Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells

scientific article

Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2014.09.027
P932PMC publication ID4312239
P698PubMed publication ID25284689
P5875ResearchGate publication ID267028758

P50authorJianxin SunQ42616615
P2093author name stringPing Yang
Ming Chen
Bing Yi
Qing Qin
Xiaohua You
P2860cites workEndothelin and endothelin receptors in the renal and cardiovascular systemsQ26862460
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3Q28246420
Vascular endothelin receptor type B: structure, function and dysregulation in vascular diseaseQ28263963
Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanismQ28568359
Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expressionQ28570520
AP-1 as a regulator of cell life and deathQ29616558
Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugsQ31531733
Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoterQ31814866
Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1Q33577496
Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.Q33940517
Endothelial dysfunction and atherosclerosis: endothelin receptor antagonists as novel therapeuticsQ34028426
c-Jun and the transcriptional control of neuronal apoptosisQ34047159
High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cellsQ34131715
Endothelin-1 gene regulationQ34421747
Targeting Nur77 translocationQ34588195
The endothelin system in pulmonary arterial hypertensionQ35635106
The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.Q36017199
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activityQ36228417
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activationQ36703723
Mechanisms of ET-1-induced endothelial dysfunctionQ37037144
Endothelin--role in vascular diseaseQ37265810
Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sitesQ37433354
NR4All in the vessel wallQ37833366
c-Jun, at the crossroad of the signaling networkQ37969687
Endothelin receptor antagonists for the treatment of pulmonary artery hypertensionQ38033905
Cytosporone B is an agonist for nuclear orphan receptor Nur77.Q39952461
6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formationQ40200614
Circulating and tissue endothelin immunoreactivity in advanced atherosclerosisQ41160044
Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathwayQ42477113
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosisQ42573987
Regulation of endothelin-1 gene expression by Fos and Jun.Q44491830
Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cellsQ46853309
Vascular gene expression in mice overexpressing human endothelin-1 targeted to the endothelium.Q50556171
Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes.Q50767621
The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.Q51824215
Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation.Q53575755
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.Q54212669
Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances AtherosclerosisQ63917005
The role of c-Jun protein in thrombin-stimulated expression of preproendothelin-1 mRNA in porcine aortic endothelial cellsQ72870655
Thrombin induces endothelin expression in arterial smooth muscle cellsQ73698519
Dexamethasone inhibits stimulation of pulmonary endothelins by proinflammatory cytokines: possible involvement of a nuclear factor kappa B dependent mechanismQ73997319
6-Mercaptopurine reverses experimental vasospasm and alleviates the production of endothelins in NO-independent mechanism-a laboratory studyQ82954015
Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levelsQ83067693
P921main subjectendotheliumQ111140
P304page(s)20-28
P577publication date2014-10-02
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleOrphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells
P478volume77

Reverse relations

cites work (P2860)
Q41900644Berberine protects vascular endothelial cells in hypertensive rats
Q52338555Mechanotransduction in Coronary Vein Graft Disease.
Q58801877Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
Q38378655Nuclear receptors in vascular biology.
Q37549431Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model
Q51312490Nur77 downregulation triggers pulmonary artery smooth muscle cell proliferation and migration in mice with hypoxic pulmonary hypertension via the Axin2-β-catenin signaling pathway.
Q36033395Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation
Q64121507The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review
Q90101156Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes

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