Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

scientific article published on 2 February 2016

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1001572135
P356DOI10.1186/S12950-016-0112-9
P932PMC publication ID4735956
P698PubMed publication ID26839514
P5875ResearchGate publication ID292672692

P2093author name stringHua Wu
Jian-Ming Li
Xiao-Shun He
Shen Zhang
Jing-Ru Wang
Xiu-Ming Li
Peng-Da Guo
Xing-Xing Lu
P2860cites workAssociation of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signalingQ24299892
Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cellsQ24644489
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammationQ27700060
Mechanisms underlying ubiquitinationQ27860656
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Proteasome-independent functions of ubiquitin in endocytosis and signalingQ28282959
HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitinationQ28298562
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.Q34474472
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responsesQ34551946
Targeting Nur77 translocationQ34588195
Identification of the DNA binding site for NGFI-B by genetic selection in yeastQ34955524
Nur77 deficiency leads to systemic inflammation in elderly miceQ35781978
Sepsis: definition, epidemiology, and diagnosisQ36095399
Dissecting negative regulation of Toll-like receptor signalingQ38020637
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal OncogenesisQ38811663
ISG12 is a critical modulator of innate immune responses in murine models of sepsisQ39142548
NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axisQ40325258
Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage.Q40473289
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosisQ42573987
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.Q50764082
Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin.Q51066152
Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic miceQ64378477
Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite releaseQ72412472
Effect of age and carbon tetrachloride on cytokine concentrations in rat liverQ77984349
P921main subjectsepsisQ183134
P304page(s)4
P577publication date2016-02-02
P1433published inJournal of InflammationQ15757699
P1476titleNur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
P478volume13

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cites work (P2860)
Q41204170Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance
Q58614136MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice
Q58801877Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
Q36272861Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression
Q64904496Nur77 promotes cigarette smoke‑induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1.
Q41883058Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20.
Q52661592TRAF molecules in inflammation and inflammatory diseases.
Q39068323The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases

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