Opportunities for an atherosclerosis vaccine: From mice to humans

scientific article published on 18 January 2020

Opportunities for an atherosclerosis vaccine: From mice to humans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2019.12.039
P932PMC publication ID7939143
P698PubMed publication ID31964554

P50authorKlaus F. LeyQ89016809
P2093author name stringKouji Kobiyama
Yanal Ghosheh
Payel Roy
Amal J Ali
P2860cites workBinding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradationQ24303660
Effect of the adult pneumococcal polysaccharide vaccine on cardiovascular disease: a systematic review and meta-analysisQ26801433
Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis ImmunityQ28072367
Autoreactive HSP60 epitope-specific T-cells in early human atherosclerotic lesionsQ28710388
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- MiceQ30276940
B-1b Cells Secrete Atheroprotective IgM and Attenuate AtherosclerosisQ30279171
Ii-Key/MHC class II epitope hybrids: a strategy that enhances MHC class II epitope loading to create more potent peptide vaccines.Q30359230
Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular diseaseQ31135767
Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient miceQ31807203
Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosisQ33207408
Safety and efficacy trial of adipose-tissue derived oral preparation V-6 Immunitor (V-6): results of open-label, two-month, follow-up studyQ33663533
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responsesQ33819043
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.Q34047773
Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccineQ34238712
IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis.Q34364890
Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?Q34446467
A cholesterol-lowering VLP vaccine that targets PCSK9Q34496015
Genetics of coronary artery disease: discovery, biology and clinical translationQ34553141
Characterization of resident B cells of vascular walls in human atherosclerotic patients.Q34955086
Decreased regulatory T cells in vulnerable atherosclerotic lesions: imbalance between pro- and anti-inflammatory cells in atherosclerosisQ35034094
Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemiaQ35133174
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouseQ35213550
Heat shock protein 60 and immune inflammatory responses in atherosclerosisQ35540113
Type 1 diabetes immunotherapy using polyclonal regulatory T cellsQ36509805
Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challengesQ36968971
A systems biology framework identifies molecular underpinnings of coronary heart diseaseQ37119481
High Serum Immunoglobulin G and M Levels Predict Freedom From Adverse Cardiovascular Events in Hypertension: A Nested Case-Control Substudy of the Anglo-Scandinavian Cardiac Outcomes TrialQ37149945
Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokinesQ60746676
Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe−/− miceQ60948409
Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable PlaqueQ61848544
Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.Q64915291
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosisQ72209255
Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular eventsQ79533802
Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosisQ79711302
Atheroprotective immunization with MDA-modified apo B-100 peptide sequences is associated with activation of Th2 specific antibody expressionQ80417831
Humoral immune response against defined oxidized low-density lipoprotein antigens reflects structure and disease activity of carotid plaquesQ81652647
Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosisQ82956532
Toll-like receptor blocker slows beta cell death in type 1 diabetesQ83408117
Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient miceQ83880274
Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studiesQ86095801
Adventitial macrophage and lymphocyte accumulation accompanying early stages of human coronary atherogenesisQ87566839
Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-upQ87620046
Production of a plant-derived immunogenic protein targeting ApoB100 and CETP: toward a plant-based atherosclerosis vaccineQ87629622
Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery systemQ91857565
B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell ResponsesQ92045287
Mass spectrometry-based identification of MHC-bound peptides for immunopeptidomicsQ92052807
Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and StabilityQ92508225
Immune and inflammatory mechanisms of atherosclerosis (*)Q37325024
Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100.Q37415733
The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants.Q37625241
CD4+ T-cell activation for immunotherapy of malignancies using Ii-Key/MHC class II epitope hybrid vaccinesQ37990213
Engineering lactococci and lactobacilli for human healthQ38121295
Transgenic plants: a 5-year update on oral antipathogen vaccine developmentQ38243438
Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE).Q38413454
Antiinflammatory Therapy with Canakinumab for Atherosclerotic DiseaseQ38606033
Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic ArthritisQ38958215
The Two Faces of Interleukin-17A in AtherosclerosisQ39052489
The safety and immunogenicity of a CETP vaccine in healthy adultsQ40574796
Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary EventsQ40886797
Mycobacterial heat shock protein 65 (mbHSP65)-induced atherosclerosis: Preventive oral tolerization and definition of atheroprotective and atherogenic mbHSP65 peptides.Q41076906
CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive AtherosclerosisQ41576199
Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trialQ42504585
Effect of immunization against ox-LDL with two different antigens on formation and development of atherosclerosisQ42970733
Effect of oral immunization with pooled antigens derived from adipose tissue on atherosclerosis and obesity indicesQ43179678
Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ+ Th1/Tregs.Q43273026
Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosisQ43550562
Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient miceQ43633700
Immunoglobulin M Type of Autoantibodies to Oxidized Low-Density Lipoprotein Has an Inverse Relation to Carotid Artery AtherosclerosisQ44608860
Circulating CD40+ and CD86+ B cell subsets demonstrate opposing associations with risk of stroke.Q45996735
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.Q46095021
PCSK9 Inhibitors: Economics and Policy.Q46248321
B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesionsQ46365271
Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodiesQ46376396
Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cellsQ46473311
The Th17/Treg imbalance in patients with acute coronary syndromeQ46737661
Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) miceQ46804215
Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesisQ47788311
Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus.Q49072554
Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart AssociationQ49546493
Atherosclerosis Is an Inflammatory Disease which Lacks a Common Anti-inflammatory Therapy: How Human Genetics Can Help to This Issue. A Narrative Review.Q50318400
The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.Q50931633
Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice.Q51760069
Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.Q52626860
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.Q52726244
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.Q53153760
Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis.Q53524929
The opposite-direction modulation of CD4+CD25+ Tregs and T helper 1 cells in acute coronary syndromes.Q53551964
Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.Q53591929
Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome.Q54375886
The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.Q55318081
Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromesQ56901831
Natural regulatory T cells control the development of atherosclerosis in miceQ58149268
Antigen-Driven Evolution of B Lymphocytes in Coronary Atherosclerotic PlaquesQ58228906
Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trialQ58732372
P577publication date2020-01-18
P1433published inVaccineQ7907941
P1476titleOpportunities for an atherosclerosis vaccine: From mice to humans

Reverse relations

cites work (P2860)
Q97886132Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish
Q90590521T cell subsets and functions in atherosclerosis