BK Channels in the Central Nervous System.

scientific article

BK Channels in the Central Nervous System. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/BS.IRN.2016.04.001
P932PMC publication ID4902275
P698PubMed publication ID27238267

P2093author name stringA L Barth
C Contet
D A Kuljis
S P Goulding
P2860cites workMolecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homologQ22009115
Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2Q22010884
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4Q22253242
Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channelQ22253909
A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxinQ22254019
Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brainQ24310769
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channelQ24311958
Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosisQ24319132
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiencyQ24563081
Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanismQ24594703
Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcoholQ24646484
Genome-wide atlas of gene expression in the adult mouse brainQ26253934
Signal processing by T-type calcium channel interactions in the cerebellumQ26850970
Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memoryQ27301314
Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizuresQ28115339
Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutationQ34770161
Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neuronsQ34785622
The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channelsQ34830961
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sampleQ34872842
Unconventional myristoylation of large-conductance Ca²⁺-activated K⁺ channel (Slo1) via serine/threonine residues regulates channel surface expressionQ35081489
Fast delayed rectifier potassium current: critical for input and output of the circadian systemQ35132252
Increased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid LipofuscinosisQ35532437
Local calcium signaling in neurons.Q35558435
BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje CellsQ35572521
The LRRC26 protein selectively alters the efficacy of BK channel activatorsQ35647406
Impaired clock output by altered connectivity in the circadian network.Q35720686
Purkinje cell dysfunction and alteration of long-term synaptic plasticity in fetal alcohol syndromeQ35834342
An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca2+-activated K+ channel splice variantQ35971079
Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in DrosophilaQ35995334
Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neuronsQ36019756
Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!Q36062613
Fluorogenic Green-Inside Red-Outside (GIRO) Labeling Approach Reveals Adenylyl Cyclase-Dependent Control of BKα Surface ExpressionQ36076644
GDNF induces mechanical hyperalgesia in muscle by reducing I(BK) in isolectin B4-positive nociceptorsQ36114586
The retinal pigment epithelium in visual functionQ36178984
Aging human circadian rhythms: conventional wisdom may not always be rightQ36217289
Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunitQ36298212
Calcium-activated potassium channels and the regulation of vascular toneQ36380601
Calcium channels that are required for secretion from intact nerve terminals of vertebrates are sensitive to omega-conotoxin and relatively insensitive to dihydropyridines. Optical studies with and without voltage-sensitive dyesQ36410247
Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.Q36414675
Ionic channels of the inner segment of tiger salamander cone photoreceptorsQ36434444
BK Channel β1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure.Q36460119
MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brainQ36535168
Inhibition of martentoxin on neuronal BK channel subtype (alpha+beta4): implications for a novel interaction modelQ36538252
Mechanism of generation of spontaneous miniature outward currents (SMOCs) in retinal amacrine cellsQ36558167
Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behaviorQ36593216
A role for synaptic plasticity in the adolescent development of executive functionQ36764491
Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivationQ36798429
Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variantsQ36812505
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somataQ36840942
Diversity and dynamics of dendritic signalingQ28142303
A central role of the BK potassium channel in behavioral responses to ethanol in C. elegansQ28191512
BMS-204352: a potassium channel opener developed for the treatment of strokeQ28217424
Coordinated transcription of key pathways in the mouse by the circadian clockQ28217978
Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brainQ28290233
Human and rodent MaxiK channel beta-subunit genes: cloning and characterizationQ28293893
Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and functionQ28475707
Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neuronsQ28504603
Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexesQ28508367
BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker outputQ28508404
A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochleaQ28509094
Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channelsQ28511091
A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channelsQ28511241
Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channelQ28564374
MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial locationQ28565445
Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channelQ28566676
The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constrictionQ28570038
Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brainQ28572874
Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter releaseQ28573459
BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signalingQ28577412
Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochleaQ28580648
A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunitsQ28589111
I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activityQ28593648
Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous systemQ28754371
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and functionQ29547320
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.Q30362741
Alcohol withdrawal is associated with a downregulation of large-conductance Ca²⁺-activated K⁺ channels in rat inferior colliculus neuronsQ30413260
Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegansQ30420695
Replication study of genome-wide associated SNPs with late-onset Alzheimer's diseaseQ30426556
Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.Q30474373
BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retinaQ30485717
Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.Q30493752
Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsyQ30497593
Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expressionQ36882928
Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal NeuronsQ36917425
The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.Q36937218
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcoholQ36970958
Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.Q37000100
Palmitoylation gates phosphorylation-dependent regulation of BK potassium channelsQ37020705
Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neuronsQ37020829
Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia modelQ37113718
Mechanism of increased BK channel activation from a channel mutation that causes epilepsy.Q37124257
The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinearQ37135618
A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neuronsQ37150710
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer diseaseQ37156208
Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channelsQ37192968
Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's diseaseQ37236385
Regulation of synaptic transmission by presynaptic CaMKII and BK channelsQ37251548
Control of K(Ca) channels by calcium nano/microdomainsQ37279412
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependenceQ37369050
Use of toxins to study potassium channelsQ37380269
Magnesium homeostasis and alcohol consumptionQ37409404
BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice.Q37417873
Conopeptide Vt3.1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions.Q37596310
Predicting the diagnosis of autism spectrum disorder using gene pathway analysisQ37663731
The effect of paxilline on early alterations of electrophysiological properties of dentate gyrus granule cells in pilocarpine-treated ratsQ37687186
slo K(+) channel gene regulation mediates rapid drug toleranceQ37704766
Hypothalamic tanycytes: potential roles in the control of feeding and energy balanceQ38075285
The translation of translational control by FMRP: therapeutic targets for FXS.Q38098906
The suprachiasmatic nucleus and the circadian timing systemQ38125283
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cellsQ38179410
Current understanding of iberiotoxin-resistant BK channels in the nervous systemQ38262896
KCNMB1 regulates surface expression of a voltage and Ca2+-activated K+ channel via endocytic trafficking signals.Q38310655
Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons.Q38341387
Mono- and dual-frequency fast cerebellar oscillation in mice lacking parvalbumin and/or calbindin D-28k.Q38486929
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channelsQ38525116
Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytesQ48678447
Ethanol tolerance caused by slowpoke induction in DrosophilaQ48705614
BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.Q48711238
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesiaQ48726839
Repolarizing responses of BKCa-Cav complexes are distinctly shaped by their Cav subunits.Q48741212
Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neuronsQ48792331
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.Q48933018
Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a.Q48965555
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminalsQ49158543
Localization and developmental expression of BK channels in mammalian cochlear hair cells.Q50475244
CaV1.3 L-type channels, maxiK Ca(2+)-dependent K(+) channels and bestrophin-1 regulate rhythmic photoreceptor outer segment phagocytosis by retinal pigment epithelial cells.Q50481190
Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome.Q50561718
De novo KCNMA1 mutations in children with early-onset paroxysmal dyskinesia and developmental delay.Q50576882
Daily rhythmicity of large-conductance Ca2+ -activated K+ currents in suprachiasmatic nucleus neurons.Q50742988
A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons.Q51550169
Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions.Q51631814
Molecular and electrophysiological evidence for the expression of BK channels in oligodendroglial precursor cells.Q51860103
Ca(2+)-BK channel clusters in olfactory receptor neurons and their role in odour coding.Q52148190
Properties and functions of calcium-activated K+ channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation.Q52234056
Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium-channel-blocking drugs and mutationsQ52441402
BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina.Q53174833
Differential distribution of Ca2+-activated potassium channel beta4 subunit in rat brain: immunolocalization in neuronal mitochondria.Q53427640
Ca2+ -activated K+ current at presynaptic terminals of goldfish retinal bipolar cells.Q53602603
Characterization of maxi-K-channels in bovine trabecular meshwork and their activation by cyclic guanosine monophosphate.Q53965711
A family of calcium-dependent potassium channels from rat brain.Q54116987
Electrical resonance and Ca2+ influx in the synaptic terminal of depolarizing bipolar cells from the goldfish retina.Q54147994
BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.Q54447158
Expression and functional role of BK channels in chronically injured spinal cord white matterQ57839258
Vertebrate rod photoreceptors express both BK and IK calcium-activated potassium channels, but only BK channels are involved in receptor potential regulationQ62030311
Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channelsQ67530880
Cysteine string protein limits expression of the large conductance, calcium-activated K⁺ (BK) channelQ39029381
Palmitoylation of the S0-S1 Linker Regulates Cell Surface Expression of Voltage- and Calcium-activated Potassium (BK) ChannelsQ39669874
BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons.Q39707555
Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligenceQ39743829
BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neuronsQ39746166
Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cellsQ39903485
Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expressionQ40035666
A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membraneQ40054967
The beta 1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channelsQ40054974
Beta1-subunits increase surface expression of a large-conductance Ca2+-activated K+ channel isoformQ40165240
Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain.Q40168903
Cellular and molecular effects of unoprostone as a BK channel activator.Q40169962
A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons.Q40346431
Charybdotoxin and its effects on potassium channelsQ40403043
Testing the level of response to alcohol: social information processing model of alcoholism risk--a 20-year prospective study.Q40460005
Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens.Q40532711
Unoprostone activation of BK (KCa1.1) channel splice variantsQ40639347
A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channelsQ40811888
High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit compositionQ40958112
Age-related changes in large-conductance calcium-activated potassium channels in mammalian circadian clock neuronsQ41310689
Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels.Q41335081
Intracellular injection of a Ca2+ chelator inhibits spike repolarization in hippocampal neuronsQ41386884
Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.Q41486765
A-272651, a nonpeptidic blocker of large-conductance Ca2+-activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentialsQ41590912
The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosisQ41592605
Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channelQ41602832
Microglial K(+) channel expression in young adult and aged mice.Q41620046
Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter releaseQ41737185
Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons.Q41883103
Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different agesQ42001043
Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neuronsQ42223924
Activation of large-conductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 miceQ42437307
Molecular studies of BKCa channels in intracranial arteries: presence and localizationQ42443849
BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampusQ42458933
Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradientsQ42465201
Ca2+ -activated K+ channels of the BK-type in the mouse brainQ42488168
Sparse but highly efficient Kv3 outpace BKCa channels in action potential repolarization at hippocampal mossy fiber boutons.Q42489317
BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells.Q42508404
Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeetQ42528081
cAMP-dependent signaling as a core component of the mammalian circadian pacemakerQ42541521
The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string proteinQ42555501
Beta-subunits are important modulators of the acute response to alcohol in human BK channelsQ42615817
Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorderQ42658736
Ca2+-dependent inactivation of large conductance Ca2+-activated K+ (BK) channels in rat hippocampal neurones produced by pore block from an associated particleQ42674621
LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cellsQ42764604
Bmal1 is an essential regulator for circadian cytosolic Ca²⁺ rhythms in suprachiasmatic nucleus neurons.Q42796076
Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminalsQ42948092
Calcium-induced transitions between the spontaneous miniature outward and the transient outward currents in retinal amacrine cellsQ43135829
Ethanol Effect on BK Channels is Modulated by MagnesiumQ43217494
Iberiotoxin-sensitive large conductance Ca2+ -dependent K+ (BK) channels regulate the spike configuration in the burst firing of cerebellar Purkinje neuronsQ43553116
Ethanol reduces excitability in a subgroup of primary sensory neurons by activation of BK(Ca) channelsQ43795831
Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents.Q43809591
Mechanisms of action of unoprostone on trabecular meshwork contractility.Q43811171
Physiological role of calcium-activated potassium currents in the rat lateral amygdala.Q43906972
Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neuronsQ43945364
Trichloroethanol alters action potentials in a subgroup of primary sensory neuronesQ43984685
BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice culturesQ44014257
Dendritic spikes as a mechanism for cooperative long-term potentiation.Q44068803
Abnormal spontaneous and harmaline-stimulated Purkinje cell activity in the awake genetically dystonic rat.Q44097935
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membraneQ44201844
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in miceQ44280694
Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron functionQ44308519
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells.Q44317045
Peripheral μ-opioid receptor mediated inhibition of calcium signaling and action potential-evoked calcium fluorescent transients in primary afferent CGRP nociceptive terminals.Q44349916
Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.Q44357310
Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic nucleus neurons.Q44420137
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.Q44422639
Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons.Q44433370
K+ channels in cultured bovine retinal pericytes: effects of beta-adrenergic stimulationQ44576727
Ca2+-activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdalaQ44619545
Long-lasting increases in intrinsic excitability triggered by inhibitionQ44671467
Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neuronsQ44672754
Chemokine modulation of high-conductance Ca(2+)-sensitive K(+) currents in microglia from human hippocampiQ44680416
Properties of two calcium-activated hyperpolarizations in rat hippocampal neuronesQ44788685
Rhythmic regulation of membrane potential and potassium current persists in SCN neurons in the absence of environmental inputQ45014698
Single-shock LTD by local dendritic spikes in pyramidal neurons of mouse visual cortexQ45023556
Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density.Q45072863
Modulation of aqueous humor outflow by ionic mechanisms involved in trabecular meshwork cell volume regulation.Q45081351
Fast cerebellar oscillation associated with ataxia in a mouse model of Angelman syndrome.Q45181869
Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice culturesQ45243974
The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in miceQ45266148
Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.Q45939384
Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains.Q46026913
Maturation of spiking activity in trout retinal ganglion cells coincides with upregulation of Kv3.1- and BK-related potassium channelsQ34285520
Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleusQ34303241
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.Q34314406
Low level of response to alcohol as a predictor of future alcoholismQ34348860
Large conductance voltage- and Ca2+-gated potassium (BK) channel β4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinasesQ34355783
Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junctionQ34416465
Interactions between adenosine and K+channel-related pathways in the coupling of somatosensory activation and pial arteriolar dilationQ34426227
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener moleculeQ34431654
Action potential refractory period in ureter smooth muscle is set by Ca sparks and BK channelsQ34437712
Functional upregulation of Ca(2+)-activated K(+) channels in the development of substantia nigra dopamine neuronsQ34532038
N-methyl-D-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce mu-opioid receptor internalization in the rat spinal cordQ34536694
Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardationQ34562461
Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsyQ34564233
Western blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodiesQ34622924
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexesQ34692423
Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminalsQ70920199
Calcium-activated potassium current in cultured rabbit retinal pigment epithelial cellsQ71129688
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channelsQ71623113
Inactivation of a high conductance calcium dependent potassium current in rat hippocampal neuronsQ71760608
Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter releaseQ72096278
The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cellsQ73184395
Contribution of presynaptic calcium-activated potassium currents to transmitter release regulation in cultured Xenopus nerve-muscle synapsesQ73559478
Relationship between large conductance calcium-activated potassium channel and bursting activityQ73571701
Inferior colliculus intracellular response abnormalities in vitro associated with susceptibility to ethanol withdrawal seizuresQ74253070
BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cellsQ77734794
Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neuronsQ77906734
Pharmacological evidence for the participation of NO-cyclic GMP-PKG-K+ channel pathway in the antiallodynic action of resveratrolQ80087320
BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivoQ83145663
Knock-down of synapsin alters cell excitability and action potential waveform by potentiating BK and voltage-gated Ca(2+) currents in Helix serotonergic neuronsQ86600232
Large conductance calcium-activated potassium channels: their expression and modulation of glutamate release from nerve terminals isolated from rat trigeminal caudal nucleus and cerebral cortexQ87517640
The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiationQ46117202
Genetic suppression of seizure susceptibility in DrosophilaQ46160513
Anticonvulsant effects of the BK-channel antagonist paxillineQ46215516
Development of BK channels in neocortical pyramidal neuronsQ46300475
Large-conductance calcium-dependent potassium channels prevent dendritic excitability in neocortical pyramidal neuronsQ46397434
Vasoregulation by the beta1 subunit of the calcium-activated potassium channelQ46410172
Presynaptic large-conductance calcium-activated potassium channels control synaptic transmission in the superficial dorsal horn of the mouseQ46425949
Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock.Q46606141
Distribution and regulation of L-type calcium channels in deep dorsal horn neurons after sciatic nerve injury in ratsQ46606167
Large-conductance calcium-activated potassium channels facilitate transmitter release in salamander rod synapse.Q46656546
Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channelsQ46706011
The slowpoke gene is necessary for rapid ethanol tolerance in DrosophilaQ46790621
Differential expression of BK channel isoforms and beta-subunits in rat neuro-vascular tissuesQ46819371
Autosomal linkage analysis for the level of response to alcoholQ46844753
Calcium-activated potassium conductances in retinal ganglion cells of the ferretQ46848800
Ion channel expression in resting and activated microglia of hippocampal slices from juvenile miceQ46898337
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control studyQ46969020
Coassembly of big conductance Ca2+-activated K+ channels and L-type voltage-gated Ca2+ channels in rat brainQ47310467
Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellumQ47750692
Expression of a potassium current in inner hair cells during development of hearing in miceQ47908346
Control of alternative splicing of potassium channels by stress hormones.Q48038386
Differential expression of the alpha and beta subunits of the large-conductance calcium-activated potassium channel: implication for channel diversityQ48051992
Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons.Q48093992
Inactivation of calcium-binding protein genes induces 160 Hz oscillations in the cerebellar cortex of alert mice.Q48094253
Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model miceQ48140389
Effects of various K+ channel blockers on spontaneous glycine release at rat spinal neuronsQ48143681
Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endingsQ48146605
Ionic Mechanisms of Burst Firing in Dissociated Purkinje NeuronsQ48164908
Circadian waves of cytosolic calcium concentration and long-range network connections in rat suprachiasmatic nucleusQ48170315
Phase-resetting curve determines how BK currents affect neuronal firingQ48178797
Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic painQ48208669
Brain mitochondrial ATP-insensitive large conductance Ca⁺²-activated K⁺ channel properties are altered in a rat model of amyloid-β neurotoxicity.Q48252848
A calcium-activated potassium channel causes frequency-dependent action-potential failures in a mammalian nerve terminalQ48253270
The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channelsQ48258236
MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulinQ48273824
Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons.Q48305718
Chlorpromazine confers neuroprotection against brain ischemia by activating BKCa channelQ48308833
Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses.Q48310664
Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus.Q48325897
Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neuronsQ48357057
Compartmentalized Ca(2+) channel regulation at divergent mossy-fiber release sites underlies target cell-dependent plasticityQ48377511
Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's diseaseQ48380259
Three potassium channels in rat posterior pituitary nerve terminalsQ48403889
Local potassium signaling couples neuronal activity to vasodilation in the brain.Q48407816
Immunolocalization of BK channels in hippocampal pyramidal neuronsQ48449227
Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neuronsQ48457851
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice.Q48460762
Mechanism of increased open probability by a mutation of the BK channel.Q48515509
Dendritic calcium spikes are tunable triggers of cannabinoid release and short-term synaptic plasticity in cerebellar Purkinje neuronsQ48535117
Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels.Q30498186
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleusQ30501017
Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels.Q30514232
FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channelsQ30536899
Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channelsQ30644520
BK potassium channel modulation by leucine-rich repeat-containing proteinsQ31814786
Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNSQ33252022
Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neuronsQ33318188
Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsyQ33320921
BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivoQ33517128
Quantitative localization of Cav2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels.Q33652631
Neuronal Ca2+-activated K+ channels limit brain infarction and promote survivalQ33786915
Role of glial K(+) channels in ontogeny and gliosis: a hypothesis based upon studies on Müller cellsQ33792534
An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel.Q33834949
Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cellsQ33865667
Back-Propagation of Physiological Action Potential Output in Dendrites of Slender-Tufted L5A Pyramidal NeuronsQ33878210
Cysteine-string protein: the chaperone at the synapseQ33901003
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit familyQ33903332
Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Q33907650
Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channelsQ33982019
Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic painQ34002411
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensingQ34010440
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythmsQ34058703
Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neuronsQ34073523
CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylationQ34077155
Conserved BK channel-protein interactions reveal signals relevant to cell death and survivalQ34103180
Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other familiesQ34123856
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementiasQ34133701
BK channels play a counter-adaptive role in drug tolerance and dependenceQ34136282
The brain-specific Beta4 subunit downregulates BK channel cell surface expressionQ34206237
The endoplasmic reticulum: one continuous or several separate Ca(2+) stores?Q34224635
Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.Q34262501
Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivationQ34276135
P407language of work or nameEnglishQ1860
P304page(s)281-342
P577publication date2016-05-13
P1433published inInternational Review of NeurobiologyQ15754273
P1476titleBK Channels in the Central Nervous System.
P478volume128

Reverse relations

cites work (P2860)
Q55441235A BK channel–mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing.
Q52708927A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons.
Q37329741Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling
Q54090250Calcium-activated potassium channels as potential early markers of human cervical cancer.
Q92084538Comparative gain-of-function effects of the KCNMA1-N999S mutation on human BK channel properties
Q64054395Dual separable feedback systems govern firing rate homeostasis
Q64118781Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus
Q52373030Hypothalamic Ion Channels in Hypertension.
Q97522071Intellectual Disability and Potassium Channelopathies: A Systematic Review
Q90265798Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability
Q47269323Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies
Q92708313KCNMA1-linked channelopathy
Q90063172Neurexins cluster Ca2+ channels within the presynaptic active zone
Q58572109Overexpression of in Dorsal CA1 of Offspring Mice Rescues Hippocampal Dysfunction Caused by a Methyl Donor-Rich Paternal Diet
Q92826572Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain
Q57446278Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington’s disease
Q38747482Polysialic Acid Regulates Sympathetic Outflow by Facilitating Information Transfer within the Nucleus of the Solitary Tract.
Q57752463RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated Ca-channels
Q49874167Serotonin disinhibits a Caenorhabditis elegans sensory neuron by suppressing Ca++-dependent negative feedback.
Q45911718Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum.
Q89724523Targeting BKCa Channels in Migraine: Rationale and Perspectives
Q92816765The Biosynthesis, Signaling, and Neurological Functions of Bile Acids
Q91796761The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review
Q91395091The enantiomer pair of 24S- and 24R-hydroxycholesterol differentially alter activity of large-conductance Ca2+ -dependent K+ (slo1 BK) channel
Q45074747Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons

Search more.