Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation

scientific article published on 26 September 2012

Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.201242523
P698PubMed publication ID22890791

P50authorDaniel F LeglerQ54858768
P2093author name stringEva Singer
Markus Bruckner
Denise Dickel
P2860cites workAntigen presentation and T cell stimulation by dendritic cellsQ22255632
Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory StimuliQ63363442
Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsQ74179201
Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skinQ77995830
CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2Q24298801
CCR7 and its ligands: balancing immunity and toleranceQ24316090
Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cellsQ24317518
Reciprocal regulation of inflammation and lipid metabolism by liver X receptorsQ28202771
Prostaglandins and leukotrienes: advances in eicosanoid biologyQ28208246
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organsQ28217626
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansionQ28509130
Rapid leukocyte migration by integrin-independent flowing and squeezingQ29620345
Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptorsQ33230925
Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.Q33507471
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infectionQ33628817
In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cellsQ33714400
PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cellsQ34124931
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cellsQ34141893
LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regressionQ34360087
9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and pQ34579180
Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migrationQ34768912
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gutQ34790350
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.Q35553327
PGE2-induced metalloproteinase-9 is essential for dendritic cell migrationQ36384618
Dendritic cells in a mature age.Q36475977
Fascin1 promotes cell migration of mature dendritic cells.Q36479671
Integration of metabolism and inflammation by lipid-activated nuclear receptorsQ37225357
Mechanisms and consequences of dendritic cell migrationQ37272221
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosisQ37463199
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responsesQ39758426
CCR7-specific migration to CCL19 and CCL21 is induced by PGE(2) stimulation in human monocytes: Involvement of EP(2)/EP(4) receptors activationQ39834801
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signalingQ41330743
Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells.Q44436559
Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cellsQ44576443
A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2.Q45119186
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.Q46034364
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7.Q47915773
Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.Q53574931
Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDOQ57896753
P433issue11
P921main subjectcell migrationQ189092
dendritic cellQ506253
P304page(s)2949-2958
P577publication date2012-09-26
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleConverse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation
P478volume42

Reverse relations

cites work (P2860)
Q41818188CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2.
Q47099855Cox-2 inhibition and the composition of inflammatory cell populations during early and mid-time tendon healing
Q92142218E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions
Q40548665Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells.
Q52728752LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis.
Q26824274LXR-dependent and -independent effects of oxysterols on immunity and tumor growth
Q26769924MGL Receptor and Immunity: When the Ligand Can Make the Difference
Q64996233Microenvironmental derived factors modulating dendritic cell function and vaccine efficacy: the effect of prostanoid receptor and nuclear receptor ligands.
Q54968645NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis.
Q58801877Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function
Q37452166The transcription factor NR4A3 controls CD103+ dendritic cell migration

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