SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration

scientific article published on 22 January 2015

SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1053/J.GASTRO.2015.01.027
P932PMC publication ID4375031
P698PubMed publication ID25620669
P5875ResearchGate publication ID271535395

P50authorHeba NowyhedQ62033388
Klaus F. LeyQ89016809
P2093author name stringFabio Cominelli
Theresa T Pizarro
Grzegorz Chodaczek
Gisen Kim
Zbigniew Mikulski
Rebecca Johnson
Iftach Shaked
Wendy Goodman
P2860cites workCCR7 and its ligands: balancing immunity and toleranceQ24316090
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homingQ24646057
Crohn's diseaseQ28273481
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogensQ28509751
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cellsQ28591976
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineagesQ28594572
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
Retinoic acid imprints gut-homing specificity on T cellsQ29619126
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's diseaseQ30307038
Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in miceQ30308331
Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitisQ30310728
Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFcQ30311093
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitisQ30423660
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritisQ30434426
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammationQ30436253
The primary defect in experimental ileitis originates from a nonhematopoietic sourceQ30439653
Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic miceQ34110300
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulationQ34580976
DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawlingQ35237489
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.Q35577590
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouseQ35822641
Oral tolerance and inflammatory bowel diseaseQ36284143
Extrathymically generated regulatory T cells control mucosal TH2 inflammationQ36359813
Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's diseaseQ36711547
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responsesQ36882237
Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitisQ37053099
CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease.Q37073770
Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism.Q37194987
Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammationQ37240497
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's diseaseQ37331540
Role of the lymphatic system in the pathogenesis of Crohn's diseaseQ37872180
Intestinal CD103+ dendritic cells: master regulators of tolerance?Q37911701
Induced CD4+Foxp3+ regulatory T cells in immune toleranceQ37973769
Lymph node homing of T cells and dendritic cells via afferent lymphaticsQ37998206
GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacityQ41870391
Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanismQ41932564
Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitisQ42024414
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.Q42138485
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cellsQ42766901
Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells.Q43975582
The forgotten role of lymphangitis in Crohn's diseaseQ44766457
Interstitial dendritic cell guidance by haptotactic chemokine gradientsQ44994477
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.Q51002504
Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune ResponsesQ57227496
Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infectionsQ81392130
CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodesQ82176277
CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19Q83123386
Regulation of intestinal dendritic cell migration and activation by plasmacytoid dendritic cells, TNF-alpha and type 1 IFNs after feeding a TLR7/8 ligandQ83170009
Oral toleranceQ83849376
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
ileitisQ3796380
P304page(s)783-793.e5
P577publication date2015-01-22
P1433published inGastroenterologyQ4039279
P1476titleSAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration
P478volume148

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cites work (P2860)
Q64268916IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
Q39286346Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
Q26774688Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection
Q96304847Sex-based differences in inflammatory bowel diseases: a review
Q33711741Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model?