Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function

Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2018.01797
P932PMC publication ID6085422
P698PubMed publication ID30123220

P2093author name stringHiroshi Ichinose
Maaike W Looman
Carlie J de Vries
Marleen Ansems
Esther D Kers-Rebel
Nina Tel-Karthaus
P2860cites workVaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma PatientsQ56637518
Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma PatientsQ58619940
Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50Q60413739
Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory StimuliQ63363442
Thiopurine biology and pharmacologyQ73256604
Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathwaysQ79598776
Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activationQ84790068
Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drugQ87524606
Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAEQ89209641
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signalingQ24299892
The NR4A subgroup: immediate early response genes with pleiotropic physiological rolesQ24540372
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Patrolling monocytes control tumor metastasis to the lung.Q27330247
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPKQ27682265
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammationQ27700060
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
TRAF6 Is a Critical Factor for Dendritic Cell Maturation and DevelopmentQ28505658
Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activationQ28513661
Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINORQ28589679
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosisQ28591401
The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurineQ28594740
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed settingQ29618424
Melanoma immunotherapy using mature DCs expressing the constitutive proteasome.Q30541002
Minireview: Nuclear receptors, hematopoiesis, and stem cellsQ33576478
Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardiumQ33596007
Prolonged survival of human-kidney homografts by immunosuppressive drug therapyQ34253014
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cellsQ34265072
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuliQ34427465
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.Q34474472
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responsesQ34551946
Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrowQ34660094
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancerQ34771536
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cellsQ35015109
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumorsQ35020448
Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cellsQ35032724
The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in miceQ35165174
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouseQ35213550
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.Q50764082
Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.Q52049353
LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis.Q52728752
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life.Q52780418
Trial watch: Dendritic cell-based anticancer immunotherapy.Q53109846
Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.Q53574931
Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation.Q53575755
Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.Q53801260
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.Q54166633
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responsesQ39758426
Cytosporone B is an agonist for nuclear orphan receptor Nur77.Q39952461
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cellsQ40063189
6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formationQ40200614
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathwaysQ40426627
Immunosuppressive drugs in Crohn's diseaseQ40648077
Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1Q40653038
DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.Q40742011
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.Q42135532
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzeneQ42220799
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosisQ42573987
Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccinationQ42969701
A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitroQ43100978
The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cellsQ44190983
Vitamin D controls murine and human plasmacytoid dendritic cell functionQ44287414
6-Mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1.Q44698407
CD14 is required for MyD88-independent LPS signaling.Q45990170
Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cellsQ46555456
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccinationQ46885041
Dendrogenin A drives LXR to trigger lethal autophagy in cancers.Q47107657
The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells.Q47820571
Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients.Q48754596
Ligand-dependent transcriptional induction of lethal autophagy: a new perspective for cancer treatmentQ49714659
The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers.Q50153633
Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell HomeostasisQ35679745
Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in MacrophagesQ35737476
Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletionQ35845038
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.Q35866588
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytesQ35883418
Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and toleranceQ35942458
Dendritic cell biologyQ36287483
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cellsQ36366355
NR4A nuclear receptors in immunity and atherosclerosisQ36451849
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in miceQ36528962
Dendritic cell subsets and type I diabetes: focus upon DC-based therapyQ36557395
Innate immune system regulation of nuclear hormone receptors in metabolic diseasesQ36741784
6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulationQ36796853
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.Q36801851
Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour propertiesQ36906770
Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alphaQ37011469
Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic CellsQ37086985
Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stressQ37294245
Dendritic cells from bench to bedside and backQ37361730
The transcription factor NR4A3 controls CD103+ dendritic cell migrationQ37452166
Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposalQ37503524
Directing dendritic cell immunotherapy towards successful cancer treatmentQ37754014
Targeting NR4A1 (TR3) in cancer cells and tumorsQ37825901
Inflammation: a role for NR4A orphan nuclear receptors?Q37856432
Cellular based cancer vaccines: type 1 polarization of dendritic cells.Q38029745
Therapeutic dendritic cell-based cancer vaccines: the state of the art.Q38165192
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular unitsQ38751291
The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System InflammationQ38836172
Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro.Q39002702
Nuclear receptor 4A (NR4A) family - orphans no moreQ39013661
A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastomaQ39095788
DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.Q39188747
Tissue-Specific Diversity and Functions of Conventional Dendritic Cells.Q39245056
Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL.Q39716580
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)1797
P577publication date2018-01-01
P1433published inFrontiers in ImmunologyQ27723748
P1476titleNuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
P478volume9