Klaus F. Ley

biomedical engineering researcher

Born 1957-01-01

Klaus F. Ley is …
instance of (P31):
humanQ5

External links are
P268Bibliothèque nationale de France ID13612836h
P227GND ID10834326X
P269IdRef ID120129434
P213ISNI0000000028445774
P244Library of Congress authority IDn00120582
P8189National Library of Israel J9U ID987007374302505171
P691NL CR AUT IDmzk20191053550
P1207NUKAT IDn2012275832
P496ORCID iD0000-0001-9339-3672
P214VIAF ID22316887

P166award receivedFellow of the Biomedical Engineering SocietyQ59767038
Fellow of the American Institute for Medical and Biological EngineeringQ59767813
Special Recognition Award in Vascular BiologyQ124980531
P108employerMedical College of GeorgiaQ16973985
P734family nameLeyQ37476695
LeyQ37476695
LeyQ37476695
P101field of workimmunologyQ101929
allergologyQ1046686
medicineQ11190
atherosclerosisQ12252367
P735given nameKlausQ15635230
KlausQ15635230
P1412languages spoken, written or signedEnglishQ1860
P106occupationphysicianQ39631
university teacherQ1622272
immunologistQ12119633
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q30422398'Slings' enable neutrophil rolling at high shear
Q89186695A clinically applicable adjuvant for an atherosclerosis vaccine in mice
Q48095930A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
Q38737500ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis
Q30439838Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
Q30425907Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites
Q53587674Analysis of leukocyte rolling in vivo and in vitro.
Q30442113Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis
Q30438807Arterial macrophages and regenerating endothelial cells express P-selectin in atherosclerosis-prone apolipoprotein E-deficient mice
Q37415733Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100.
Q46473311Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells
Q57784166Atherosclerosis
Q90311018Atherosclerosis in the single-cell era
Q52653300Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.
Q30312141Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin
Q30422974B-cell aortic homing and atheroprotection depend on Id3.
Q24800620Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung
Q36079808Beyond vascular inflammation--recent advances in understanding atherosclerosis
Q30441773Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration
Q41576199CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis
Q30441065CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury
Q90556187CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice
Q30433527CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages
Q30434720CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo
Q30444644CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall
Q30427448Cell protrusions and tethers: a unified approach
Q33385873Chapter 11. Intravital microscopic investigation of leukocyte interactions with the blood vessel wall
Q112709117Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease
Q30309533Chemokines and chemokine receptors in leukocyte trafficking
Q64899223Circulating T cell-monocyte complexes are markers of immune perturbations.
Q30310323Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.
Q30442280Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation
Q90248384Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages
Q30439575Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung
Q30439952Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis
Q30434635Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice
Q30312227Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice
Q41777689Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms
Q40703820Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
Q46306927Developing Neutrophils Must Eat…Themselves!
Q29616446Development of monocytes, macrophages, and dendritic cells
Q30852175Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues
Q82192703Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease
Q49316497Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation
Q30443792Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis
Q104068287Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
Q112748056Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis
Q30853668Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis
Q98280885Epsin-mediated degradation of IP3R1 fuels atherosclerosis
Q30434096Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
Q35379428Flow cytometry analysis of immune cells within murine aortas
Q93049938Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling
Q30440796Galphai2 is required for chemokine-induced neutrophil arrest
Q29547271Getting to the site of inflammation: the leukocyte adhesion cascade updated
Q37349468Glycosylation in immune cell trafficking
Q36488981Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo
Q110176737Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Q36905546Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils
Q52936356HGF Guides T Cells into the Heart.
Q90865187High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis
Q30441343Hold on to your endothelium: postarrest steps of the leukocyte adhesion cascade
Q26745544How Mouse Macrophages Sense What Is Going On.
Q36235238How dendritic cells shape atherosclerosis
Q30435495IL-17A controls IL-17F production and maintains blood neutrophil counts in mice
Q30439191IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor
Q28256188IL-17A-producing neutrophil-regulatory Tn lymphocytes
Q30445137IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice
Q30852948IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Q90090302Imaging of the immune system - towards a subcellular and molecular understanding
Q37325024Immune and inflammatory mechanisms of atherosclerosis (*)
Q91088774Immunity and Inflammation in Atherosclerosis
Q34737657Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation
Q24294246Induction of dendritic cell-like phenotype in macrophages during foam cell formation
Q30443409Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.
Q49875322Inflammatory Pathways Regulated By Tumor-Necrosis Receptor Associated Factor 1 Protect From Metabolic Consequences In Diet-Induced Obesity
Q30443305Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity
Q30429445Interleukin 17 in vascular inflammation
Q30360686Intravital live cell triggered imaging system reveals monocyte patrolling and macrophage migration in atherosclerotic arteries.
Q94585147Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance
Q98300034Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling
Q30308891L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation
Q90585134Leaking chemokines confuse neutrophils
Q36916079Leukocyte Adhesion Deficiency IV. Monocyte Integrin Activation Deficiency in Cystic Fibrosis
Q36908674Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation
Q27027232Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
Q30441672Leukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo
Q28071784Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis
Q30311902Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays
Q30440410Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
Q48327546M1 Means Kill; M2 Means Heal.
Q30352961MISTICA: Minimum Spanning Tree-Based Coarse Image Alignment for Microscopy Image Sequences.
Q92617815Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages
Q30438116Macrophage differentiation to foam cells
Q35087352Macrophages at the fork in the road to health or disease
Q30441417Mechanisms and consequences of neutrophil interaction with the endothelium
Q30441275Mechanisms by which diabetes increases cardiovascular disease
Q97555853Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
Q27334387Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils
Q30448705Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution
Q90595072Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions
Q37116502Monocyte-endothelial cell interactions in the development of atherosclerosis
Q57446339Multi-cell 3D tracking with adaptive acceptance gates
Q42573987NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis
Q50187407Natural Killer Cells at Ease: Atherosclerosis Is Not Affected by Genetic Depletion or Hyperactivation of Natural Killer Cells.
Q38665299Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival
Q30310983Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo
Q92594328Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns
Q38018949Neutrophil arrest by LFA-1 activation
Q27329905Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.
Q90365322Neutrophils: New insights and open questions
Q37517321New insights into leukocyte recruitment by intravital microscopy
Q116851231Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
Q92820698Opportunities for an atherosclerosis vaccine: From mice to humans
Q30435711Oxidative modification of leukocyte adhesion
Q59066080Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
Q30310860P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules
Q30453100P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow
Q97679530Pathogenic Autoimmunity in Atherosclerosis Evolves from Initially Protective ApoB-Reactive CD4+ T-Regulatory Cells
Q47193091Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation
Q30436326Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.
Q90759569Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Q37131719Platelet chemokines in vascular disease
Q30441637Platelet-neutrophil-interactions: linking hemostasis and inflammation
Q30428016Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells
Q27329528Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.
Q30439674Protective effects of isoflurane pretreatment in endotoxin-induced lung injury
Q93109420Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem
Q52626860Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.
Q104477761Regulatory T Cell Stability and Plasticity in Atherosclerosis
Q36057934Role of the endothelial surface layer in neutrophil recruitment
Q45970808Rolling neutrophils form tethers and slings under physiologic conditions in vivo.
Q30311866Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes
Q41899805SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration
Q41932483Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis
Q30433441Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation
Q30437105Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury
Q30310115Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice
Q30440648Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
Q44189769Sialyltransferase specificity in selectin ligand formation
Q93177811Single Cell RNA Sequencing in Atherosclerosis Research
Q30310789Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice
Q52653301Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis.
Q28512961Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720
Q28262554Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor
Q30440643Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.
Q45325021Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
Q101040788Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy
Q30310151T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice
Q90590521T cell subsets and functions in atherosclerosis
Q42467351Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response
Q63915270The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium
Q30439653The primary defect in experimental ileitis originates from a nonhematopoietic source
Q30437474The role of platelets in acute lung injury (ALI)
Q91480328The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration
Q30444009Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury
Q30438675Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.
Q52726804Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
Q92719665Vaccination against atherosclerosis
Q35600876Vaccination to modulate atherosclerosis
Q30444182Vascular adhesion molecules in atherosclerosis
Q30310142Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase
Q30310325Viscosity-independent velocity of neutrophils rolling on p-selectin in vitro or in vivo
Q42557605Waking up the stem cell niche: how hematopoietic stem cells generate inflammatory monocytes after stroke.
Q57445739α2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammation

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