Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells

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Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/08916934.2010.499885
P932PMC publication ID2994995
P698PubMed publication ID20695767
P5875ResearchGate publication ID45582226

P50authorKlaus F. LeyQ89016809
P2093author name stringJerry L Nadler
Marcia McDuffie
Margaret A Morris
P2860cites workEdg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturationQ24629370
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid miceQ28242854
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrowQ28260601
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigrationQ28592508
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsQ29618071
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice☆Q30310830
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.Q30435822
Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.Q30438675
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organsQ33869799
Sphingosine 1-phosphate signalling in mammalian cellsQ33958247
T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD miceQ36356330
Autoimmunity during lymphopenia: a two-hit modelQ36502790
Tipping the gatekeeper: S1P regulation of endothelial barrier functionQ36727643
Fingolimod: a novel immunosuppressant for multiple sclerosisQ36929186
Can we learn from viruses how to prevent type 1 diabetes?: the role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapiesQ37023049
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte hominQ41042455
Prevention of autoimmune diabetes by FTY720 in nonobese diabetic miceQ44260906
FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors.Q44758554
The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.Q44813941
NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cellsQ46113851
Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometryQ46377682
Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720.Q46478164
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine produQ48032286
New immunosuppresor strategies in the treatment of murine lupus nephritis.Q51767729
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) miceQ68889645
Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cellsQ70983849
P433issue2
P304page(s)115-128
P577publication date2010-08-09
P1433published inAutoimmunityQ4826348
P1476titlePrevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells
P478volume44

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cites work (P2860)
Q38021696Autoimmunity in 2011.
Q30422344Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development
Q38458872FTY720 preserved islet β-cell mass by inhibiting apoptosis and increasing survival of β-cells in db/db mice
Q91565357Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome
Q37610134Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome.
Q35551835Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors
Q40117186The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis.
Q44146198Treatment of autoimmune diabetes in NOD mice by Toll-like receptor 2 tolerance in conjunction with dipeptidyl peptidase 4 inhibition

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