721The role of sphingosine-1-phosphate and its receptors in asthma
Q39021621The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases
Q57012316Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure
Q80716400[FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis]

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