Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells

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Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1701085
P698PubMed publication ID28947542

P50authorTroy A BaldwinQ64515004
Alexander Y W SuenQ95951821
P2093author name stringLaura M Henao Caviedes
Qian Nancy Hu
P2860cites workBH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytesQ28203083
Aire regulates negative selection of organ-specific T cellsQ28213185
Central tolerance: learning self-control in the thymusQ28275215
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptorQ28512848
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosisQ28591401
T cell receptor antagonist peptides induce positive selectionQ29618820
A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathwayQ33523813
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunityQ34228163
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.Q34474472
The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector functionQ35143413
Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cellsQ35147708
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouseQ35213550
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cellsQ35629308
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profilingQ35724760
Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigensQ35735244
Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in MacrophagesQ35737476
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletionQ35845038
Clonal deletion and the fate of autoreactive thymocytes that survive negative selectionQ35996079
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Q36275699
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune diseaseQ36278062
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsQ36366355
Constitutive class I-restricted exogenous presentation of self antigens in vivoQ36367249
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentationQ36399298
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigensQ36406557
CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursorsQ36586349
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Q36603522
The genetic landscape of type 2 diabetes in miceQ36612875
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domainQ36639961
Murine thymic selection quantified using a unique method to capture deleted T cellsQ36712531
Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.Q37415532
Selection of regulatory T cells in the thymusQ37982939
Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.Q38311983
Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigenQ38810900
Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?Q38999162
Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL.Q39716580
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T CellsQ40188158
Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigenQ41424665
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosisQ42573987
Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic isletsQ43030055
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selectionQ44593628
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomasQ46064858
Gene expression analysis of thymocyte selection in vivoQ47620555
Characterization of transcriptional regulation during negative selection in vivoQ47777685
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.Q50764082
Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens.Q54578300
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.Q55059402
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)3147-3157
P577publication date2017-09-25
P1433published inJournal of ImmunologyQ3521441
P1476titleNur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells
P478volume199

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cites work (P2860)
Q100670731'Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity
Q90131913Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77

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