Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

scientific article

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/EMBOJ/16.8.1865
P3181OpenCitations bibliographic resource ID1624689
P932PMC publication ID1169790
P698PubMed publication ID9155013
P5875ResearchGate publication ID14063584

P2093author name stringF K Chan
D Cado
A Winoto
L E Cheng
P2860cites workNOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3Q24316192
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4Q24652482
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1Q28299331
Unique response pathways are established by allosteric interactions among nuclear hormone receptorsQ28301832
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligandQ28513283
Identification of a new brain-specific transcription factor, NURR1Q28578727
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hairQ28586758
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27Q29617346
The Fas death factorQ29620461
Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptorQ30882418
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamilyQ33669766
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.Q34171602
A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamilyQ34290703
Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cellsQ34315179
The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptorQ34377046
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Identification of the DNA binding site for NGFI-B by genetic selection in yeastQ34955524
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsQ36366355
Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient miceQ36553720
Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosisQ36555939
The role of APO-1-mediated apoptosis in the immune systemQ36677969
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interactionQ36701662
Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathwayQ37591407
Steroid receptor family: structure and functionsQ37938849
Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.Q38311983
Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.Q38326654
Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.Q38338088
Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alphaQ40016532
Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivoQ40018450
Selective events in T cell developmentQ40661180
Peptides in positive and negative selection: a delicate balanceQ40723575
Positive selection of lymphocytesQ40807424
Negative selection of lymphocytesQ40807431
Die and let live: eliminating dangerous lymphocytesQ40984215
Autocrine feedback death and the regulation of mature T lymphocyte antigen responses.Q41098072
Induction of apoptosis in mature T cells by tumour necrosis factorQ41293478
Functional domains and phosphorylation of the orphan receptor Nur77.Q42807755
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selectionQ44593628
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomasQ46064858
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)Q71930737
Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody productionQ72273777
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
Nuclear receptor subfamily 4, group A, member 1Q15312091
Nuclear receptor subfamily 4, group A, member 3Q15312406
P304page(s)1865-1875
P577publication date1997-04-01
P1433published inThe EMBO JournalQ1278554
P1476titleFunctional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
P478volume16

Reverse relations

cites work (P2860)
Q43216947'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression
Q4463859417β-Estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor
Q402006146-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation
Q43648989A TFG-TEC nuclear localization mutant forms complexes with the wild-type TFG-TEC oncoprotein and suppresses its activity
Q28283623A microarray model system identifies potential new target genes of the proto-oncogene HOX11
Q40426627Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
Q34284029Activin and TR3 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated mouse models
Q24618410Akt phosphorylates and regulates the orphan nuclear receptor Nur77
Q38344927Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.
Q38968685Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3β-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.
Q36573114Antagonism between Nur77 and glucocorticoid receptor for control of transcription.
Q36922991Apoptotic signal transduction and T cell tolerance
Q50134139B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors.
Q37381555Balancing the decision of cell proliferation and cell fate
Q60924187Biología celular y molecular de las lesiones ateroscleróticas
Q36744144Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice
Q38945956CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection
Q33885290Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.
Q36951329Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs
Q34082790Cell death control in lymphocytes.
Q41514584Cell death in the regulation of immune responses
Q28275215Central tolerance: learning self-control in the thymus
Q34600502Central tolerance: what have we learned from mice?
Q44442942Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.
Q24302510Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3
Q34829321Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes
Q39952461Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Q24644473DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development
Q28590600Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury
Q24323076Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis
Q39579916Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: transactivation of the TR3/nur77 gene by Tax protein
Q36814082Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells.
Q39698781Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment
Q89047693Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia
Q36639961During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
Q37618290ERK and cell death: ERK location and T cell selection
Q33605384ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain
Q43730411ERK5 regulation in naïve T-cell activation and survival.
Q40873685Early induction of the orphan nuclear receptor NOR-1 during cell death of the human breast cancer cell line MCF-7.
Q35123257Elevation of NR4A3 expression and its possible role in modulating insulin expression in the pancreatic beta cell
Q46105618Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
Q33741881Epitope Density Influences CD8+ Memory T Cell Differentiation
Q42709956Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.
Q36184215Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics
Q33966980GREBP, a cGMP-response element-binding protein repressing the transcription of natriuretic peptide receptor 1 (NPR1/GCA).
Q28748816Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach
Q89997379HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory
Q28513661Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
Q36174093Histone Deacetylase 3 Is Required for Efficient T Cell Development
Q35949614Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes
Q33967970ITAM multiplicity and thymocyte selection: how low can you go?
Q39492998Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells
Q39436081Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene
Q40653038Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1
Q28589679Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR
Q40388143Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation
Q34675225Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.
Q64448633Insights into T-Cell Development from Studies Using Transgenic and Knockout Mice
Q24599847Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis
Q35612936Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory.
Q42953889MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.
Q42034713Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent
Q48027266Matters of life and death: programmed cell death at Cold Spring Harbor
Q36246565Mature T-cell leukemias
Q37011469Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha
Q37868448More than just innate immunity: comparative analysis ofChlamydophila pneumoniaeandChlamydia trachomatiseffects on host-cell gene regulation
Q46006248NF-κB Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death.
Q37274168NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress
Q99637293NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting
Q42536118NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors
Q38325176NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro.
Q34007734NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology
Q35289103NR4A1 promotes PDGF-BB-induced cell colony formation in soft agar
Q40157081Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB.
Q35136005Negative selection--clearing out the bad apples from the T-cell repertoire
Q53648181Neuron-derived orphan receptor 1: working towards a common goal.
Q38300473Neuron-derived orphan receptor-1 (NOR-1) is induced by thrombin and mediates vascular endothelial cell growth
Q24644489Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
Q47703460Novel mechanism of action for Nur77 and antagonism by glucocorticoids: a convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription
Q50764082Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
Q58801877Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
Q36440459Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
Q34126046Nuclear hormone receptors in T lymphocytes
Q28508258Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content
Q35845038Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
Q39716580Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL.
Q47744418Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells
Q40362382Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
Q41701543Nur77 transcription activity correlates with its apoptotic function in vivo
Q58591873Nur77: Key Functions and Therapeutic Prospects in Inflammation-Related Lung Diseases
Q38005745Nur77: a potential therapeutic target in cancer
Q74326182Nurr1 affects pRL-TK but not phRG-B internal control plasmid in genetic reporter system
Q35984215Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
Q36775874Nutrigenomics, beta-cell function and type 2 diabetes
Q36716680Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
Q24314492Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2
Q36370777Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death
Q34326672Orphan nuclear receptor Nur77 regulates androgen receptor gene expression in mouse ovary
Q42801051Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts
Q34481343Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas
Q28576610Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3
Q40249197Prostanoid- and interleukin-1-induced primary genes in cementoblastic cells
Q24321434Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor
Q38574697Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory
Q34170819Receptor-mediated apoptosis in T lymphocytes
Q34707445Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice
Q35138066Regulation of NGFI-B expression during the ovulatory process
Q41336694Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation
Q36680080Ribozyme technology for cancer gene target identification and validation
Q34252319Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis
Q42430892Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers
Q51898262Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus
Q24318635Search for cellular partners of human papillomavirus type 16 E2 protein
Q34228163T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity
Q38350984TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells
Q34588195Targeting Nur77 translocation
Q28594740The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine
Q42814342The AF2 domain of the orphan nuclear receptor TEC is essential for the transcriptional activity of the oncogenic fusion protein EWS/TEC.
Q96136920The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis
Q27641442The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway
Q35599140The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
Q42819470The NR4A family of orphan nuclear receptors are not required for adipogenesis
Q36649696The NR4A nuclear receptor family in eosinophils
Q24677863The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation
Q85964704The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia
Q24540372The NR4A subgroup: immediate early response genes with pleiotropic physiological roles
Q28266694The TFG-TEC oncoprotein induces transcriptional activation of the human β-enolase gene via chromatin modification of the promoter region
Q28365451The aetiology of idiopathic Parkinson's disease
Q37410754The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia
Q35015109The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
Q36903019The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation.
Q28589552The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
Q40542365The oncogenic fusion protein EWS/NOR-1 induces transformation of CFK2 chondrogenic cells
Q33642752The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I.
Q34810098The role of NR4A transcription factors in memory formation
Q28199351The role of TCL1 in human T-cell leukemia
Q34207602The role of molecules that mediate apoptosis in T-cell selection
Q39672712The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection
Q44645818The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression.
Q37452166The transcription factor NR4A3 controls CD103+ dendritic cell migration
Q52181530Thymocyte selection: not by TCR alone.
Q28512848Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
Q52546542Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca(2+)/calmodulin-dependent protein kinase cascade.
Q35003517Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production
Q37008257What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain
Q36558001p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction

Search more.