T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

scientific article

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20110308
P932PMC publication ID3173240
P698PubMed publication ID21606508
P5875ResearchGate publication ID51159968

P50authorKristin A. HogquistQ40289842
P2093author name stringYan Xing
Jonathan S Maltzman
Amy E Moran
Nicole R Cunningham
Jennifer Punt
Keli L Holzapfel
P2860cites workClass I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cellsQ24653129
Autoreactivity by design: innate B and T lymphocytesQ28208367
The fourth way? Harnessing aggressive tendencies in the thymusQ28294493
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckQ28506433
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoiresQ28590409
CD1 recognition by mouse NK1+ T lymphocytesQ28591238
T cell receptor antagonist peptides induce positive selectionQ29618820
Rare, structurally homologous self-peptides promote thymocyte positive selectionQ30844919
Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cellsQ33599438
Sea-level fingerprinting as a direct test for the source of global meltwater pulse IA.Q34118671
Positive and negative selection of T cellsQ34157557
Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytesQ34162002
Transcriptional analysis of clonal deletion in vivoQ80582163
A thymic precursor to the NK T cell lineageQ95783850
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuliQ34427465
Intraclonal competition limits the fate determination of regulatory T cells in the thymusQ34607464
iNKT cell autoreactivity: what is 'self' and how is it recognized?Q34760309
Natural killer T cells: know thyselfQ35749476
Regulation of immunity by self-reactive T cellsQ36148406
The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biologyQ36176101
LAT-mediated signaling in CD4+CD25+ regulatory T cell developmentQ36227859
Thymic emigration revisitedQ36229138
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramersQ36368804
Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cellsQ36401236
Characterization of the early stages of thymic NKT cell developmentQ36402797
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.Q36725004
NR4A nuclear orphan receptors: protective in vascular disease?Q36947980
TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizesQ37377465
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cellsQ37394279
Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis.Q38288944
Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingQ39773899
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organsQ40307375
Lysosomal glycosphingolipid recognition by NKT cellsQ40493118
Identification of Genes Induced during Apoptosis in T LymphocytesQ40495471
Mouse CD1-specific NK1 T cells: development, specificity, and functionQ41464349
Type I interferon-mediated stimulation of T cells by CpG DNAQ41824775
Complete but curtailed T-cell response to very low-affinity antigenQ41902378
Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded moleculesQ41922560
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cellsQ42114183
The influence of CD1d in postselection NKT cell maturation and homeostasisQ42483693
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell developmentQ42932412
Regulatory T cell development in the absence of functional Foxp3.Q44440268
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selectionQ44593628
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.Q52004102
Long-term retention of mature NK1.1+ NKT cells in the thymus.Q52022963
Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.Q52110901
Foxp3-dependent programme of regulatory T-cell differentiationQ59084714
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
The Elusive NKT Cell Antigen--Is the Search Over?Q60489521
A low affinity TCR ligand restores positive selection of CD8+ T cells in vivoQ64379827
Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP ThymocytesQ64448638
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoireQ77328529
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptidesQ77815121
Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expressionQ77995835
Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cellsQ80034250
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1279-1289
P577publication date2011-05-23
P1433published inJournal of Experimental MedicineQ3186912
P1476titleT cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
P478volume208

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Q38368925Orchestration of invariant natural killer T cell development by E and Id proteins
Q45159606Origin of monocytes and macrophages in a committed progenitor
Q33638200Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages
Q34195209PD-1 regulates extrathymic regulatory T-cell differentiation
Q90681799PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia
Q36482182PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function
Q35981147PTPN22 alters the development of regulatory T cells in the thymus
Q37600124PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells
Q36302397Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.
Q35931571Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Q33597132Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation
Q40420550Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureus
Q47193091Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation
Q27330247Patrolling monocytes control tumor metastasis to the lung.
Q58804351Peptide Antigen Concentration Modulates Digital NFAT1 Activation in Primary Mouse Naive CD8 T Cells as Measured by Flow Cytometry of Isolated Cell Nuclei
Q40455041Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.
Q37464168Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
Q52332759Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells.
Q36054460Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Q29391777Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
Q97067640Prediabetes Induced by a Single Autoimmune B Cell Clone
Q37019903Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.
Q35735244Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens
Q48306782Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota.
Q36922577Profound impairment of adaptive immune responses by alkylating chemotherapy
Q100305090Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants
Q33894832Progressive Changes in CXCR4 Expression That Define Thymocyte Positive Selection Are Dispensable For Both Innate and Conventional αβT-cell Development
Q36377731Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.
Q41613842Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway
Q38918816Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.
Q37315012Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1.
Q92034221RRAS2 shapes the TCR repertoire by setting the threshold for negative selection
Q39343055Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery
Q35917978Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis.
Q91594871Rapid expansion of Treg cells protects from collateral colitis following a viral trigger
Q46288731Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.
Q95323063Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Q33720359Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential
Q62671646Recording the wild lives of immune cells
Q36278062Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
Q38527820Regulation of NKT Cell Localization in Homeostasis and Infection
Q47407214Regulation of SATB1 during thymocyte development by TCR signaling
Q41030514Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Q38197973Regulation of the tolerogenic function of steady-state DCs.
Q52626860Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.
Q90573900Regulatory T Cell Development in the Thymus
Q40901418Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection
Q38927531Regulatory T Cells: Central Concepts from Ontogeny to Therapy
Q35690416Regulatory T cell identity: formation and maintenance
Q34166571Regulatory T cells and their roles in immune dysregulation and allergy.
Q35472407Regulatory T cells require TCR signaling for their suppressive function
Q29620731Regulatory T cells: mechanisms of differentiation and function
Q38202988Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation
Q36176983Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease
Q35129219Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue
Q30574747Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells
Q39188794Relationship between CD4 Regulatory T Cells and Anergy In Vivo
Q92913113Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Q93037335Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo
Q93347701Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells
Q52715431Revealing the specificity of regulatory T cells in murine autoimmune diabetes.
Q34125011Revisiting thymic positive selection and the mature T cell repertoire for antigen
Q90288573Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation
Q40771683SHARPIN controls the development of regulatory T cells
Q92129398SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection
Q39659304SLAM-associated protein favors the development of iNKT2 over iNKT17 cells
Q64096305SLAM-ing the brakes on iNKT cell selection
Q33799269Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development
Q37982939Selection of regulatory T cells in the thymus
Q36456282Selection of self-reactive T cells in the thymus
Q37552169Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
Q34003592Shaping the repertoire of tumor-infiltrating effector and regulatory T cells
Q40474396Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.
Q38187171Signals and pathways controlling regulatory T cells
Q91235211Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1- T-bet+ intraepithelial lymphocyte precursors
Q50055143Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Q92376163Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression
Q37298525Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
Q36506961Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.
Q94932167Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling
Q38016483Strategy of lipid recognition by invariant natural killer T cells: 'one for all and all for one'.
Q38353298Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation
Q100316573Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions
Q50282444Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.
Q30388030Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells
Q40355426Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity
Q35903358Surfactant protein A modulates induction of regulatory T cells via TGF-β.
Q41847407Sustained interactions between T cell receptors and antigens promote the differentiation of CD4⁺ memory T cells.
Q64084952T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells
Q26765917T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells
Q93109740T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33
Q57235281T cell cytolytic capacity is independent of initial stimulation strength
Q26749508T cell receptor signalling in the control of regulatory T cell differentiation and function
Q34228163T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity
Q28276597T cells and their eons-old obsession with MHC
Q33559914T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.
Q37969840T-cell receptor affinity in thymic development.
Q90317657T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate
Q41942006T-cell tolerance: central and peripheral
Q89055232TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype
Q33849292TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
Q35972640TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).
Q92623707TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice
Q41333491TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice
Q61137128TCR signal strength controls thymic differentiation of iNKT cell subsets
Q33605976TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection
Q51095824TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells.
Q27012877TGF-β: guardian of T cell function
Q38683647THEMIS: Two Models, Different Thresholds
Q92734206Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia
Q48583884Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
Q41502539Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.
Q50278432The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells
Q36406557The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens
Q96136920The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis
Q91843682The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling
Q91782684The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells
Q92715421The Role of the Thymus in the Immune Response
Q34734561The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens
Q34071164The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Q51764735The full spectrum of human naive T cells.
Q90017815The ins and outs of type I iNKT cell development
Q28511366The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function
Q48358940The mechanisms shaping the repertoire of CD4+  Foxp3+ regulatory T cells.
Q35169551The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3
Q34734626The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs
Q92453276The orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor
Q36074906The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development
Q33666979The role of T-cell receptor recognition of peptide:MHC complexes in the formation and activity of Foxp3⁺ regulatory T cells
Q35143413The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function
Q35115481The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation
Q46259603The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor
Q35590727The split personality of NKT cells in malignancy, autoimmune and allergic disorders
Q47105632The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery.
Q91594487The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection
Q35537706The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.
Q35883418The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes
Q35568453The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
Q36737300The transcriptional repressor NKAP is required for the development of iNKT cells
Q60241510The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
Q37687058Themis sets the signal threshold for positive and negative selection in T-cell development
Q39759566Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Q35686111Thymic low affinity/avidity interaction selects natural Th1 cells
Q48220577Thymic progenitors of TCRαβ+ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development
Q91045855Thymic regulatory T cells arise via two distinct developmental programs
Q37544084Thymocyte apoptosis drives the intrathymic generation of regulatory T cells
Q36068343Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness
Q36799097Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection
Q36398769Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation
Q34493722Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response
Q41868847Tissue-resident T cells lose their S1P1 exit visas
Q83225286Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
Q27008423To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy
Q46680134Tonic Signals: Why Do Lymphocytes Bother?
Q36801851Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.
Q94474166Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity
Q38135555Transcriptional control of regulatory T cell development and function
Q37352068Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
Q50420265Transcriptional regulation and development of regulatory T cells.
Q27012749Transcriptional regulation of the NKT cell lineage
Q93014226Treg Heterogeneity, Function, and Homeostasis
Q36192911Treg cells, life history, and diversity
Q49796168Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs.
Q55221876Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.
Q49574395Unraveling Natural Killer T-Cells Development
Q36514324Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model
Q89629224Very rapid cloning, expression and identifying specificity of T-cell receptors for T-cell engineering
Q94219957Viral MHCI inhibition evades tissue-resident memory T cell formation and responses
Q41086977Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy.
Q27314749Visualization of immediate immune responses to pioneer metastatic cells in the lung.
Q35856488Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling
Q94600452Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1+ T cell development
Q88997923iNKT cells do a fat lot of good
Q64109122miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity
Q34082153αβT cell receptors expressed by CD4(-)CD8αβ(-) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities

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